دورية أكاديمية
أعرض في EDS

DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans .

التفاصيل البيبلوغرافية
العنوان: DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans .
المؤلفون: Xia Y; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK., Sonneville R; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK., Jenkyn-Bedford M; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK., Ji L; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao, China., Alabert C; Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK., Hong Y; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao, China., Yeeles JTP; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK., Labib KPM; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
المصدر: Science (New York, N.Y.) [Science] 2023 Sep 22; Vol. 381 (6664), pp. eadi4932. Date of Electronic Publication: 2023 Sep 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
أسماء مطبوعة: Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-
مواضيع طبية MeSH: Caenorhabditis elegans*/genetics , Caenorhabditis elegans*/metabolism , DNA Replication* , Minichromosome Maintenance Proteins*/chemistry , Minichromosome Maintenance Proteins*/genetics , Minichromosome Maintenance Proteins*/metabolism , Caenorhabditis elegans Proteins*/chemistry , Caenorhabditis elegans Proteins*/genetics , Caenorhabditis elegans Proteins*/metabolism, Animals ; Cell Cycle Proteins/metabolism ; Cryoelectron Microscopy ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/metabolism ; Protein Domains
مستخلص: Assembly of the CMG (CDC-45-MCM-2-7-GINS) helicase is the key regulated step during eukaryotic DNA replication initiation. Until now, it was unclear whether metazoa require additional factors that are not present in yeast. In this work, we show that Caenorhabditis elegans DNSN-1, the ortholog of human DONSON, functions during helicase assembly in a complex with MUS-101/TOPBP1. DNSN-1 is required to recruit the GINS complex to chromatin, and a cryo-electron microscopy structure indicates that DNSN-1 positions GINS on the MCM-2-7 helicase motor (comprising the six MCM-2 to MCM-7 proteins), by direct binding of DNSN-1 to GINS and MCM-3, using interfaces that we show are important for initiation and essential for viability. These findings identify DNSN-1 as a missing link in our understanding of DNA replication initiation, suggesting that initiation defects underlie the human disease syndrome that results from DONSON mutations.
References: Protein Sci. 2018 Jan;27(1):293-315. (PMID: 29067766)
Structure. 2014 Sep 2;22(9):1341-1347. (PMID: 25126958)
PLoS Genet. 2020 Dec 15;16(12):e1008948. (PMID: 33320862)
Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10236-10241. (PMID: 16798881)
Protein Sci. 2021 Jan;30(1):70-82. (PMID: 32881101)
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501. (PMID: 20383002)
Biochem J. 2021 Dec 22;478(24):4169-4185. (PMID: 34783343)
Nature. 2022 Jun;606(7916):1007-1014. (PMID: 35705812)
Nat Commun. 2020 Aug 7;11(1):3951. (PMID: 32769987)
Nat Struct Biol. 2003 Dec;10(12):980. (PMID: 14634627)
Nature. 2013 Mar 21;495(7441):339-43. (PMID: 23474987)
Nature. 2007 Jan 18;445(7125):281-5. (PMID: 17167417)
Nat Cell Biol. 2017 May;19(5):468-479. (PMID: 28368371)
EMBO J. 2012 May 2;31(9):2195-206. (PMID: 22433841)
Curr Biol. 2012 Feb 21;22(4):343-9. (PMID: 22285032)
Cell Rep. 2015 Jul 21;12(3):405-17. (PMID: 26166571)
Curr Biol. 2005 Apr 26;15(8):755-9. (PMID: 15854909)
Nat Rev Mol Cell Biol. 2017 Aug;18(8):507-516. (PMID: 28537574)
J Struct Biol. 2004 Nov;148(2):194-204. (PMID: 15477099)
Methods Enzymol. 2010;481:109-26. (PMID: 20887855)
Cell. 2019 Jul 25;178(3):600-611.e16. (PMID: 31348887)
J Struct Biol. 2007 Jan;157(1):38-46. (PMID: 16859925)
Nat Cell Biol. 2006 Apr;8(4):358-66. (PMID: 16531994)
Genetics. 2005 Mar;169(3):1451-60. (PMID: 15654100)
Curr Biol. 2010 Jun 22;20(12):R509-10. (PMID: 20620901)
