دورية أكاديمية
أعرض في EDS

Ophthalmic symptoms, clinical signs and diagnostic delay in infants diagnosed with brain tumours in Denmark between 2007 and 2017.

التفاصيل البيبلوغرافية
العنوان: Ophthalmic symptoms, clinical signs and diagnostic delay in infants diagnosed with brain tumours in Denmark between 2007 and 2017.
المؤلفون: Turanzas NJ; Department of Ophthalmology, Copenhagen University Hospital, Copenhagen, Denmark., Mathiasen R; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Denmark., Heegaard S; Department of Ophthalmology, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark.; Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark., Schmiegelow K; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Denmark.; Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark., Sehested A; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Denmark., Holtz JK; Department of Ophthalmology, Odense University Hospital, Odense, Denmark., Siersma V; The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Nissen KR; Department of Ophthalmology, Copenhagen University Hospital, Copenhagen, Denmark., von Holstein SL; Department of Ophthalmology, Copenhagen University Hospital, Copenhagen, Denmark.; Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark.
المصدر: Acta ophthalmologica [Acta Ophthalmol] 2024 May; Vol. 102 (3), pp. 334-341. Date of Electronic Publication: 2023 Aug 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101468102 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-3768 (Electronic) Linking ISSN: 1755375X NLM ISO Abbreviation: Acta Ophthalmol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, UK : Wiley-Blackwell
Original Publication: Oxford, UK ; Malden, MA : Blackwell Munksgaard
مواضيع طبية MeSH: Delayed Diagnosis* , Brain Neoplasms*/diagnosis , Brain Neoplasms*/epidemiology, Infant ; Child ; Humans ; Retrospective Studies ; Survival Rate ; Denmark/epidemiology ; Registries
مستخلص: Purpose: To investigate ophthalmic onset manifestations and the impact of diagnostic delay on the prognosis in infants (<1 year) diagnosed with a brain tumour.
Methods: A retrospective population-based nationwide study of infants diagnosed with a brain tumour between 2007 and 2017 in Denmark. Data was retrieved from the Danish Childhood Cancer Registry, the National Danish Health registries, and medical files. Primary outcome measures included symptoms, clinical findings, time to diagnosis and survival.
Results: Thirty-seven infants were diagnosed with a brain tumour in Denmark between 2007 and 2017. In total, 19/37 infants (51%, 95% CI: 34-68) had ophthalmic manifestations at any time prior to or at diagnosis; and in 6/37 (16%, 95% CI: 6-32) ophthalmic manifestations were the initial symptom. The most common ophthalmic manifestations were strabismus (n = 7), sunset eyes (n = 6), nystagmus (n = 4), reduced pupillary light reflex (n = 4), and/or decreased vision (n = 4). The median number of symptoms per infant at the time of diagnosis was three (range 0-9). The median diagnostic delay was 26 days (range 0-283, IQR: 6;90). 5-year survival rate was 75% (95% CI: 61-90) and all children with diagnostic delay > 100 days (n = 9, 24%) were still alive at the end of follow-up (median 6.3 years, range 2.2-10.2).
Conclusion: We provide an overview of symptoms and clinical signs in a nation-wide series of infants with CNS tumours and demonstrate that ophthalmic manifestations are frequently observed in infants prior to diagnosis, but, often in combination with other clinical signs. The diagnostic delay was substantial for a large part of the infants, but this was not associated with increased mortality.
(© 2023 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.)
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معلومات مُعتمدة: Børnecancerfonden; Doctor Emil Sofus Friis and wife Olga Doris Friis's Foundation; Ingeniør Otto Christensens Fond; Kraeftens Bekaempelse; Synoptik-Fonden; Kræftens Bekæmpelse
فهرسة مساهمة: Keywords: brain; central nervous system; infants; ophthalmic; symptoms; tumour
تواريخ الأحداث: Date Created: 20230814 Date Completed: 20240410 Latest Revision: 20240410
رمز التحديث: 20240410
DOI: 10.1111/aos.15745
PMID: 37574657
قاعدة البيانات: MEDLINE
الوصف
تدمد:1755-3768
DOI:10.1111/aos.15745