دورية أكاديمية
Preeclampsia to COVID-19: A journey towards improved placental and vascular function using sulforaphane.
| العنوان: | Preeclampsia to COVID-19: A journey towards improved placental and vascular function using sulforaphane. |
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| المؤلفون: | Fields NJ; The Ritchie Centre, Department of Obstetrics and Gynaecology, School of Clinical Sciences, Monash University, 27-31 Wright Street, Clayton, Victoria, Australia; Monash Health, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, Australia. Electronic address: neville.fields1@monash.edu., Palmer KR; The Ritchie Centre, Department of Obstetrics and Gynaecology, School of Clinical Sciences, Monash University, 27-31 Wright Street, Clayton, Victoria, Australia; Monash Health, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, Australia., Nisi A; The Ritchie Centre, Department of Obstetrics and Gynaecology, School of Clinical Sciences, Monash University, 27-31 Wright Street, Clayton, Victoria, Australia., Marshall SA; The Ritchie Centre, Department of Obstetrics and Gynaecology, School of Clinical Sciences, Monash University, 27-31 Wright Street, Clayton, Victoria, Australia. |
| المصدر: | Placenta [Placenta] 2023 Sep 26; Vol. 141, pp. 84-93. Date of Electronic Publication: 2023 Aug 12. |
| نوع المنشور: | Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8006349 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3102 (Electronic) Linking ISSN: 01434004 NLM ISO Abbreviation: Placenta Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2010- > : Amsterdam : Elsevier Original Publication: London W.B. Saunders. |
| مواضيع طبية MeSH: | Pre-Eclampsia*/metabolism , COVID-19*/metabolism, Infant, Newborn ; Pregnancy ; Female ; Humans ; Placenta/metabolism ; Antioxidants/therapeutic use ; Antioxidants/metabolism |
| مستخلص: | Excess inflammation and oxidative stress are common themes in many pathologies of pregnancy including preeclampsia and more recently severe COVID-19. The risk of preeclampsia increases following maternal infection with COVID-19, potentially relating to significant overlap in pathophysiology with endothelial, vascular and immunological dysfunction common to both. Identifying a therapy which addresses these injurious processes and stabilises the endothelial and vascular maternal system would help address the significant global burden of maternal and neonatal morbidity and mortality they cause. Sulforaphane is a naturally occurring phytonutrient found most densely within cruciferous vegetables. It has anti-inflammatory, antioxidant and immune modulating properties via upregulation of phase-II detoxification enzymes. This review will cover the common pathways shared by COVID-19 and preeclampsia and offer a potential therapeutic target via nuclear factor erythroid 2-related factor upregulation in the form of sulforaphane. Competing Interests: Declaration of competing interest All authors disclose no conflicts of interest. (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| المشرفين على المادة: | GA49J4310U (sulforaphane) 0 (Antioxidants) |
| تواريخ الأحداث: | Date Created: 20230817 Date Completed: 20230925 Latest Revision: 20231002 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.placenta.2023.08.063 |
| PMID: | 37591715 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-3102 |
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| DOI: | 10.1016/j.placenta.2023.08.063 |