دورية أكاديمية
Diffusion and structural MRI as potential biomarkers in people with Parkinson's disease and cognitive impairment.
| العنوان: | Diffusion and structural MRI as potential biomarkers in people with Parkinson's disease and cognitive impairment. |
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| المؤلفون: | Huang CC; Department of Radiology, MacKay Memorial Hospital, Taipei, Taiwan.; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan., Chen PH; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan.; Department of Neurology, MacKay Memorial Hospital, Taipei, Taiwan.; Graduate Institute of Mechanical and Electrical Engineering, National Taipei University of Technology, Taipei, Taiwan., Tsai CC; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan.; Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan., Chiang HF; Department of Radiology, MacKay Memorial Hospital, Taipei, Taiwan.; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan., Hsieh CC; Department of Radiology, MacKay Memorial Hospital, Taipei, Taiwan.; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan., Chen TL; Department of Radiology, MacKay Memorial Hospital, Taipei, Taiwan., Liao WH; Department of Radiology, MacKay Memorial Hospital, Taipei, Taiwan., Chen YL; Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Department of Diagnostic Radiology, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan., Wang JJ; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan. jwang@mail.cgu.edu.tw.; Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan. jwang@mail.cgu.edu.tw.; Department of Diagnostic Radiology, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan. jwang@mail.cgu.edu.tw.; Institute for Radiological Research, Chang Gung University, Taoyuan, Taiwan. jwang@mail.cgu.edu.tw. |
| المصدر: | European radiology [Eur Radiol] 2024 Jan; Vol. 34 (1), pp. 126-135. Date of Electronic Publication: 2023 Aug 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 9114774 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1084 (Electronic) Linking ISSN: 09387994 NLM ISO Abbreviation: Eur Radiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer International, c1991- |
| مواضيع طبية MeSH: | Parkinson Disease*/complications , Parkinson Disease*/diagnostic imaging , Alzheimer Disease*/complications , Cognitive Dysfunction*/complications , Cognitive Dysfunction*/diagnostic imaging, Humans ; Male ; Female ; Middle Aged ; Aged ; Aged, 80 and over ; Amyloid beta-Peptides ; Retrospective Studies ; Magnetic Resonance Imaging/methods ; Neuropsychological Tests ; Biomarkers |
| مستخلص: | Objective: To explore the neuroimage change in Parkinson's disease (PD) patients with cognitive impairments, this study investigated the correlation between plasma biomarkers and morphological brain changes in patients with normal cognition and mild cognitive impairment. The objective was to identify the potential target deposition regions of the plasma biomarkers and to search for the relevant early neuroimaging biomarkers on the basis of different cognitive domains. Methods: Structural brain MRI and diffusion weighted images were analyzed from 49 eligible PD participants (male/female: 27/22; mean age: 73.4 ± 8.5 years) from a retrospective analysis. Plasma levels of α-synuclein, amyloid beta peptide, and total tau were collected. A comprehensive neuropsychological assessment of the general and specific cognitive domains was performed. Difference between PD patients with normal cognition and impairment was examined. Regression analysis was performed to evaluate the correlation between image-derived index and plasma biomarkers or neuropsychological assessments. Results: Significant correlation was found between plasma Aβ-42 level and fractional anisotropy of the middle occipital, angular, and middle temporal gyri of the left brain, as well as plasma T-tau level and the surface area of the isthmus or the average thickness of the posterior part of right cingulate gyrus. Visuospatial and executive function is positively correlated with axial diffusivity in bilateral cingulate gyri. Conclusion: In nondemented PD patients, the target regions for plasma deposition might be located in the cingulate, middle occipital, angular, and middle temporal gyri. Changes from multiple brain regions can be correlated to the performance of different cognitive domains. Clinical Relevance Statement: Cognitive impairment in Parkinson's disease is primarily linked to biomarkers associated with Alzheimer's disease rather than those related to Parkinson's disease and resembles the frontal variant of Alzheimer's disease, which may guide management strategies for cognitive impairment in Parkinson's disease. Key Points: • Fractional anisotropy, surface area, and thickness in the cingulate, middle occipital, angular, and middle temporal gyri can be significantly correlated with plasma Aβ-42 and T-tau level. • Axial diffusivity in the cingulate gyri was correlated with visuospatial and executive function. • The pattern of cognitive impairment in Parkinson's disease can be similar to the frontal variant than typical Alzheimer's disease. (© 2023. The Author(s), under exclusive licence to European Society of Radiology.) |
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| معلومات مُعتمدة: | MMH-MM-10811 Mackay Medical College; Mackay Memorial Hospital; NTUT-MMH-109-07 National Taipei University of Technology; MOST 109-2221-E-182-009-MY3 Ministry of Science and Technology, Taiwan; MOST 109-2314-B-182-021-MY3 Ministry of Science and Technology, Taiwan; EMRPD1I0501 the Healthy Aging Research Center; EMRPD1I0471 the Healthy Aging Research Center; EMRPD1M0451 the Healthy Aging Research Center; EMRPD1M0431 the Healthy Aging Research Center; CMRPG2J0142 Chang Gung Memorial Hospital; CMRPD1L0141 Chang Gung Memorial Hospital |
| فهرسة مساهمة: | Keywords: Cognition; Cortical volume; Diffusion tensor imaging; Parkinson’s disease; Plasma biomarkers |
| المشرفين على المادة: | 0 (Amyloid beta-Peptides) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20230812 Date Completed: 20240118 Latest Revision: 20240712 |
| رمز التحديث: | 20240712 |
| DOI: | 10.1007/s00330-023-10012-8 |
| PMID: | 37572194 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1432-1084 |
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| DOI: | 10.1007/s00330-023-10012-8 |