دورية أكاديمية
Use of PET/CT to detect myocardial inflammation and the risk of malignant arrhythmia in chronic Chagas disease.
| العنوان: | Use of PET/CT to detect myocardial inflammation and the risk of malignant arrhythmia in chronic Chagas disease. |
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| المؤلفون: | de Oliveira RS; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.; Internal Medicine Department, Rio de Janeiro Federal State University, Rio de Janeiro, Brazil., Moll-Bernardes R; D'Or Institute for Research and Education, Rio de Janeiro, Brazil., de Brito AX; D'Or Institute for Research and Education, Rio de Janeiro, Brazil., Pinheiro MVT; D'Or Institute for Research and Education, Rio de Janeiro, Brazil., de Almeida SA; D'Or Institute for Research and Education, Rio de Janeiro, Brazil., da Silva Gomes NL; Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., de Oliveira Terzi FV; D'Or Institute for Research and Education, Rio de Janeiro, Brazil., Moreira OC; Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Xavier SS; Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Rosado-de-Castro PH; D'Or Institute for Research and Education, Rio de Janeiro, Brazil., de Sousa AS; D'Or Institute for Research and Education, Rio de Janeiro, Brazil. andrea.silvestre@fiocruz.br.; Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. andrea.silvestre@fiocruz.br. |
| المصدر: | Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2023 Dec; Vol. 30 (6), pp. 2702-2711. Date of Electronic Publication: 2023 Aug 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc. on behalf of American Society of Nuclear Cardiology Country of Publication: United States NLM ID: 9423534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6551 (Electronic) Linking ISSN: 10713581 NLM ISO Abbreviation: J Nucl Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : New York : Elsevier Inc. on behalf of American Society of Nuclear Cardiology Original Publication: St. Louis, MO : Mosby-Year Book, Inc., c1994- |
| مواضيع طبية MeSH: | Myocarditis*/diagnostic imaging , Heart Diseases* , Chagas Disease*/complications , Chagas Disease*/diagnostic imaging, Humans ; Positron Emission Tomography Computed Tomography ; Fluorodeoxyglucose F18 ; Positron-Emission Tomography/methods ; Gallium Radioisotopes ; Cross-Sectional Studies ; Parasitemia ; Prospective Studies ; Arrhythmias, Cardiac/diagnostic imaging ; Inflammation/diagnostic imaging ; Death, Sudden, Cardiac |
| مستخلص: | Background: Chagas heart disease (CHD) is characterized by progressive myocardial inflammation associated with myocardial fibrosis and segmental abnormalities that may lead to malignant ventricular arrhythmia and sudden cardiac death. This arrhythmia might be related to the persistence of parasitemia or inflammation in the myocardium in late-stage CHD. Positron emission tomography/computed tomography (PET/CT) has been used to detect myocardial inflammation in non-ischemic cardiomyopathies, such as sarcoidosis, and might be useful for risk prediction in patients with CHD. Methods and Results: Twenty-four outpatients with chronic CHD were enrolled in this prospective cross-sectional study between May 2019 and March 2022. The patients were divided into two groups: those with sustained ventricular tachycardia and/or aborted sudden cardiac death who required implantable cardioverter-defibrillators, and those with the same stages of CHD and no complex ventricular arrhythmia. Patients underwent 18 F-fluorodeoxyglucose ( 18 F-FDG) and 68 Ga-DOTATOC PET/CT, and blood samples were collected for qualitative parasite assessment by polymerase chain reaction. Although similar proportions of patients with and without complex ventricular arrhythmia showed 18 F-FDG and 68 Ga-DOTATOC uptake, 68 Ga-DOTATOC corrected SUV Conclusion: 18 F-FDG and 68 Ga-DOTATOC uptake on PET/CT may be useful for the detection of myocardial inflammation in patients with Chagas cardiomyopathy, and 68 Ga-DOTATOC uptake may be associated with the presence of malignant arrhythmia, with potential therapeutic implications. (© 2023. The Author(s) under exclusive licence to American Society of Nuclear Cardiology.) |
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| فهرسة مساهمة: | Keywords: Cardiomyopathy; PET; inflammation; molecular imaging; molecular imaging agents |
| المشرفين على المادة: | 0Z5B2CJX4D (Fluorodeoxyglucose F18) 0 (Gallium Radioisotopes) |
| تواريخ الأحداث: | Date Created: 20230821 Date Completed: 20231128 Latest Revision: 20240130 |
| رمز التحديث: | 20240130 |
| DOI: | 10.1007/s12350-023-03350-z |
| PMID: | 37605061 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-6551 |
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| DOI: | 10.1007/s12350-023-03350-z |