دورية أكاديمية
Neural dynamics in the limbic system during male social behaviors.
| العنوان: | Neural dynamics in the limbic system during male social behaviors. |
|---|---|
| المؤلفون: | Guo Z; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, USA; School of Life Sciences, Peking University, Beijing 100871, China., Yin L; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, USA., Diaz V; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, USA., Dai B; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, USA., Osakada T; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, USA., Lischinsky JE; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, USA., Chien J; Department of Psychiatry, Department of Neuroscience and Physiology, New York University Grossman School of Medicine, Center for Neural Science, New York University, New York, NY 10016, USA., Yamaguchi T; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, USA., Urtecho A; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, USA., Tong X; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, USA., Chen ZS; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, USA; Department of Psychiatry, Department of Neuroscience and Physiology, New York University Grossman School of Medicine, Center for Neural Science, New York University, New York, NY 10016, USA; Department of Biomedical Engineering, New York University Tandon School of Engineering, New York, NY 11201, USA., Lin D; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, USA; Department of Psychiatry, Department of Neuroscience and Physiology, New York University Grossman School of Medicine, Center for Neural Science, New York University, New York, NY 10016, USA. Electronic address: dayu.lin@nyulangone.org. |
| المصدر: | Neuron [Neuron] 2023 Oct 18; Vol. 111 (20), pp. 3288-3306.e4. Date of Electronic Publication: 2023 Aug 15. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, Mass. : Cell Press, c1988- |
| مواضيع طبية MeSH: | Social Behavior* , Limbic System*/physiology, Male ; Animals ; Mice ; Aggression/physiology ; Sexual Behavior, Animal/physiology |
| مستخلص: | Sexual and aggressive behaviors are vital for species survival and individual reproductive success. Although many limbic regions have been found relevant to these behaviors, how social cues are represented across regions and how the network activity generates each behavior remains elusive. To answer these questions, we utilize multi-fiber photometry (MFP) to simultaneously record Ca 2+ signals of estrogen receptor alpha (Esr1)-expressing cells from 13 limbic regions in male mice during mating and fighting. We find that conspecific sensory information and social action signals are widely distributed in the limbic system and can be decoded from the network activity. Cross-region correlation analysis reveals striking increases in the network functional connectivity during the social action initiation phase, whereas late copulation is accompanied by a "dissociated" network state. Based on the response patterns, we propose a mating-biased network (MBN) and an aggression-biased network (ABN) for mediating male sexual and aggressive behaviors, respectively. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
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| معلومات مُعتمدة: | R01 HD092596 United States HD NICHD NIH HHS; R01 MH101377 United States MH NIMH NIH HHS; R01 MH118928 United States MH NIMH NIH HHS; K99 MH127295 United States MH NIMH NIH HHS; RF1 DA056394 United States DA NIDA NIH HHS; R01 MH124927 United States MH NIMH NIH HHS; U19 NS107616 United States NS NINDS NIH HHS |
| فهرسة مساهمة: | Keywords: aggression; estrogen receptor alpha expressing cells; limbic system; mice; multi-fiber photometric recording; sexual behaviors |
| تواريخ الأحداث: | Date Created: 20230816 Date Completed: 20231023 Latest Revision: 20231121 |
| رمز التحديث: | 20240514 |
| مُعرف محوري في PubMed: | PMC10592239 |
| DOI: | 10.1016/j.neuron.2023.07.011 |
| PMID: | 37586365 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1097-4199 |
|---|---|
| DOI: | 10.1016/j.neuron.2023.07.011 |