Genome Res. 2017 Aug;27(8):1323-1335. (PMID: 28630177)
Nature. 2022 Jun;606(7912):204-210. (PMID: 35585232)
J Comput Chem. 2004 Oct;25(13):1605-12. (PMID: 15264254)
EMBO J. 2001 Apr 17;20(8):2097-107. (PMID: 11296242)
Mol Cell. 2017 Jan 5;65(1):117-130. (PMID: 27989438)
Nucleic Acids Res. 2015 Oct 15;43(18):8830-8. (PMID: 26250113)
J Struct Biol. 2015 Nov;192(2):216-21. (PMID: 26278980)
Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20240-5. (PMID: 19910535)
Nucleic Acids Res. 2020 Jul 9;48(12):6980-6995. (PMID: 32453425)
DNA Repair (Amst). 2021 Dec;108:103232. (PMID: 34678589)
Nat Methods. 2022 Jun;19(6):679-682. (PMID: 35637307)
Elife. 2019 Sep 23;8:. (PMID: 31545170)
EMBO J. 2021 Sep 1;40(17):e108053. (PMID: 34269473)
Genes (Basel). 2021 Nov 29;12(12):. (PMID: 34946868)
G3 (Bethesda). 2018 Mar 2;8(3):967-979. (PMID: 29367452)
Nature. 2007 Jan 18;445(7125):328-32. (PMID: 17167415)
Mol Cell. 2017 Jan 5;65(1):105-116. (PMID: 27989442)
EMBO J. 2023 Sep 4;42(17):e114131. (PMID: 37458194)
Mol Cell. 2023 Aug 17;83(16):2911-2924.e16. (PMID: 37506699)
Biochimie. 1999 Aug-Sep;81(8-9):859-71. (PMID: 10572299)
Biochim Biophys Acta. 2011 Mar;1813(3):473-9. (PMID: 21256165)
Genes Dev. 2009 Mar 1;23(5):643-54. (PMID: 19270162)
G3 (Bethesda). 2016 Oct 13;6(10):3431-3442. (PMID: 27543292)
Genetics. 2016 Jul;203(3):1027-67. (PMID: 27384026)
Mol Cell. 2020 Jun 4;78(5):926-940.e13. (PMID: 32369734)
Acta Crystallogr D Struct Biol. 2018 Jun 1;74(Pt 6):531-544. (PMID: 29872004)
Cell. 2009 Nov 13;139(4):719-30. (PMID: 19896182)
Nature. 2021 Aug;596(7873):583-589. (PMID: 34265844)
Mol Cell Biol. 2013 Jul;33(13):2614-22. (PMID: 23629628)
Nature. 2015 Mar 26;519(7544):431-5. (PMID: 25739503)
Nucleic Acids Res. 2022 Jan 7;50(D1):D439-D444. (PMID: 34791371)
Biochem Soc Trans. 2020 Jun 30;48(3):823-836. (PMID: 32490508)
J Cell Biol. 2014 Feb 17;204(4):507-22. (PMID: 24535824)
Nature. 2003 Jan 16;421(6920):231-7. (PMID: 12529635)
EMBO J. 2016 May 2;35(9):961-73. (PMID: 26912723)
Science. 2023 Sep 22;381(6664):eadi3448. (PMID: 37590370)
EMBO J. 2021 Dec 1;40(23):e108819. (PMID: 34694004)
Elife. 2020 Aug 17;9:. (PMID: 32804080)
Genetics. 1974 May;77(1):71-94. (PMID: 4366476)
Curr Biol. 2014 May 19;24(10):R435-44. (PMID: 24845676)
Nature. 2022 May;605(7909):357-365. (PMID: 35508654)
Annu Rev Biochem. 2022 Jun 21;91:107-131. (PMID: 35320688)
Cell. 2010 Feb 5;140(3):349-59. (PMID: 20116089)
Acta Crystallogr D Struct Biol. 2018 Jun 1;74(Pt 6):519-530. (PMID: 29872003)
Nature. 2018 Mar 8;555(7695):265-268. (PMID: 29489749)
Nat Genet. 2017 Apr;49(4):537-549. (PMID: 28191891)
Nucleic Acids Res. 2022 Jan 7;50(D1):D543-D552. (PMID: 34723319)
Nat Methods. 2017 Apr;14(4):331-332. (PMID: 28250466)
Annu Rev Pathol. 2015;10:425-48. (PMID: 25621662)
PLoS One. 2012;7(11):e49505. (PMID: 23166690)
Nat Genet. 1999 May;22(1):82-4. (PMID: 10319867)
Cell. 2005 Jun 17;121(6):887-98. (PMID: 15960976)
Cell. 2011 Jul 8;146(1):80-91. (PMID: 21729781)
Mol Cell Biol. 2006 Jul;26(13):4843-52. (PMID: 16782873)
Genes Dev. 2010 Mar 15;24(6):602-12. (PMID: 20231317)
Protein Sci. 2018 Jan;27(1):14-25. (PMID: 28710774)
معلومات مُعتمدة: 24558 United Kingdom CRUK_ Cancer Research UK; MC_UU_12016/13 United Kingdom MRC_ Medical Research Council; MC_UP_1201/12 United Kingdom MRC_ Medical Research Council; 21782 United Kingdom CRUK_ Cancer Research UK; MC_UU_00018/4 United Kingdom MRC_ Medical Research Council
المشرفين على المادة: 0 (Cell Cycle Proteins)
0 (evl-18 protein, C elegans)
EC 3.6.4.12 (Minichromosome Maintenance Proteins)
0 (Caenorhabditis elegans Proteins)
0 (Chromosomal Proteins, Non-Histone)
تواريخ الأحداث: Date Created: 20230817 Date Completed: 20230926 Latest Revision: 20240313
رمز التحديث: 20240313
مُعرف محوري في PubMed: PMC7615117
DOI: 10.1126/science.adi4932
PMID: 37590372
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-9203
DOI:10.1126/science.adi4932