دورية أكاديمية
Nonselective Expression of Short-Wavelength Cone Opsin Improves Learning in Mice with Retinal Degeneration in a Visually Guided Task.
| العنوان: | Nonselective Expression of Short-Wavelength Cone Opsin Improves Learning in Mice with Retinal Degeneration in a Visually Guided Task. |
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| المؤلفون: | Idzhilova OS; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia.; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia., Kolotova DE; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia.; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia., Smirnova GR; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia.; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia., Abonakour A; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia.; Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow Oblast, Russia., Dolgikh DA; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.; Biological Faculty, Moscow State University, Moscow, Russia., Petrovskaya LE; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia., Kirpichnikov MP; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.; Biological Faculty, Moscow State University, Moscow, Russia., Ostrovsky MA; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.; Biological Faculty, Moscow State University, Moscow, Russia., Malyshev AY; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia. malyshev@ihna.ru. |
| المصدر: | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections [Dokl Biol Sci] 2023 Jun; Vol. 510 (1), pp. 167-171. Date of Electronic Publication: 2023 Aug 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Consultants Bureau Country of Publication: United States NLM ID: 7505459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1608-3105 (Electronic) Linking ISSN: 00124966 NLM ISO Abbreviation: Dokl Biol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, Consultants Bureau c1965- |
| مواضيع طبية MeSH: | Cone Opsins*/genetics , Cone Opsins*/metabolism , Retinal Degeneration*/genetics , Retinal Degeneration*/metabolism, Mice ; Animals ; Retinal Cone Photoreceptor Cells/metabolism ; Retina ; Opsins/metabolism ; Mice, Knockout |
| مستخلص: | The study explored the potential of an animal opsin nonselectively expressed in various neuronal elements of the degenerative retina to restore the impaired visual function. A knockout murine model of inherited retinal dystrophy was used. Mice were injected intravitreally with either a virus carrying the gene of short-wavelength cone opsin associated with a reporter fluorescent protein or a control virus carrying the sequence of a modified fluorescent protein with enhanced membrane tropism. Viral transduction induced pronounced opsin expression in ganglion, bipolar, and horizontal retinal neurons. Behavioral testing included the visually guided task in the trapezoid Morris water maze and showed a partial recovery of the learning ability in the mice whose retinas had been transduced with cone opsin. (© 2023. Pleiades Publishing, Ltd.) |
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| فهرسة مساهمة: | Keywords: adeno-associated viruses; cone opsin; optogenetic prosthetics; retinal degeneration |
| المشرفين على المادة: | 0 (Cone Opsins) 0 (Opsins) |
| تواريخ الأحداث: | Date Created: 20230815 Date Completed: 20230817 Latest Revision: 20230817 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1134/S0012496623700369 |
| PMID: | 37582993 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1608-3105 |
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| DOI: | 10.1134/S0012496623700369 |