دورية أكاديمية
أعرض في EDS

Associations between placental pathology and poor intrauterine growth among a cohort of mother-infant singleton pairs in Leyte, the Philippines.

التفاصيل البيبلوغرافية
العنوان: Associations between placental pathology and poor intrauterine growth among a cohort of mother-infant singleton pairs in Leyte, the Philippines.
المؤلفون: Colt S; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.; Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA., Barry CV; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA., Sagliba MJ; Research Institute of Tropical Medicine, Manila, Philippines., Amoylen AJ; Research Institute of Tropical Medicine, Manila, Philippines., Tallo V; Research Institute of Tropical Medicine, Manila, Philippines., Friedman JF; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.; Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA., Gundogan F; Department of Pathology and Laboratory Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA., McDonald EA; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.; Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
المصدر: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2024 Feb; Vol. 164 (2), pp. 750-757. Date of Electronic Publication: 2023 Aug 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0210174 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3479 (Electronic) Linking ISSN: 00207292 NLM ISO Abbreviation: Int J Gynaecol Obstet Subsets: MEDLINE
أسماء مطبوعة: Publication: 2017- : Malden, MA : Wiley
Original Publication: [New York, NY] Hoeber Medical Division, Harper & Row, [c1969-
مواضيع طبية MeSH: Placenta*/blood supply , Fetal Nutrition Disorders*/pathology, Infant, Newborn ; Child ; Pregnancy ; Female ; Humans ; Pregnancy Outcome/epidemiology ; Mothers ; Philippines/epidemiology ; Retrospective Studies ; Fetal Growth Retardation/epidemiology ; Fetal Growth Retardation/etiology
مستخلص: Objective: Poor intrauterine growth has negative impacts for child growth and development and disproportionately affects children living in low-resource settings. In the present study, we investigated relationships between placental pathologies and indicators of poor intrauterine growth.
Methods: We enrolled a longitudinal cohort of 279 mother-infant pairs from Leyte, the Philippines. Placental measures included characteristics, pathological findings, and immunohistochemistry. At birth, intrauterine growth was assessed using anthropometric measures, weight-for-gestational age, and the clinical assessment of nutritional status score (CANSCORE) for determining fetal malnutrition. Multivariate linear regression and log-binomial regression models were applied, controlling for potential confounding factors.
Results: Maternal vascular malperfusion (MVM) was related to reduced birthweight (P < 0.0001), birth length (P = 0.002), head circumference (P = 0.001), and weight-to-length ratio (P = 0.016). MVM increased the risk for preterm delivery (P = 0.0005) and small for gestational age (SGA) (P = 0.016). Acute chorioamnionitis (P = 0.013) and MVM (P = 0.021) both led to an increased risk for fetal malnutrition defined by CANSORE<25. Villous tissue activated caspase-3 was associated with lower birth length (P = 0.0006), higher weight-to-length ratio (P = 0.004), reduced risks for SGA (P = 0.011) and low weight-to-length ratio for gestational age (P = 0.004).
Conclusion: The present study applied comprehensive measures for intrauterine growth and demonstrates that low placental weight and placental pathology, chiefly MVM, contribute to poor intrauterine growth. A better understanding of the mechanistic role of specific placental pathologies on adverse newborn outcomes will provide opportunities for reducing incidence of poor intrauterine growth and associated long-term morbidities.
(© 2023 International Federation of Gynecology and Obstetrics.)
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معلومات مُعتمدة: K01 AI113068 United States AI NIAID NIH HHS; K24 AI112964 United States AI NIAID NIH HHS; R01 AA024092 United States AA NIAAA NIH HHS; U01 AA024092 United States AA NIAAA NIH HHS
فهرسة مساهمة: Keywords: acute chorioamnionitis; fetal malnutrition; intrauterine growth; maternal vascular; placenta malperfusion
تواريخ الأحداث: Date Created: 20230817 Date Completed: 20240115 Latest Revision: 20240207
رمز التحديث: 20240207
مُعرف محوري في PubMed: PMC10841323
DOI: 10.1002/ijgo.15047
PMID: 37589399
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-3479
DOI:10.1002/ijgo.15047