دورية أكاديمية
Single dose IV Antibiotic for Low-Energy Extremity Gunshot Wounds: A Prospective Protocol.
العنوان: | Single dose IV Antibiotic for Low-Energy Extremity Gunshot Wounds: A Prospective Protocol. |
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المؤلفون: | Nguyen MP; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., Savakus JC; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., Simske NM; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., Reich MS; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., Furdock R; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., Golob JF Jr; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., McDonald AA; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., Como JJ; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., Vallier HA; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH. |
المصدر: | Annals of surgery open : perspectives of surgical history, education, and clinical approaches [Ann Surg Open] 2022 Feb 25; Vol. 3 (1), pp. e136. Date of Electronic Publication: 2022 Feb 25 (Print Publication: 2022). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Wolters Kluwer Country of Publication: United States NLM ID: 101769928 Publication Model: eCollection Cited Medium: Internet ISSN: 2691-3593 (Electronic) Linking ISSN: 26913593 NLM ISO Abbreviation: Ann Surg Open Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Philadelphia, PA : Wolters Kluwer, [2020]- |
مستخلص: | Objective: To prospectively determine infection rate following low-energy extremity GSWs with a single dose IV antibiotic protocol. Summary Background Data: Previous work suggests that a single IV antibiotic dose, without formal surgical debridement, mitigates infection risk. Methods: Over 35 months 530 adults with low-energy GSWs to the extremities were included. Three hundred fifty-two patients (66%) had ≥30 days follow-up. Patients were administered a single dose of first-generation IV cephalosporin antibiotics, and those with operative fractures received 24-hour perioperative antibiotics. Injury characteristics, treatment, protocol adherence, and outcomes (infection) were assessed between the protocol group (single-dose antibiotics) and the non-protocol group (no antibiotics or extra doses of antibiotics). Results: Compliance with the single-dose protocol occurred in 66.8%, while 33.2% received additional antibiotics or no antibiotics. The deep infection rate requiring surgical debridement was 0.8%, while the combined rate of all infections was 11.1%. Age, sex, injury location, multiple injuries, fracture presence, and type of surgery did not affect infection rate. Adherence to the antibiotic protocol was associated with a reduction in infection risk (odds ratio = 0.39, 95% confidence interval 0.19-0.83, P = 0.01). Receipt of additional antibiotics outside of our single-dose protocol did not predict further reduction in rate of infection ( P = 0.64). Conclusions: A standardized protocol of single-dose IV antibiotic appears effective in minimizing infection after low-energy GSW to the extremities. Level of Evidence: Therapeutic Level II. (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.) |
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فهرسة مساهمة: | Keywords: GSW; antibiotics; gunshot wound; infection |
تواريخ الأحداث: | Date Created: 20230821 Latest Revision: 20230823 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10431561 |
DOI: | 10.1097/AS9.0000000000000136 |
PMID: | 37600115 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2691-3593 |
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DOI: | 10.1097/AS9.0000000000000136 |