دورية أكاديمية
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Structural and functional characterization of Aedes aegypti pupal cuticle protein that controls dengue virus infection.

التفاصيل البيبلوغرافية
العنوان: Structural and functional characterization of Aedes aegypti pupal cuticle protein that controls dengue virus infection.
المؤلفون: Huang Q; Department of Biological Sciences, National University of Singapore, Singapore, Singapore., Gavor E; Department of Biological Sciences, National University of Singapore, Singapore, Singapore., Tulsian NK; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, National University of Singapore, Singapore, Singapore., Fan J; Department of Biological Sciences, National University of Singapore, Singapore, Singapore., Lin Q; Department of Biological Sciences, National University of Singapore, Singapore, Singapore., Mok YK; Department of Biological Sciences, National University of Singapore, Singapore, Singapore., Kini RM; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Sivaraman J; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
المصدر: Protein science : a publication of the Protein Society [Protein Sci] 2023 Oct; Vol. 32 (10), pp. e4761.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: 2001- : Woodbury, NY : Cold Spring Harbor Laboratory Press
Original Publication: New York, N.Y. : Cambridge University Press, c1992-
مواضيع طبية MeSH: Dengue* , Dengue Virus*/physiology , Aedes*, Animals ; Humans ; Pupa ; Mosquito Vectors
مستخلص: The pupal cuticle protein from Aedes aegypti (AaPC) inhibits dengue virus (DENV) infection; however, the underlying mechanism of this inhibition remains unknown. Here, we report that AaPC is an intrinsically disordered protein and interacts with domain I/II of the DENV envelope protein via residues Asp59, Asp61, Glu71, Asp73, Ser75, and Asp80. AaPC can directly bind to and cause the aggregation of DENV, which in turn blocks virus infection during the virus-cell fusion stage. AaPC may also influence viral recognition and attachment by interacting with human immune receptors DC-SIGN and CD4. These findings enhance our understanding of the role of AaPC in mitigating viral infection and suggest that AaPC is a potential target for developing inhibitors or antibodies to control dengue virus infection.
(© 2023 The Protein Society.)
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فهرسة مساهمة: Keywords: Cuticular proteins; aggregation; dengue virus; intrinsically disordered; structure
تواريخ الأحداث: Date Created: 20230818 Date Completed: 20231023 Latest Revision: 20231101
رمز التحديث: 20231101
مُعرف محوري في PubMed: PMC10510476
DOI: 10.1002/pro.4761
PMID: 37593853
قاعدة البيانات: MEDLINE
الوصف
تدمد:1469-896X
DOI:10.1002/pro.4761