دورية أكاديمية
Medicinal (Radio)Chemistry: Building Radiopharmaceuticals for the Future.
| العنوان: | Medicinal (Radio)Chemistry: Building Radiopharmaceuticals for the Future. |
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| المؤلفون: | Pijeira MSO; Nuclear Engineering Institute IEN Rio de Janeiro Brazil., Nunes PSG; Laboratório Biosintesis P&D Bioengineering São Paulo Brazil., Chaviano SL; Centre Hospitalier de l'Université de Montréal Radiopharmacy Montreal Canada., Diaz AMA; Centre Hospitalier de l'Université de Montréal Radiopharmacy Montreal Canada., DaSilva JN; University of Montreal Radiopharmacy Montreal Canada., Ricci-Junior E; Universidade Federal do Rio de Janeiro Faculty of Pharmacy Rio de Janeiro Brazil., Alencar LMR; Federal University of Maranhão Physics São Luís Brazil., Chen X; Nanyang Technological University Radiopharmacy Singapore Singapore., Santos-Oliveira R; Nuclear Engineering Institute Laboratory of Radiopharmacy and Nanoradiopharmaceuticals Rio de Janeiro Brazil. |
| المصدر: | Current medicinal chemistry [Curr Med Chem] 2023 Aug 18. Date of Electronic Publication: 2023 Aug 18. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9440157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-533X (Electronic) Linking ISSN: 09298673 NLM ISO Abbreviation: Curr Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers Original Publication: Schiphol, The Netherlands : Bentham Science Publishers, |
| مستخلص: | Radiopharmaceuticals are increasingly playing a leading role in diagnosing, monitoring, and treating disease. In comparison with conventional pharmaceuticals, the development of radiopharmaceuticals does follow the principles of medicinal chemistry in the context of imaging-altered physiological processes. The design of a novel radiopharmaceutical has several steps similar to conventional drug discovery and some particularity. In the present work, we revisited the insights of medicinal chemistry in the current radiopharmaceutical development giving examples in oncology, neurology, and cardiology. In this regard, we overviewed the literature on radiopharmaceutical development to study overexpressed targets such as prostate-specific membrane antigen and fibroblast activation protein in cancer; β-amyloid plaques and tau protein in brain disorders; and angiotensin II type 1 receptor in cardiac disease. The work addresses concepts in the field of radiopharmacy with a special focus on the potential use of radiopharmaceuticals for nuclear imaging and theranostics. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: PET; SPECT; medicinal chemistry of radiopharmaceuticals; radiopharmaceutical development; theranostics |
| تواريخ الأحداث: | Date Created: 20230818 Latest Revision: 20230818 |
| رمز التحديث: | 20240628 |
| DOI: | 10.2174/0929867331666230818092634 |
| PMID: | 37594105 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-533X |
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| DOI: | 10.2174/0929867331666230818092634 |