دورية أكاديمية
Single dose IV Antibiotic for Low-Energy Extremity Gunshot Wounds: A Prospective Protocol.
| العنوان: | Single dose IV Antibiotic for Low-Energy Extremity Gunshot Wounds: A Prospective Protocol. |
|---|---|
| المؤلفون: | Nguyen MP; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., Savakus JC; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., Simske NM; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., Reich MS; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., Furdock R; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., Golob JF Jr; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., McDonald AA; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., Como JJ; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH., Vallier HA; From the MetroHealth System, affiliated with Case Western Reserve University, Cleveland, OH. |
| المصدر: | Annals of surgery open : perspectives of surgical history, education, and clinical approaches [Ann Surg Open] 2022 Feb 25; Vol. 3 (1), pp. e136. Date of Electronic Publication: 2022 Feb 25 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Country of Publication: United States NLM ID: 101769928 Publication Model: eCollection Cited Medium: Internet ISSN: 2691-3593 (Electronic) Linking ISSN: 26913593 NLM ISO Abbreviation: Ann Surg Open Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : Wolters Kluwer, [2020]- |
| مستخلص: | Objective: To prospectively determine infection rate following low-energy extremity GSWs with a single dose IV antibiotic protocol. Summary Background Data: Previous work suggests that a single IV antibiotic dose, without formal surgical debridement, mitigates infection risk. Methods: Over 35 months 530 adults with low-energy GSWs to the extremities were included. Three hundred fifty-two patients (66%) had ≥30 days follow-up. Patients were administered a single dose of first-generation IV cephalosporin antibiotics, and those with operative fractures received 24-hour perioperative antibiotics. Injury characteristics, treatment, protocol adherence, and outcomes (infection) were assessed between the protocol group (single-dose antibiotics) and the non-protocol group (no antibiotics or extra doses of antibiotics). Results: Compliance with the single-dose protocol occurred in 66.8%, while 33.2% received additional antibiotics or no antibiotics. The deep infection rate requiring surgical debridement was 0.8%, while the combined rate of all infections was 11.1%. Age, sex, injury location, multiple injuries, fracture presence, and type of surgery did not affect infection rate. Adherence to the antibiotic protocol was associated with a reduction in infection risk (odds ratio = 0.39, 95% confidence interval 0.19-0.83, P = 0.01). Receipt of additional antibiotics outside of our single-dose protocol did not predict further reduction in rate of infection ( P = 0.64). Conclusions: A standardized protocol of single-dose IV antibiotic appears effective in minimizing infection after low-energy GSW to the extremities. Level of Evidence: Therapeutic Level II. (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.) |
| References: | J Orthop Trauma. 1989;3(1):6-10. (PMID: 2709206) Arch Orthop Trauma Surg. 2016 Jun;136(6):751-4. (PMID: 27043840) Orthopedics. 2001 Oct;24(10):951-4. (PMID: 11688773) Clin Orthop Relat Res. 1989 Jun;(243):36-40. (PMID: 2721073) J Bone Joint Surg Am. 1996 Aug;78(8):1167-71. (PMID: 8753708) Injury. 2018 Mar;49(3):570-574. (PMID: 29396308) JAMA. 1999 Aug 4;282(5):447-54. (PMID: 10442660) J Am Acad Orthop Surg. 2000 Jan-Feb;8(1):21-36. (PMID: 10666650) Orthopedics. 1987 Dec;10(12):1781-8. (PMID: 3324085) J Orthop Trauma. 2017 Jun;31(6):326-329. (PMID: 28240620) J Orthop Trauma. 2015 Jan;29(1):1-6. (PMID: 25526095) J Orthop Trauma. 2017 Jun;31(6):330-333. (PMID: 28230571) J Bone Joint Surg Am. 1974 Apr;56(3):532-41. (PMID: 4150798) J Bone Joint Surg Am. 1976 Jun;58(4):453-8. (PMID: 773941) J Bone Joint Surg Am. 2009 Apr;91(4):980-97. (PMID: 19339586) Prev Med. 2015 Oct;79:5-14. (PMID: 26116133) J Orthop Trauma. 2021 Feb 1;35(2):e61-e63. (PMID: 32569067) Clin Orthop Relat Res. 2013 Dec;471(12):3937-44. (PMID: 23463285) |
| فهرسة مساهمة: | Keywords: GSW; antibiotics; gunshot wound; infection |
| تواريخ الأحداث: | Date Created: 20230821 Latest Revision: 20230823 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10431561 |
| DOI: | 10.1097/AS9.0000000000000136 |
| PMID: | 37600115 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!