التفاصيل البيبلوغرافية
| العنوان: |
Chikungunya virus antepartum transmission and abnormal infant outcomes in Nigeria. |
| المؤلفون: |
Sagay AS, Hsieh SC, Dai YC, Chang CA, Ogwuche J, Ige OO, Kahansim ML, Chaplin B, Imade G, Elujoba M, Paul M, Hamel DJ, Furuya H, Khoury R, Boaventura VS, de Moraes L, Kanki PJ, Wang WK |
| المصدر: |
MedRxiv : the preprint server for health sciences [medRxiv] 2023 Aug 09. Date of Electronic Publication: 2023 Aug 09. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
Chikungunya virus (CHIKV) has become a global public health concern since the reemergence of the Indian Ocean lineage and expansion of the Asian genotype. CHIKV infection causes acute febrile illness, rash, and arthralgia and during pregnancy may affect both mothers and infants. The mother-to-child transmission (MTCT) of CHIKV in Africa remains understudied. We screened 1006 pregnant women at two clinics in Nigeria between 2019 and 2022 and investigated the prevalence and MTCT of CHIKV. Of the 1006, 119 tested positive for CHIKV IgM, of which 36 underwent detailed laboratory tests. While none of the IgM reactive samples were RT-PCR positive, 14 symptomatic pregnant women were confirmed by CHIKV neutralization test. Twelve babies were followed with 8 normal and 4 abnormal outcomes, including stillbirth, cleft lip/palate with microcephaly, preterm delivery, polydactyly with sepsis and jaundice. CHIKV IgM testing identified 3 antepartum transmissions, further studies will determine its impact in antepartum infection. |
| التعليقات: |
Update in: Int J Infect Dis. 2023 Dec 4;:. (PMID: 38056689) |
| تواريخ الأحداث: |
Date Created: 20230823 Latest Revision: 20231219 |
| رمز التحديث: |
20231220 |
| مُعرف محوري في PubMed: |
PMC10441498 |
| DOI: |
10.1101/2023.08.05.23293675 |
| PMID: |
37609297 |
| قاعدة البيانات: |
MEDLINE |
