دورية أكاديمية
Pharmaco-EEG analysis of ligands varying in selectivity for α1 subunit-containing GABA A receptors during the active phase in rats.
| العنوان: | Pharmaco-EEG analysis of ligands varying in selectivity for α1 subunit-containing GABA |
|---|---|
| المؤلفون: | Reeves-Darby JA; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.; Graduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Berro LF; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.; Graduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, 39216, USA.; Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Platt DM; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.; Graduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, 39216, USA.; Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Rüedi-Bettschen D; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.; Graduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, 39216, USA.; Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Shaffery JP; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA., Rowlett JK; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA. jrowlett@umc.edu.; Graduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, 39216, USA. jrowlett@umc.edu.; Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS, 39216, USA. jrowlett@umc.edu. |
| المصدر: | Psychopharmacology [Psychopharmacology (Berl)] 2023 Dec; Vol. 240 (12), pp. 2561-2571. Date of Electronic Publication: 2023 Aug 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin, New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Benzodiazepines*/pharmacology , Receptors, GABA-A*/physiology, Rats ; Male ; Animals ; Zolpidem ; Rats, Sprague-Dawley ; Electroencephalography ; gamma-Aminobutyric Acid |
| مستخلص: | Rationale: Benzodiazepines are known to evoke changes in cortical electrophysiological activity that can be correlated with action at distinct γ-aminobutyric acid type A (GABA Objectives: We used electroencephalography (EEG) paired with electromyography (EMG) to evaluate the role of α1 subunit-containing GABA Methods: Male Sprague-Dawley rats (N = 4/drug) were surgically instrumented with EEG/EMG electrodes. The rats were injected i.p. with zolpidem, an α1GABA Results: All ligands evaluated induced changes in sleep-wake states during the active phase consistent with an increase in slow-wave sleep (SWS). The degree of SWS increase appeared to be related to the magnitude of delta power band changes induced by the ligands, with the strongest effects engendered by the α1GABA Conclusions: Overall, these findings support the establishment of pharmaco-EEG "signatures" for identifying subtype-selective GABA (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
| References: | Atack JR, Hallett DJ, Tye S, Wafford KA, Ryan C, Sanabria-Bohórquez SM, Eng WS, Gibson RE, Burns HD, Dawson GR, Carling RW, Street LJ, Pike A, De Lepeleire I, Van Laere K, Bormans G, de Hoon JN, Van Hecken A, McKernan RM et al (2011) Preclinical and clinical pharmacology of TPA023B, a GABA Behlke LM, Foster RA, Liu J, Benke D, Benham RS, Nathanson AJ, Yee BK, Zeilhofer HU, Engin E, Rudolph U (2016) A pharmacogenetic “restriction-of-function” approach reveals evidence for anxiolytic-like actions mediated by α5-containing GABA Berro LF, Overton JS, Reeves-Darby JA, Rowlett JK (2021) Alprazolam-induced EEG spectral power changes in rhesus monkeys: a translational model for the evaluation of the behavioral effects of benzodiazepines. Psychopharmacology (Berl) 238:1373–1386. (PMID: 10.1007/s00213-021-05793-z33594504) Berro LF, Rüedi-Bettschen D, Cook JE, Golani LK, Li G, Jahan R, Rashid F, Cook JM, Rowlett JK, Platt DM (2019) GABA Buchsbaum MS, Hazlett E, Sicotte N, Stein M, Wu J, Zetin M (1985) Topographic EEG changes with benzodiazepine administration in generalized anxiety disorder. Biol Psychiatry 20:832–842. (PMID: 10.1016/0006-3223(85)90208-22862924) Cerne R, Lippa A, Poe MM, Smith JL, Jin X, Ping X, Golani LK, Cook JM, Witkin JM (2022) GABAkines—advances in the discovery, development, and commercialization of positive allosteric modulators of GABA Chen X, Jacobs G, de Kam M, Jaeger J, Lappalainen J, Maruff P, Smith MA, Cross AJ, Cohen A, van Gerven J (2014) The central nervous system effects of the partial GABA-Aα2,3 -selective receptor modulator AZD7325 in comparison with lorazepam in healthy males. Br J Clin Pharmacol 78:1298–1314. (PMID: 10.1111/bcp.12413248027224256620) Christian EP, Snyder DH, Song W, Gurley DA, Smolka J, Maier DL, Ding M, Gharahdaghi F, Liu XF, Chopra M, Ribadeneira M, Chapdelaine MJ, Dudley A, Arriza JL, Maciag C, Quirk MC, Doherty JJ (2015) E EG-β/γ spectral power elevation in rat: a translatable biomarker elicited by GABA Coenen AM, van Luijtelaar EL (1991) Pharmacological dissociation of EEG and behavior: a basic problem in sleep-wake classification. Sleep 14:464–465. (PMID: 1759100) Davis CJ, Clinton JM, Jewett KA, Zielinski MR, Krueger JM (2011) Delta wave power: an independent sleep phenotype or epiphenomenon? J Clin Sleep Med 