دورية أكاديمية
أعرض في EDS

Screening of the phytochemical constituents of Teucrium polium extract and evaluation of their prophylactic role against the oxidative damage and cytotoxicity of Aflatoxin B 1 in rats.

التفاصيل البيبلوغرافية
العنوان: Screening of the phytochemical constituents of Teucrium polium extract and evaluation of their prophylactic role against the oxidative damage and cytotoxicity of Aflatoxin B 1 in rats.
المؤلفون: Boutefaha Z; Laboratory of Applied Biochemistry, Faculty of Sciences of Nature and Life, Ferhat Abbes University, Setif 1, Algeria., Diab KA; Genetics and Cytology Department, National Research Center, Dokki, Cairo, Egypt., Gheraibia S; Laboratory of Applied Biochemistry, Faculty of Sciences of Nature and Life, Ferhat Abbes University, Setif 1, Algeria., El-Nekeety AA; Food Toxicology & Contaminants Department, National Research Center, Dokki, Cairo, Egypt., Belattar N; Laboratory of Applied Biochemistry, Faculty of Sciences of Nature and Life, Ferhat Abbes University, Setif 1, Algeria., Hassan ME; Toxicology Dept., Research Institute of Medical Entomology, Giza, Egypt., Abdel-Aziem SH; Cell Biology Department, National Research Center, Dokki, Cairo, Egypt., Hassan NS; Pathology Department, National Research Center, Dokki, Cairo, Egypt., Abdel-Wahhab MA; Food Toxicology & Contaminants Department, National Research Center, Dokki, Cairo, Egypt. Electronic address: mosaad_abdelwahhab@yahoo.com.
المصدر: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2023 Sep; Vol. 233, pp. 107252. Date of Electronic Publication: 2023 Aug 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford ; New York : Pergamon Press, c1962-
مواضيع طبية MeSH: Aflatoxin B1*/toxicity , Teucrium*, Male ; Animals ; Rats ; Oxidative Stress ; Biological Assay ; Carcinogens
مستخلص: Aflatoxin B 1 (AFB 1 ) is common carcinogen causing acute and chronic hepatocyte injuries. This study aimed to determine the bioactive components of Teucrium polium methanolic extract (TPE) and to evaluate their protective role against AFB 1 -induced oxidative damage, cytotoxicity, and genotoxicity in rats. Six groups of male albino rats were treated orally for 4 weeks including the control group, the ِAFB 1 -treated group (80 μg/kg b.w.), the groups treated with low (LD) or high (HD) dose TPE (50 or 100 mg/kg b.w.), and the groups treated with AFB 1 plus TEP (LD) or TPE (HD). Blood and serum samples were collected for different assays. The GC-MS identified 34 compounds, the major compounds were pinene, germacrene D, α-cadinol, α-thujene, epi-bicyclosesquiphellandrene, and limonene. Animals that received AFB 1 showed significant changes in all indicators of oxidative stress, biochemistry, cytokines, MNPCEs, comet tail formation in bone marrow, mRNA expression of inflammatory-related genes, Nrf2, and iNOS beside histological changes in the liver. TPE at the two doses tested showed insignificant changes in all tested parameters. The extract could normalize most of these parameters and the hepatic structure in AFB 1 -treated animals in a dose-dependent fashion. therefore, we concluded that TPE supplementation is effective for protection against AFB 1 in endemic areas.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Aflatoxin B(1); Cytotoxicity; Genotoxicity; Liver; Oxidative damage; Teucrium polium
المشرفين على المادة: 9N2N2Y55MH (Aflatoxin B1)
0 (Carcinogens)
تواريخ الأحداث: Date Created: 20230819 Date Completed: 20230920 Latest Revision: 20230920
رمز التحديث: 20230920
DOI: 10.1016/j.toxicon.2023.107252
PMID: 37597789
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-3150
DOI:10.1016/j.toxicon.2023.107252