دورية أكاديمية
Gold nanocluster-based fluorescent sensors for in vitro and in vivo ratiometric imaging of biomolecules.
| العنوان: | Gold nanocluster-based fluorescent sensors for in vitro and in vivo ratiometric imaging of biomolecules. |
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| المؤلفون: | Santhoshkumar S; Department of Chemistry, National Sun Yat-sen University, No. 70, Lien-hai Road, Gushan District, Kaohsiung 80424, Taiwan. tsengwl@mail.nsysu.edu.tw., Madhu M; Department of Chemistry, National Sun Yat-sen University, No. 70, Lien-hai Road, Gushan District, Kaohsiung 80424, Taiwan. tsengwl@mail.nsysu.edu.tw., Tseng WB; Department of Chemistry, National Sun Yat-sen University, No. 70, Lien-hai Road, Gushan District, Kaohsiung 80424, Taiwan. tsengwl@mail.nsysu.edu.tw.; Department of Environmental Engineering, Da-Yeh University, No. 168, University Rd., Dacun, Changhua 515006, Taiwan. tsengwb@mail.dyu.edu.tw., Tseng WL; Department of Chemistry, National Sun Yat-sen University, No. 70, Lien-hai Road, Gushan District, Kaohsiung 80424, Taiwan. tsengwl@mail.nsysu.edu.tw.; School of Pharmacy, Kaohsiung Medical University, No. 100, Shiquan 1st Road, Sanmin District, Kaohsiung 80708, Taiwan. |
| المصدر: | Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2023 Aug 23; Vol. 25 (33), pp. 21787-21801. Date of Electronic Publication: 2023 Aug 23. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 100888160 Publication Model: Electronic Cited Medium: Internet ISSN: 1463-9084 (Electronic) Linking ISSN: 14639076 NLM ISO Abbreviation: Phys Chem Chem Phys Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge [England] : Royal Society of Chemistry, c1999- |
| مواضيع طبية MeSH: | Metal Nanoparticles*/chemistry , Nanostructures*, Fluorescent Dyes/chemistry ; Gold/chemistry ; Reproducibility of Results ; Spectrometry, Fluorescence |
| مستخلص: | Gold nanoclusters (AuNCs) are promising nanomaterials for ratiometric fluorescent probes due to their tunable fluorescence wavelengths dependent on size and structure, as well as their biocompatibility and resistance to photobleaching. By incorporating an additional fluorescence spectral peak, dual-emission AuNC-based fluorescent probes have been developed to enhance the signal output reproducibility. These probes can be fabricated by integrating various luminescent nanomaterials with AuNCs. This review focuses on the preparation methods and applications of ratiometric fluorescent probes derived from AuNCs and other fluorescent nanomaterials or fluorescent dyes for both in vitro and in vivo bioimaging of target analytes. Additionally, the review delves into the sensing mechanisms of AuNC-based ratiometric probes, their synthetic strategies, and the challenges encountered when using AuNCs for ratiometric bioimaging. Moreover, we explore the application of protein-stabilized AuNCs and thiolate-capped AuNC-based ratiometric fluorescent probes for biosensing and bioimaging. Two primary methods for assembling AuNCs and fluorophores into ratiometric fluorescent probes are discussed: triggered assembly and self-assembly. Finally, we address the challenges and issues associated with ratiometric bioimaging using AuNCs and propose future directions for further advancing AuNCs as ratiometric imaging agents. |
| المشرفين على المادة: | 0 (Fluorescent Dyes) 7440-57-5 (Gold) |
| تواريخ الأحداث: | Date Created: 20230814 Date Completed: 20230824 Latest Revision: 20230824 |
| رمز التحديث: | 20230824 |
| DOI: | 10.1039/d3cp02714g |
| PMID: | 37577965 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1463-9084 |
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| DOI: | 10.1039/d3cp02714g |