15(5 Suppl):S16–S18. Dijk DJ, Beersma DG, Daan S, van den Hoofdakker RH (1989) Effects of seganserin, a 5-HT2 antagonist, and temazepam on human sleep stages and EEG power spectra. Eur J Pharmacol 171:207–218. (PMID: 10.1016/0014-2999(89)90109-X2576000) Drinkenburg WH, Ahnaou A, Ruigt GS (2015a) Pharmaco-EEG studies in animals: a history-based introduction to contemporary translational applications. Neuropsychobiology 72:139–150. (PMID: 10.1159/00044317526901675) Drinkenburg WHIM, Ruigt GSF, Ahnaou A (2015b) Pharmaco-EEG studies in animals: an overview of contemporary translational applications. Neuropsychobiology 72:151–164. (PMID: 10.1159/000442210) Duke AN, Meng Z, Platt DM, Atack JR, Dawson GR, Reynolds DS, Tiruveedhula VVNPB, Li G, Stephen MR, Sieghart W, Cook JM, Rowlett JK (2018) Evidence that sedative effects of benzodiazepines involve unexpected GABA Engin E, Benham RS, Rudolph U (2018) An emerging circuit pharmacology of GABA Ghit A, Assal D, Al-Shami AS, Hussein DEE (2021) GABA Gilles C, Luthringer R (2007) Pharmacological models in healthy volunteers: their use in the clinical development of psychotropic drugs. J Psychopharmacol (Oxf) 21:272–282. (PMID: 10.1177/0269881107077733) Jongsma ML, van Rijn CM, van Egmond J, van Schaijk WJ, Sambeth A, Coenen AM (2000) The influence of diazepam on the electroencephalogram-evoked potential interrelation in rats. Neurosci Lett 293:83–86. (PMID: 10.1016/S0304-3940(00)01496-811027839) Knoflach F, Bertrand D (2021) Pharmacological modulation of GABA Kopp C, Rudolph U, Keist R, Tobler I (2003) Diazepam-induced changes on sleep and the EEG spectrum in mice: role of α3-GABA Kopp C, Rudolph U, Löwe K, Tobler I (2004) Modulation of rhythmic brain activity by diazepam: GABA Leiser SC, Dunlop J, Bowlby MR, Devilbliss DM (2011) Aligning strategies for using EEG as a surrogate biomarker: a review of preclinical and clinical research. Biochem Pharmacol 81:1408–1421. (PMID: 10.1016/j.bcp.2010.10.00220937262) Liu J, Singh H, White PF (1996) Electroencephalogram bispectral analysis predicts the depth of midazolam-induced sedation. Anesthesiology 84:64–69. (PMID: 10.1097/00000542-199601000-000078572355) McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, Farrar S, Myers J, Cook G, Ferris P, Garrett L, Bristow L, Marshall G, Macaulay A, Brown N, Howell O, Moore KW, Carling RW, Street LJ et al (2000) Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. Nat Neurosci 3:587–592. (PMID: 10.1038/7576110816315) Meng Z, Berro LF, Sawyer EK, Rüedi-Bettschen D, Cook JE, Li G, Platt DM, Cook JM, Rowlett JK (2020) Evaluation of the anti-conflict, reinforcing, and sedative effects of YT-III-31, a ligand functionally selective for α3 subunit-containing GABA Nickolls SA, Gurrell R, van Amerongen G, Kammonen J, Cao L, Brown AR, Stead C, Mead A, Watson C, Hsu C, Owen RM, Pike A, Fish RL, Chen L, Qiu R, Morris ED, Feng G, Whitlock M, Gorman D et al (2018) Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABA Rowlett JK, Platt DM, Lelas S, Atack JR, Dawson GR (2005) Different GABA Saletu B, Anderer P, Saletu-Zyhlarz GM (2006) EEG topography and tomography (LORETA) in the classification and evaluation of the pharmacodynamics of psychotropic drugs. Clin EEG Neurosci 37:66–80. (PMID: 10.1177/15500594060370020516733939) Tobler I, Kopp C, Deboer T, Rudolph W (2001) Diazepam-induced changes in sleep: role of the α1GABA van Lier H, Drinkenburg WH, van Eeten YJ, Coenen AM (2004) Effects of diazepam and zolpidem on EEG beta frequencies are behavior-specific in rats. Neuropharmacology 47:163–174. (PMID: 10.1016/j.neuropharm.2004.03.01715223295) Versavel M, Leonard JP, Herrmann WM (1995) Standard operating procedure for the registration and computer-supported evaluation of pharmaco-EEG data. 'EEG in Phase I' of the Collegium Internationale Psychiatriae Scalarum (CIPS). Neuropsychobiology 32:166–170. (PMID: 10.1159/0001192308544975) Visser SAG, Wolters FLC, Gubbens-Stibbe JM, Tukker E, Van der Graaf PH, Peletier LA, Danhof M (2003) Mechanism-based PK/PD modelling of the EEG effects of GABA |
| معلومات مُعتمدة: | R00 DA049886 United States DA NIDA NIH HHS; R01 AA029023 United States AA NIAAA NIH HHS; R21 DA052801 United States DA NIDA NIH HHS; K99 DA049886 United States DA NIDA NIH HHS; P20 GM121334 United States GM NIGMS NIH HHS; R01 DA043204 United States DA NIDA NIH HHS; R01 DA011792 United States DA NIDA NIH HHS; F31 AA029306 United States AA NIAAA NIH HHS |
| فهرسة مساهمة: | Keywords: Benzodiazepines; EEG; Rats; Slow wave sleep; Spectral power |
| المشرفين على المادة: | 7K383OQI23 (Zolpidem) 8CZO0970G3 (L 838,417) 12794-10-4 (Benzodiazepines) 0 (Receptors, GABA-A) 56-12-2 (gamma-Aminobutyric Acid) |
| تواريخ الأحداث: | Date Created: 20230823 Date Completed: 20231113 Latest Revision: 20240307 |
| رمز التحديث: | 20240308 |
| مُعرف محوري في PubMed: | PMC10795493 |
| DOI: | 10.1007/s00213-023-06450-3 |
| PMID: | 37608193 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-2072 |
|---|---|
| DOI: | 10.1007/s00213-023-06450-3 |