دورية أكاديمية
Periprosthetic effusions surrounding breast expander: a flow cytometric, immunohistochemical and molecular characterization.
| العنوان: | Periprosthetic effusions surrounding breast expander: a flow cytometric, immunohistochemical and molecular characterization. |
|---|---|
| المؤلفون: | Sala L; Department of Plastic Reconstructive Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy., Ciniselli CM; Unit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy., Bozzi F; Department of Diagnostics Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy., Summo V; Department of Plastic Reconstructive Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy., Bonini C; Unit of laboratory Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Lombardia, Italy., Brich S; Department of Diagnostics Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy., Bertolotti A; Department of Diagnostics Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy., Trupia DV; Department of Diagnostics Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy., Volpi CC; Department of Diagnostics Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy., Pizzamiglio S; Unit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy., Paolini B; Department of Diagnostics Innovation, Pathology Unit 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy., Aiello A; Department of Diagnostics Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy., Apolone G; Scientific Directorate, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy., Verderio P; Unit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy., Cortinovis U; Department of Plastic Reconstructive Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy. |
| المصدر: | Tumori [Tumori] 2024 Feb; Vol. 110 (1), pp. 49-59. Date of Electronic Publication: 2023 Aug 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Publications Country of Publication: United States NLM ID: 0111356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2038-2529 (Electronic) Linking ISSN: 03008916 NLM ISO Abbreviation: Tumori Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : Thousand Oaks, CA : Sage Publications Original Publication: Milano : Istituto nazionale per lo studio e la cura dei tumori |
| مواضيع طبية MeSH: | Breast Implants* , Mammaplasty*/methods , Breast Neoplasms*, Female ; Humans ; Inflammation |
| مستخلص: | Introduction: The synthesis of the periprosthetic capsule during implant-based breast reconstruction is the result of a coordinate cascade of inflammatory events ending in a fibrous tissue deposition around the expander or implant. Although the development of small volumes of fluid is one of the complications of prosthetic-based breast reconstruction, the characterization of the periprosthetic effusions coupled with the micro-textured devices, that have been recently introduced after the recall of macro-textured ones, is still lacking. The investigation of these periprosthetic effusions and paired capsules in terms of immunological content were the primary and secondary aims of the present study, respectively. Methods: For this, 68 women, 41 of whom had periprosthetic effusions at the time of expander replacement with implant, were recruited. For each case, capsule and healthy dermal tissues were taken and for women with periprosthetic effusion, peripheral blood was also collected. Periprosthetic effusions and peripheral blood were characterized by cytometry while capsules and dermal tissues by immunohistochemistry and Nanostring analysis. Results: The results showed an increase of Th1, Th2 lymphocytes and a HLA-DR+ bright CD16+ cells (likely representing monocytes-derived macrophages) in periprosthetic effusions in respect to peripheral blood. These pro-inflammatory cells were counterbalanced by the gain of suppressive CD4 Treg cells. In the corresponding capsules, immunohistochemistry revealed the absence of Th1 cells and the presence of tissutal FOXP3 Treg. No significant difference in expression of inflammatory-related genes between capsules and dermal tissues was present. Conclusions: These results suggest the presence of a Treg-controlled inflammation in both periprosthetic effusions and capsules. Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| فهرسة مساهمة: | Keywords: Periprosthetic effusion; breast expander; breast reconstruction; inflammation |
| تواريخ الأحداث: | Date Created: 20230814 Date Completed: 20240208 Latest Revision: 20240208 |
| رمز التحديث: | 20240208 |
| DOI: | 10.1177/03008916231189532 |
| PMID: | 37574933 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2038-2529 |
|---|---|
| DOI: | 10.1177/03008916231189532 |