دورية أكاديمية
Neurosteroids and the mesocorticolimbic system.
| العنوان: | Neurosteroids and the mesocorticolimbic system. |
|---|---|
| المؤلفون: | Seib DR; Department of Psychology and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. Electronic address: dseib@upei.ca., Tobiansky DJ; Department of Biology and Neuroscience Program, St. Mary's College of Maryland, St. Mary's City, MD, USA., Meitzen J; Department of Biological Sciences and Center for Human Health and the Environment, NC State University, Raleigh, NC, USA., Floresco SB; Department of Psychology and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Soma KK; Department of Psychology and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. |
| المصدر: | Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2023 Oct; Vol. 153, pp. 105356. Date of Electronic Publication: 2023 Aug 10. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: United States NLM ID: 7806090 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7528 (Electronic) Linking ISSN: 01497634 NLM ISO Abbreviation: Neurosci Biobehav Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Pergamon Press Original Publication: Fayetteville, N. Y., ANKHO International Inc. |
| مستخلص: | The mesocorticolimbic system coordinates executive functions, such as working memory and behavioral flexibility. This circuit includes dopaminergic projections from the ventral tegmental area to the nucleus accumbens and medial prefrontal cortex. In this review, we summarize evidence that cells in multiple nodes of the mesocorticolimbic system produce neurosteroids (steroids synthesized in the nervous system) and express steroid receptors. Here, we focus on neuroandrogens (androgens synthesized in the nervous system), neuroestrogens (estrogens synthesized in the nervous system), and androgen and estrogen receptors. We also summarize how (neuro)androgens and (neuro)estrogens affect dopamine signaling in the mesocorticolimbic system and regulate executive functions. Taken together, the data suggest that steroids produced in the gonads and locally in the brain modulate higher-order cognition and executive functions. Competing Interests: Declarations of interest None (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: 17β-estradiol; Androgen receptor; Aromatase; Brain; Set shifting; Testosterone |
| تواريخ الأحداث: | Date Created: 20230811 Latest Revision: 20231008 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.neubiorev.2023.105356 |
| PMID: | 37567491 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-7528 |
|---|---|
| DOI: | 10.1016/j.neubiorev.2023.105356 |