دورية أكاديمية
أعرض في EDS

Risk of atrial fibrillation in individuals with dysglycemia and diabetes.

التفاصيل البيبلوغرافية
العنوان: Risk of atrial fibrillation in individuals with dysglycemia and diabetes.
المؤلفون: Rørth R; Steno Diabetes Center Copenhagen, Denmark; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. Electronic address: rasmusroerth@hotmail.com., Kriegbaum M; Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Grand MK; Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Jacobsen PK; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Lind BS; Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Andersen CL; Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Persson F; Steno Diabetes Center Copenhagen, Denmark.
المصدر: Journal of diabetes and its complications [J Diabetes Complications] 2023 Sep; Vol. 37 (9), pp. 108579. Date of Electronic Publication: 2023 Jul 29.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Pub. Co Country of Publication: United States NLM ID: 9204583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-460X (Electronic) Linking ISSN: 10568727 NLM ISO Abbreviation: J Diabetes Complications Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Elsevier Science Pub. Co., c1992-
مواضيع طبية MeSH: Atrial Fibrillation*/complications , Atrial Fibrillation*/epidemiology , Prediabetic State*/complications , Prediabetic State*/epidemiology , Diabetes Mellitus*/epidemiology , Stroke*/epidemiology , Stroke*/etiology , Myocardial Infarction*, Male ; Humans ; Female ; Risk Factors
مستخلص: Objective: Diabetes is a risk factor for atrial fibrillation (AF), and increases the risk of thromboembolic events in persons with AF. However, the link between the two conditions is not fully elucidated. Few studies have investigated the association of dysglycemia and incident AF. We investigated the risk of incident AF and prognosis according to diabetes status.
Research Design and Methods: The Copenhagen Primary Care Laboratory Database was merged with data on medical prescriptions, in- and outpatient contacts and vital status. The risk of AF according to diabetes status was investigated by use of Cox regression models.
Results: Of 354.807 individuals with a hemoglobin A1c (HbA 1c ) measurement, 28.541 (8 %) had known diabetes, 13.038 (4 %) had new onset diabetes and 27.754 (8 %) had prediabetes (HbA 1c 42-47 mmol/mol). Persons with dysglycemia (HbA 1c  > 42 mmol/mol) and diabetes were older, more were men, they had lower level of education and were more likely to be living alone. We observed a gradual increase in risk of developing AF from HbA 1c levels of 40 to 60 mmol/mol. In adjusted analyses we found a stepwise increase in hazard of AF from normoglycemia over prediabetes to persons with diabetes (no diabetes: 1.00 [ref.]; prediabetes: 1.12 [1.08-1.16]; new-onset diabetes: 1.16 [1.10-1.22]; known diabetes: 1.15 [1.11-1.20]). Persons with known diabetes had a significant higher hazard of stroke, cardiovascular and all-cause mortality.
Conclusion: Increasing levels of HbA 1c were associated with an increased hazard of developing AF. Persons with new onset of diabetes and those with known diabetes had similar hazard of developing AF, however persons with known diabetes had a significant higher hazard of stroke, cardiovascular- and all-cause mortality.
Competing Interests: Declaration of competing interest None.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Atrial fibrillation; Diabetes; Hemoglobin A1c; Pre-diabetes
تواريخ الأحداث: Date Created: 20230813 Date Completed: 20230905 Latest Revision: 20230918
رمز التحديث: 20240628
DOI: 10.1016/j.jdiacomp.2023.108579
PMID: 37573645
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-460X
DOI:10.1016/j.jdiacomp.2023.108579