دورية أكاديمية
Hyperprolactinemia modifies extracellular matrix components associated with collagen fibrillogenesis in harderian glands of non- and pregnant female mice.
| العنوان: | Hyperprolactinemia modifies extracellular matrix components associated with collagen fibrillogenesis in harderian glands of non- and pregnant female mice. |
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| المؤلفون: | Araujo ASL; Morphology and Genetics Department, Federal University of São Paulo, UNIFESP, Brazil., Simões MJ; Morphology and Genetics Department, Federal University of São Paulo, UNIFESP, Brazil; Faculty of Medicine University of São Paulo, Obstetrics and Gynecology Department, FMUSP, Brazil; Obstetrics and Gynecology Department, Federal University of São Paulo, UNIFESP, Brazil., Araujo-Jr OP; Obstetrics and Gynecology Department, Federal University of São Paulo, UNIFESP, Brazil., Simões RS; Faculty of Medicine University of São Paulo, Obstetrics and Gynecology Department, FMUSP, Brazil; Obstetrics and Gynecology Department, Federal University of São Paulo, UNIFESP, Brazil., Baracat EC; Faculty of Medicine University of São Paulo, Obstetrics and Gynecology Department, FMUSP, Brazil; Obstetrics and Gynecology Department, Federal University of São Paulo, UNIFESP, Brazil., Nader HB; Molecular Biology Division of the Department of Biochemistry, Federal University of São Paulo, Brazil., Soares-Jr JM; Faculty of Medicine University of São Paulo, Obstetrics and Gynecology Department, FMUSP, Brazil; Obstetrics and Gynecology Department, Federal University of São Paulo, UNIFESP, Brazil., Gomes RCT; Morphology and Genetics Department, Federal University of São Paulo, UNIFESP, Brazil; Faculty of Medicine University of São Paulo, Obstetrics and Gynecology Department, FMUSP, Brazil; Obstetrics and Gynecology Department, Federal University of São Paulo, UNIFESP, Brazil. Electronic address: celiateixeira2000@yahoo.com.br. |
| المصدر: | Experimental eye research [Exp Eye Res] 2023 Oct; Vol. 235, pp. 109612. Date of Electronic Publication: 2023 Aug 12. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: England NLM ID: 0370707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0007 (Electronic) Linking ISSN: 00144835 NLM ISO Abbreviation: Exp Eye Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Academic Press Original Publication: London. |
| مواضيع طبية MeSH: | Hyperprolactinemia*/chemically induced , Hyperprolactinemia*/metabolism , Harderian Gland*/metabolism, Pregnancy ; Humans ; Mice ; Female ; Animals ; Proteoglycans/metabolism ; Extracellular Matrix Proteins/metabolism ; Chondroitin Sulfate Proteoglycans/metabolism ; Decorin/metabolism ; Prolactin/adverse effects ; Prolactin/analysis ; Prolactin/metabolism ; Progesterone ; Collagen/metabolism ; Extracellular Matrix/metabolism ; Estrogens/adverse effects ; Estrogens/analysis ; Estrogens/metabolism |
| مستخلص: | The harderian gland (HG) is a gland located at the base of the nictating membrane and fills the inferomedial aspect of the orbit in rodents. It is under the influence of the hypothalamic-pituitary-gonadal axis and, because of its hormone receptors, it is a target tissue for prolactin (PRL) and sex steroid hormones (estrogen and progesterone). In humans and murine, the anterior surface of the eyes is protected by a tear film synthesized by glands associated with the eye. In order to understand the endocrine changes caused by hyperprolactinemia in the glands responsible for the formation of the tear film, we used an animal model with metoclopramide-induced hyperprolactinemia (HPRL). Given the evidences that HPRL can lead to a process of cell death and tissue fibrosis, the protein expression of small leucine-rich proteoglycans (SLRPs) was analyzed through immunohistochemistry in the HG of the non- and the pregnant female mice with hyperprolactinemia. The SRLPs are related to collagen fibrillogenesis and they participate in pro-apoptotic signals. Our data revealed that high prolactin levels and changes in steroid hormones (estrogen and progesterone) can lead to an alteration in the amount of collagen, and in the structure of type I and III collagen fibers through changes in the amounts of lumican and decorin, which are responsible for collagen fibrillogenesis. This fact can lead to the impaired functioning of the HG by excessive apoptosis in the HG of the non- and the pregnant female mice with HPRL and especially in the HG of pregnancy-associated hyperprolactinemia. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Collagen; Decorin and lumican; Harderian glands; Hyperprolactinemia; Ki67; TUNEL |
| المشرفين على المادة: | 0 (Proteoglycans) 0 (Extracellular Matrix Proteins) 0 (Chondroitin Sulfate Proteoglycans) 0 (Decorin) 9002-62-4 (Prolactin) 4G7DS2Q64Y (Progesterone) 9007-34-5 (Collagen) 0 (Estrogens) |
| تواريخ الأحداث: | Date Created: 20230814 Date Completed: 20230925 Latest Revision: 20230925 |
| رمز التحديث: | 20230926 |
| DOI: | 10.1016/j.exer.2023.109612 |
| PMID: | 37580001 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-0007 |
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| DOI: | 10.1016/j.exer.2023.109612 |