دورية أكاديمية
Organoid cell fate dynamics in space and time.
| العنوان: | Organoid cell fate dynamics in space and time. |
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| المؤلفون: | Zheng X; AMOLF, Amsterdam, Netherlands., Betjes MA; AMOLF, Amsterdam, Netherlands., Ender P; AMOLF, Amsterdam, Netherlands., Goos YJ; AMOLF, Amsterdam, Netherlands., Huelsz-Prince G; AMOLF, Amsterdam, Netherlands., Clevers H; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Uppsalalaan 8, Utrecht 3584 CT, Netherlands., van Zon JS; AMOLF, Amsterdam, Netherlands. Email: j.v.zon@amolf.nl, Tans SJ; Bionanoscience Department, Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft, Netherlands.; AMOLF, Amsterdam, Netherlands. Email: s.tans@amolf.nl |
| المصدر: | Science advances [Sci Adv] 2023 Aug 18; Vol. 9 (33), pp. eadd6480. Date of Electronic Publication: 2023 Aug 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Association for the Advancement of Science, [2015]- |
| مواضيع طبية MeSH: | Organoids*, Cell Differentiation ; Cell Lineage ; Biological Transport ; Cell Movement |
| مستخلص: | Organoids are a major new tool to study tissue renewal. However, characterizing the underlying differentiation dynamics remains challenging. Here, we developed TypeTracker, which identifies cell fates by AI-enabled cell tracking and propagating end point fates back along the branched lineage trees. Cells that ultimately migrate to the villus commit to their new type early, when still deep inside the crypt, with important consequences: (i) Secretory cells commit before terminal division, with secretory fates emerging symmetrically in sister cells. (ii) Different secretory types descend from distinct stem cell lineages rather than an omnipotent secretory progenitor. (iii) The ratio between secretory and absorptive cells is strongly affected by proliferation after commitment. (iv) Spatial patterning occurs after commitment through type-dependent cell rearrangements. This "commit-then-sort" model contrasts with the conventional conveyor belt picture, where cells differentiate by moving up the crypt-villus axis and hence raises new questions about the underlying commitment and sorting mechanisms. |
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| تواريخ الأحداث: | Date Created: 20230818 Date Completed: 20230821 Latest Revision: 20231019 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10438469 |
| DOI: | 10.1126/sciadv.add6480 |
| PMID: | 37595032 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2375-2548 |
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| DOI: | 10.1126/sciadv.add6480 |