دورية أكاديمية
أعرض في EDS

Resveratrol-Loaded Attalea funifera Oil Organogel Nanoparticles: A Potential Nanocarrier against A375 Human Melanoma Cells.

التفاصيل البيبلوغرافية
العنوان: Resveratrol-Loaded Attalea funifera Oil Organogel Nanoparticles: A Potential Nanocarrier against A375 Human Melanoma Cells.
المؤلفون: Dourado D; School of Pharmacy, Federal University of Rio Grande do Norte (UFRN), General Gustavo Cordeiro de Faria Street, Natal 59012-570, RN, Brazil.; Department of Immunology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife 50670-420, PE, Brazil., Batista FPR; School of Pharmacy, Federal University of Bahia, Barão de Jeremoabo Street, Salvador 40170-115, BA, Brazil., Philadelpho BO; School of Pharmacy, Federal University of Bahia, Barão de Jeremoabo Street, Salvador 40170-115, BA, Brazil., de Souza ML; College of Pharmacy, Federal University of Pernambuco, Professor Artur de Sá Street, Recife 50740-521, PE, Brazil., de Cerqueira E Silva MB; School of Pharmacy, Federal University of Amazonas, General Rodrigo Octávio Jordão Ramos Avenue, Manaus 69067-005, AM, Brazil., de Grandis RA; School of Pharmacy, São Paulo State University (UNESP), Araraquara-Jaú Road, Araraquara 148000-903, SP, Brazil., Miranda PA; School of Pharmacy, Federal University of Bahia, Barão de Jeremoabo Street, Salvador 40170-115, BA, Brazil., Colauto NB; School of Pharmacy, Federal University of Bahia, Barão de Jeremoabo Street, Salvador 40170-115, BA, Brazil., Pereira DT; School of Pharmacy, Federal University of Rio Grande do Norte (UFRN), General Gustavo Cordeiro de Faria Street, Natal 59012-570, RN, Brazil., Formiga FR; Department of Immunology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (FIOCRUZ), Recife 50670-420, PE, Brazil., Cilli EM; Institute of Chemistry, São Paulo State University (UNESP), Prof. Francisco Swgni Street, Araraquara 14800-0600, SP, Brazil., Pavan FR; School of Pharmacy, São Paulo State University (UNESP), Araraquara-Jaú Road, Araraquara 148000-903, SP, Brazil., Oliveira de Souza C; School of Pharmacy, Federal University of Bahia, Barão de Jeremoabo Street, Salvador 40170-115, BA, Brazil., Ferreira ES; School of Pharmacy, Federal University of Bahia, Barão de Jeremoabo Street, Salvador 40170-115, BA, Brazil.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Jul 28; Vol. 24 (15). Date of Electronic Publication: 2023 Jul 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Resveratrol*/administration & dosage , Melanoma*/therapy , Nanogels*/administration & dosage , Nanogels*/chemistry , Nanoparticle Drug Delivery System* , Arecaceae*/chemistry , Palm Oil*/chemistry , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/chemistry, Humans ; Cell Line, Tumor ; Seeds/chemistry ; Particle Size
مستخلص: This study aimed to evaluate Attalea funifera seed oil with or without resveratrol entrapped in organogel nanoparticles in vitro against A375 human melanoma tumor cells. Organogel nanoparticles with seed oil (SON) or with resveratrol entrapped in the seed oil (RSON) formed functional organogel nanoparticles that showed a particle size <100 nm, polydispersity index <0.3, negative zeta potential, and maintenance of electrical conductivity. The resveratrol entrapment efficiency in RSON was 99 ± 1%. The seed oil and SON showed no cytotoxicity against human non-tumor cells or tumor cells. Resveratrol at 50 μg/mL was cytotoxic for non-tumor cells, and was cytotoxic for tumor cells at 25 μg/mL. Resveratrol entrapped in RSON showed a decrease in cytotoxicity against non-tumor cells and cytotoxic against tumor cells at 50 μg/mL. Thus, SON is a potential new platform for the delivery of resveratrol with selective cytotoxic activity in the treatment of melanoma.
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معلومات مُعتمدة: FAPESB/JCB nº 0012/2016 Fundação de Amparo à Pesquisa do Estado da Bahia; FAPESP nº 2013/07600-3 and 2014/50926-0 São Paulo Research Foundation; nº 316355/2021-6 and nº 301975/2018-3 National Council for Scientific and Technological Development
فهرسة مساهمة: Keywords: cell viability; gelled lipid nanoparticles; medium-chain fatty acids; piassava seed oil; skin cancer
المشرفين على المادة: Q369O8926L (Resveratrol)
0 (Nanogels)
0 (Nanoparticle Drug Delivery System)
5QUO05548Z (Palm Oil)
0 (Antineoplastic Agents)
تواريخ الأحداث: Date Created: 20230812 Date Completed: 20240207 Latest Revision: 20240207
رمز التحديث: 20240207
مُعرف محوري في PubMed: PMC10419039
DOI: 10.3390/ijms241512112
PMID: 37569487
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms241512112