دورية أكاديمية
أعرض في EDS

Trends among platelet function, arterial calcium, and vascular function measures.

التفاصيل البيبلوغرافية
العنوان: Trends among platelet function, arterial calcium, and vascular function measures.
المؤلفون: Cunha J; National Heart, Lung and Blood Institute's the Framingham Heart Study, Boston University and National Heart, Framingham, MA, USA.; National Heart, Lung and Blood Institute, Population Sciences Branch, Framingham, MA, USA., Chan MV; National Heart, Lung and Blood Institute's the Framingham Heart Study, Boston University and National Heart, Framingham, MA, USA.; National Heart, Lung and Blood Institute, Population Sciences Branch, Framingham, MA, USA., Nkambule BB; National Heart, Lung and Blood Institute's the Framingham Heart Study, Boston University and National Heart, Framingham, MA, USA.; National Heart, Lung and Blood Institute, Population Sciences Branch, Framingham, MA, USA., Thibord F; National Heart, Lung and Blood Institute's the Framingham Heart Study, Boston University and National Heart, Framingham, MA, USA.; National Heart, Lung and Blood Institute, Population Sciences Branch, Framingham, MA, USA., Lachapelle A; National Heart, Lung and Blood Institute's the Framingham Heart Study, Boston University and National Heart, Framingham, MA, USA.; National Heart, Lung and Blood Institute, Population Sciences Branch, Framingham, MA, USA., Pashek RE; National Heart, Lung and Blood Institute's the Framingham Heart Study, Boston University and National Heart, Framingham, MA, USA.; National Heart, Lung and Blood Institute, Population Sciences Branch, Framingham, MA, USA., Vasan RS; National Heart, Lung and Blood Institute's the Framingham Heart Study, Boston University and National Heart, Framingham, MA, USA.; Cardiology and Preventive Medicine Sections, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.; Evans Center for Interdisciplinary Biomedical Research, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; Whitaker Cardiovascular Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; Schools of Public Health and Medicine, Departments of Population Health and Medicine, University of Texas Health Sciences Center, San Antonio, TX, USA., Rong J; National Heart, Lung and Blood Institute's the Framingham Heart Study, Boston University and National Heart, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Benjamin EJ; National Heart, Lung and Blood Institute's the Framingham Heart Study, Boston University and National Heart, Framingham, MA, USA.; Cardiology and Preventive Medicine Sections, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.; Evans Center for Interdisciplinary Biomedical Research, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; Whitaker Cardiovascular Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., Hamburg NM; Whitaker Cardiovascular Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., Chen MH; National Heart, Lung and Blood Institute's the Framingham Heart Study, Boston University and National Heart, Framingham, MA, USA.; National Heart, Lung and Blood Institute, Population Sciences Branch, Framingham, MA, USA., Mitchell GF; Cardiovascular Engineering, Inc, Norwood, MA, USA., Johnson AD; National Heart, Lung and Blood Institute's the Framingham Heart Study, Boston University and National Heart, Framingham, MA, USA.; National Heart, Lung and Blood Institute, Population Sciences Branch, Framingham, MA, USA.
