دورية أكاديمية
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Mediating role of atherogenic lipoproteins in the relationship between liver fat and coronary artery calcification.

التفاصيل البيبلوغرافية
العنوان: Mediating role of atherogenic lipoproteins in the relationship between liver fat and coronary artery calcification.
المؤلفون: Björnson E; Wallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, University of Gothenburg, 413 45, Gothenburg, Sweden. elias.bjornson@wlab.gu.se., Samaras D; Wallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, University of Gothenburg, 413 45, Gothenburg, Sweden., Adiels M; Wallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, University of Gothenburg, 413 45, Gothenburg, Sweden.; School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden., Kullberg J; Section of Radiology, Department of Surgical Sciences, Uppsala University, 752 37, Uppsala, Sweden.; Antaros Medical, 431 83, Mölndal, Sweden., Bäckhed F; Wallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, University of Gothenburg, 413 45, Gothenburg, Sweden.; Department of Clinical Physiology, Sahlgrenska University Hospital, Region Västra Götaland, 413 45, Gothenburg, Sweden., Bergström G; Wallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, University of Gothenburg, 413 45, Gothenburg, Sweden.; Department of Clinical Physiology, Sahlgrenska University Hospital, Region Västra Götaland, 413 45, Gothenburg, Sweden., Gummesson A; Wallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, University of Gothenburg, 413 45, Gothenburg, Sweden.; Department of Clinical Genetics, Sahlgrenska University Hospital, Region Västra Götaland, 413 45, Gothenburg, Sweden.
المصدر: Scientific reports [Sci Rep] 2023 Aug 14; Vol. 13 (1), pp. 13217. Date of Electronic Publication: 2023 Aug 14.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Coronary Artery Disease* , Non-alcoholic Fatty Liver Disease*/complications , Atherosclerosis*, Male ; Middle Aged ; Humans ; Female ; Lipoproteins ; Triglycerides ; Cholesterol ; Apolipoproteins B ; Cholesterol, LDL
مستخلص: Non-alcoholic fatty liver disease (NAFLD) is associated with increased secretion of apoB-containing lipoproteins and increased risk of coronary heart disease (CHD). ApoB-containing lipoproteins include low-density lipoproteins (LDLs) and triglyceride-rich lipoproteins (TRLs); and since both LDLs and TRLs are causally related to CHD, they may mediate a portion of the increased risk of atherosclerosis seen in people with NAFLD. In a cohort of 4161 middle aged men and women, we performed mediation analysis in order to quantify the mediating effect of apoB-containing lipoproteins in the relationship between liver fat and atherosclerosis-as measured by coronary artery calcium score (CACS). We found plasma apoB to mediate 17.6% (95% CI 11-24) of the association between liver fat and CACS. Plasma triglycerides and TRL-cholesterol (both proximate measures of TRL particles) mediated 22.3% (95% CI 11-34) and 21.6% (95% CI 10-33) of the association respectively; whereas LDL-cholesterol mediated 5.4% (95% CI 2.0-9.4). In multivariable models, the mediating effect of TRL-cholesterol and plasma triglycerides showed, again, a higher degree of mediation than LDL-cholesterol, corroborating the results seen in the univariable models. In summary, we find around 20% of the association between liver fat and CACS to be mediated by apoB-containing lipoproteins. In addition, we find that TRLs mediate the majority of this effect whereas LDLs mediate a smaller effect. These results explain part of the observed CAD-risk burden for people with NAFLD and further suggest that TRL-lowering may be particularly beneficial to mitigate NAFLD-associated coronary artery disease risk.
(© 2023. Springer Nature Limited.)
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المشرفين على المادة: 0 (Lipoproteins)
0 (Triglycerides)
97C5T2UQ7J (Cholesterol)
0 (Apolipoproteins B)
0 (Cholesterol, LDL)
تواريخ الأحداث: Date Created: 20230814 Date Completed: 20230816 Latest Revision: 20231122
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10425432
DOI: 10.1038/s41598-023-39390-1
PMID: 37580332
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-023-39390-1