دورية أكاديمية
Egg allergy and yellow fever vaccination.
| العنوان: | Egg allergy and yellow fever vaccination. |
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| المؤلفون: | Cançado BLB; Universidade Federal de São Paulo, Divisão de Alergia, Imunologia Clínica e Reumatologia, São Paulo, SP, Brazil. Electronic address: barbaraabritto@hotmail.com., Aranda CS; Universidade Federal de São Paulo, Divisão de Alergia, Imunologia Clínica e Reumatologia, São Paulo, SP, Brazil., Mallozi MC; Universidade Federal de São Paulo, Divisão de Alergia, Imunologia Clínica e Reumatologia, São Paulo, SP, Brazil., Weckx LY; Universidade Federal de São Paulo, Divisão de Infectologia, São Paulo, SP, Brazil., Solé D; Universidade Federal de São Paulo, Divisão de Alergia, Imunologia Clínica e Reumatologia, São Paulo, SP, Brazil. |
| المصدر: | Jornal de pediatria [J Pediatr (Rio J)] 2024 Jan-Feb; Vol. 100 (1), pp. 60-66. Date of Electronic Publication: 2023 Aug 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Editora Ltda Country of Publication: Brazil NLM ID: 2985188R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4782 (Electronic) Linking ISSN: 00217557 NLM ISO Abbreviation: J Pediatr (Rio J) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Rio de Janeiro, Brazil : Elsevier Editora Ltda Original Publication: Rio de Janeiro. |
| مواضيع طبية MeSH: | Egg Hypersensitivity*/diagnosis , Yellow Fever*, Humans ; Animals ; Female ; Child ; Ovomucin ; Conalbumin ; Chickens ; Immunoglobulin E ; Vaccination/adverse effects ; Allergens |
| مستخلص: | Objective: Evaluate biomarkers capable of safely guiding Yellow fever vaccine (YFV) vaccination among individuals suspicious of hen's egg allergy, and identify factors associated with a higher risk for adverse events after immunization (AEAI). Methods: Patients underwent skin prick test (SPT) for standardized allergens: whole egg, egg white, egg yolk; YFV (1:10 dilution; Biomanguinhos-Fiocruz), and intradermal test (IDT; YFV 0.02 mL, 1:100 dilution) and positive and negative controls. Serum levels of specific IgE (sIgE) for a whole egg, egg white, egg yolk, egg albumin, ovomucoid, lysozyme, and conalbumin (ImmunoCap®; ThermoFisher®) were obtained. Patients sensitized to YFV were submitted to YFV desensitization, and those negatives received YFV (0.5mL) and remained under surveillance for at least one hour. Results: 103 patients were enrolled, 95% under 12 years old. 71% (81/103) of patients had reactions: 80% immediate, 11% mixed, and 9% delayed. There was an association between positive skin test results with YFV and the severity of the reaction (OR:7.64; 95%CI:1.61-36.32; p = 0,011). Only the presence of sIgE to ovomucoid was associated with clinical symptoms (p = 0,025). Thirty patients underwent the YFV desensitization protocol. Conclusion: There is a relationship between the positivity of the egg's components and the severity of the clinical reaction. Furthermore, the relationship between the positivity of the tests with the YFV and egg's components may show a tendency to look at ovomucoid and conalbumin, but it is not a certainty. Therefore, further studies are needed to confirm these associations, and for now, the authors still recommend using the vaccine for testing when necessary. Competing Interests: Conflicts of interest The authors declare no conflicts of interest. (Copyright © 2023 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Desensitization; Ovomucoid; Yellow fever; Yellow fever vaccine |
| المشرفين على المادة: | 37281-36-0 (Ovomucin) 1391-06-6 (Conalbumin) 37341-29-0 (Immunoglobulin E) 0 (Allergens) |
| تواريخ الأحداث: | Date Created: 20230819 Date Completed: 20240108 Latest Revision: 20240416 |
| رمز التحديث: | 20240416 |
| مُعرف محوري في PubMed: | PMC10751721 |
| DOI: | 10.1016/j.jped.2023.07.004 |
| PMID: | 37597532 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-4782 |
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| DOI: | 10.1016/j.jped.2023.07.004 |