المصدر: Platelets [Platelets] 2023 Dec; Vol. 34 (1), pp. 2238835.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9208117 Publication Model: Print Cited Medium: Internet ISSN: 1369-1635 (Electronic) Linking ISSN: 09537104 NLM ISO Abbreviation: Platelets Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Informa Healthcare
Original Publication: Edinburgh ; New York : Churchill Livingstone, c1990-
مواضيع طبية MeSH: Calcium* , Atherosclerosis*, Female ; Male ; Humans ; Pulse Wave Analysis ; Blood Pressure ; Platelet Activation
مستخلص: Arterial tonometry and vascular calcification measures are useful in cardiovascular disease (CVD) risk assessment. Prior studies found associations between tonometry measures, arterial calcium, and CVD risk. Activated platelets release angiopoietin-1 and other factors, which may connect vascular structure and platelet function. We analyzed arterial tonometry, platelet function, aortic, thoracic and coronary calcium, and thoracic and abdominal aorta diameters measured in the Framingham Heart Study Gen3/NOS/OMNI-2 cohorts ( n  = 3,429, 53.7% women, mean age 54.4 years ±9.3). Platelet reactivity in whole blood or platelet-rich plasma was assessed using 5 assays and 7 agonists. We analyzed linear mixed effects models with platelet reactivity phenotypes as outcomes, adjusting for CVD risk factors and family structure. Higher arterial calcium trended with higher platelet reactivity, whereas larger aortic diameters trended with lower platelet reactivity. Characteristic impedance (Zc) and central pulse pressure positively trended with various platelet traits, while pulse wave velocity and Zc negatively trended with collagen, ADP, and epinephrine traits. All results did not pass a stringent multiple test correction threshold ( p  < 2.22e-04). The diameter trends were consistent with lower shear environments invoking less platelet reactivity. The vessel calcium trends were consistent with subclinical atherosclerosis and platelet activation being inter-related.
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معلومات مُعتمدة: R01 HL092577 United States HL NHLBI NIH HHS; HHSN268201500001I United States HL NHLBI NIH HHS; R01 HL143227 United States HL NHLBI NIH HHS; R01 HL131532 United States HL NHLBI NIH HHS; R01 HL093328 United States HL NHLBI NIH HHS; 75N92019D00031 United States HL NHLBI NIH HHS; R01 HL142983 United States HL NHLBI NIH HHS; R01 HL126136 United States HL NHLBI NIH HHS; HHSN268201500001C United States HL NHLBI NIH HHS; R01 HL107385 United States HL NHLBI NIH HHS; N01HC25195 United States HL NHLBI NIH HHS; Z99 HL999999 United States ImNIH Intramural NIH HHS
فهرسة مساهمة: Keywords: Aortic diameter; Platelet; arterial tonometry; epidemiology; vascular calcification
Local Abstract: [plain-language-summary] What is the context? Prior research has reported that measures of vascular system-influencing proteins such as angiopoietin-2, arterial calcium plaque formation, and arterial stiffness assessed by tonometry are associated with CVD risk.Since activated platelets produce and release vascular proteins like angiopoietin when activated, and microparticles that interact with endothelium, release of the foregoing mediators could provide one way in which vascular structure and platelet function influence each other.To our knowledge, no prior studies have directly investigated associations between these measures in a large sample. This investigation relates platelet function to arterial tonometry, aortic and arterial diameter, and arterial calcium measures in the Framingham Heart Study (FHS) Gen3/NOS/OMNI-2 cohorts ( n  = 3,429). What’s new? Generally, higher arterial calcium measures trended with higher platelet reactivity, whereas larger aortic diameters trended with lower platelet reactivity.Arterial tonometry measures had positive and negative trends with platelet functions, including platelet measures with opposite relations to negative-inverse carotid-femoral pulse wave velocity (niCFPWV) and characteristic impedance (Zc). All tonometry, calcium, and diameter results did not reach a more stringent multiple testing threshold ( p  < 2.22e-04). What’s the impact? The aortic diameter trends are consistent with lower shear stress invoking less platelet reactivity.The vessel calcium trends are consistent with increased vascular calcium buildup that could provoke platelet activation, thereby contributing to increased blood clot risk. Conversely, increased platelet activation could contribute to increased inflammation and thrombosis, leading to calcification in the arterial wall.
المشرفين على المادة: SY7Q814VUP (Calcium)
تواريخ الأحداث: Date Created: 20230823 Date Completed: 20230824 Latest Revision: 20240617
رمز التحديث: 20240617
مُعرف محوري في PubMed: PMC10947606
DOI: 10.1080/09537104.2023.2238835
PMID: 37609998
قاعدة البيانات: MEDLINE
الوصف
تدمد:1369-1635
DOI:10.1080/09537104.2023.2238835