دورية أكاديمية
أعرض في EDS

Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary gland.

التفاصيل البيبلوغرافية
العنوان: Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary gland.
المؤلفون: Scagliotti V; Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Vignola ML; Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Willis T; Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.; Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, United Kingdom., Howard M; MRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London, United Kingdom., Marinelli E; Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Gaston-Massuet C; Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Andoniadou C; Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, United Kingdom., Charalambous M; Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
المصدر: ELife [Elife] 2023 Aug 17; Vol. 12. Date of Electronic Publication: 2023 Aug 17.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Calcium-Binding Proteins*/genetics , Cell Communication* , Pituitary Gland* , Gene Dosage*, Animals ; Humans ; Mice ; Biological Transport ; Body Size ; Cell Differentiation
مستخلص: Co-regulated genes of the Imprinted Gene Network are involved in the control of growth and body size, and imprinted gene dysfunction underlies human paediatric disorders involving the endocrine system. Imprinted genes are highly expressed in the pituitary gland, among them, Dlk1 , a paternally expressed gene whose membrane-bound and secreted protein products can regulate proliferation and differentiation of multiple stem cell populations. Dosage of circulating DLK1 has been previously implicated in the control of growth through unknown molecular mechanisms. Here we generate a series of mouse genetic models to modify levels of Dlk1 expression in the pituitary gland and demonstrate that the dosage of DLK1 modulates the process of stem cell commitment with lifelong impact on pituitary gland size. We establish that stem cells are a critical source of DLK1, where embryonic disruption alters proliferation in the anterior pituitary, leading to long-lasting consequences on growth hormone secretion later in life.
Competing Interests: VS, MV, TW, MH, EM, CG, CA, MC No competing interests declared
(© 2023, Scagliotti et al.)
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معلومات مُعتمدة: MR/L002345/1 United Kingdom MRC_ Medical Research Council; MR/R022836/1 United Kingdom MRC_ Medical Research Council; MR/T012153/1 United Kingdom MRC_ Medical Research Council; United Kingdom DH_ Department of Health; United Kingdom WT_ Wellcome Trust
فهرسة مساهمة: Keywords: Dlk1; Sox2; developmental biology; growth hormone; imprinting; mouse; pituitary gland; regenerative medicine; stem cell; stem cells
سلسلة جزيئية: GEO GSE120410; GSE142074; GSE178454
المشرفين على المادة: 0 (Calcium-Binding Proteins)
0 (Dlk1 protein, mouse)
تواريخ الأحداث: Date Created: 20230817 Date Completed: 20230912 Latest Revision: 20230912
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10468206
DOI: 10.7554/eLife.84092
PMID: 37589451
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.84092