دورية أكاديمية
أعرض في EDS

Composition and Anti- Helicobacter pylori Properties of Essential Oils Obtained from Selected Mentha Cultivars.

التفاصيل البيبلوغرافية
العنوان: Composition and Anti- Helicobacter pylori Properties of Essential Oils Obtained from Selected Mentha Cultivars.
المؤلفون: Piasecki B; Department of Pharmacognosy with the Medicinal Plant Garden, Medical University of Lublin, 1 Chodźki Str., 20-093 Lublin, Poland., Korona-Głowniak I; Department of Pharmaceutical Microbiology, Medical University of Lublin, 1 Chodźki Str., 20-093 Lublin, Poland., Kiełtyka-Dadasiewicz A; Department of Plant Production Technology and Commodity, University of Life Sciences in Lublin, 20-950 Lublin, Poland., Ludwiczuk A; Department of Pharmacognosy with the Medicinal Plant Garden, Medical University of Lublin, 1 Chodźki Str., 20-093 Lublin, Poland.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2023 Jul 27; Vol. 28 (15). Date of Electronic Publication: 2023 Jul 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Oils, Volatile*/pharmacology , Oils, Volatile*/chemistry , Mentha*/chemistry , Helicobacter pylori* , Helicobacter Infections*, Humans ; Menthol/pharmacology ; Menthol/chemistry ; Mentha piperita/chemistry ; Anti-Bacterial Agents/pharmacology
مستخلص: Helicobacter pylori infections are highly common amongst the global population. Such infections have been shown to be the cause of gastric ulcers and stomach carcinoma and, unfortunately, most cases are asymptomatic. Standard treatment requires antibiotics such as metronidazole or azithromycin to which many strains are now resistant. Mentha species have been used as a natural treatment for gastrointestinal diseases throughout history and essential oils (EOs) derived from these plants show promising results as potential antimicrobial agents. In this study, EOs obtained from the leaves and flowers of five cultivars of Mentha × piperita and M. spicata were examined by GC-MS. The investigated mints are representatives of four chemotypes: the menthol chemotype ( M. × piperita 'Multimentha' and M. × piperita 'Swiss'), the piperitenone oxide chemotype ( M. × piperita 'Almira'), the linalool chemotype ( M. × piperita 'Granada'), and the carvone chemotype ( M. spicata 'Moroccan'). The chemical composition of EOs from mint flowers and leaves was comparable with the exception of the Swiss cultivar. Menthol was the most abundant component in the leaves while menthone was highest in flowers. The H. pylori ATCC 43504 reference strain and 10 other H. pylori clinical strains were examined for their sensitivity to the EOs in addition to their major monoterpenoid components (menthol, menthone, carvone, dihydrocarvone, linalool, 1,8-cineole, and limonene). All tested mint EOs showed inhibitory activity against both the reference H. pylori ATCC 43504 strain (MIC 15.6-31.3 mg/L) and clinical H. pylori strains (MIC 50/90 31.3-250 mg/L/62.5-500 mg/L). Among the reference monoterpenes, menthol (MIC 50/90 7.8/31.3 mg/L) and carvone (MIC 50/90 31.3/62.5 mg/L) had the highest anti- H. pylori activity, which also correlated with a higher activity of EOs containing these compounds ( M. × piperita 'Swiss' and M. spicata 'Moroccan'). A synergistic and additive interaction between the most active EOs/compounds and antibiotics possibly points to a new plant-based anti- H. pylori treatment.
References: Phytother Res. 2007 Apr;21(4):308-23. (PMID: 17199238)
Antimicrob Agents Chemother. 2003 Oct;47(10):3240-6. (PMID: 14506036)
J Enzyme Inhib Med Chem. 2022 Dec;37(1):1610-1619. (PMID: 35642325)
ACS Omega. 2021 Sep 22;6(39):25652-25663. (PMID: 34632221)
Int J Mol Sci. 2020 Oct 05;21(19):. (PMID: 33027980)
Clin Microbiol Infect. 2000 Sep;6(9):509-15. (PMID: 11168187)
Nat Prod Commun. 2016 Jul;11(7):1015-1018. (PMID: 30452185)
Molecules. 2021 Dec 13;26(24):. (PMID: 34946632)
Foodborne Pathog Dis. 2012 Aug;9(8):699-705. (PMID: 22827568)
Oncology. 2017;93 Suppl 1:15-19. (PMID: 29258111)
Am J Med. 1987 Apr 27;82(4A):44-54. (PMID: 3107380)
Antimicrob Agents Chemother. 2005 Jun;49(6):2474-8. (PMID: 15917549)
Open Microbiol J. 2014 Feb 07;8:6-14. (PMID: 24627729)
Appl Environ Microbiol. 2012 Aug;78(15):5361-7. (PMID: 22635999)
Pharmaceutics. 2021 Mar 03;13(3):. (PMID: 33802570)
Int J Antimicrob Agents. 2010 Jan;35(1):30-8. (PMID: 19748233)
In Vivo. 2003 Nov-Dec;17(6):541-4. (PMID: 14758718)
Forsch Komplementmed. 2009 Apr;16(2):79-90. (PMID: 19420953)
Phytother Res. 2019 Oct;33(10):2548-2570. (PMID: 31286590)
Pharmazie. 2005 Jul;60(7):498-502. (PMID: 16076074)
Gut. 2017 Jan;66(1):6-30. (PMID: 27707777)
Helicobacter. 2003 Jun;8(3):207-15. (PMID: 12752733)
Biomed Pharmacother. 2017 Oct;94:292-306. (PMID: 28763752)
J Tradit Chin Med. 2017 Feb;37(1):57-63. (PMID: 29956906)
Helicobacter. 2017 Apr;22(2):. (PMID: 27578489)
Ann Clin Microbiol Antimicrob. 2014 Nov 19;13:54. (PMID: 25406585)
Molecules. 2020 Jan 29;25(3):. (PMID: 32013183)
Phytomedicine. 2015 Jan 15;22(1):173-7. (PMID: 25636887)
Phytother Res. 2005 Nov;19(11):988-91. (PMID: 16317658)
Aliment Pharmacol Ther. 2002 Feb;16(2):167-80. (PMID: 11860399)
Microbios. 2001;106 Suppl 1:31-9. (PMID: 11549238)
Chem Biol Interact. 2014 Apr 5;212:11-9. (PMID: 24480520)
معلومات مُعتمدة: DS28 Medical University of Lublin
فهرسة مساهمة: Keywords: Helicobacter pylori; carvone; menthol; mint chemotypes
المشرفين على المادة: 0 (Oils, Volatile)
9NH5J4V8FN (menthone)
1490-04-6 (Menthol)
75GK9XIA8I (carvone)
D81QY6I88E (linalool)
0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20230812 Date Completed: 20230814 Latest Revision: 20230814
رمز التحديث: 20230814
مُعرف محوري في PubMed: PMC10420633
DOI: 10.3390/molecules28155690
PMID: 37570659
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules28155690