دورية أكاديمية
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Structural and immunohistochemical characterization of pancreas of Molly fish (Poecilia sphenops), with a special reference to its immune role.

التفاصيل البيبلوغرافية
العنوان: Structural and immunohistochemical characterization of pancreas of Molly fish (Poecilia sphenops), with a special reference to its immune role.
المؤلفون: Hussein MM; Department of Cell and Tissues, Faculty of Veterinary Medicine, Assuit University, Assiut, Egypt., Sayed RKA; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Sohag University, Sohag, Egypt., Mokhtar DM; Department of Cell and Tissues, Faculty of Veterinary Medicine, Assuit University, Assiut, Egypt.; Department of Histology and Anatomy, School of Veterinary Medicine, Badr University in Assuit, Assiut, Egypt.
المصدر: Microscopy research and technique [Microsc Res Tech] 2023 Dec; Vol. 86 (12), pp. 1667-1680. Date of Electronic Publication: 2023 Aug 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 9203012 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0029 (Electronic) Linking ISSN: 1059910X NLM ISO Abbreviation: Microsc Res Tech Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Wiley-Liss, c1992-
مواضيع طبية MeSH: Poecilia*, Animals ; NF-kappa B/metabolism ; NF-E2-Related Factor 2/metabolism ; Pancreas ; Transforming Growth Factor beta/metabolism
مستخلص: Recently, teleost species have been considered important model systems for investigating different research areas including immunologic one. The available literature provides poor data about the localization and the structure of pancreas in Molly fish. Moreover, little attention has been paid to the immunologic role of pancreatic tissue of teleost, particularly Molly fish; therefore, this study aimed to highlights the description of pancreatic tissue in Molly fish using light- and electron- microscopy, focusing on the role of pancreatic immune cells and pancreatic acinar cells in immune responses. Microscopic analysis revealed that the pancreas of Molly fish was composed of intrahepatic, disseminated and compact parts. Exocrine pancreatic tissue was diffusely extended within the hepatic tissue forming hepatopancreas. The disseminated pancreas appeared as several irregular nodules of pancreatic tissue localized within the mesenteric adipose tissue. The compact pancreas appeared as an oval shaped body embedded within the mesenteric adipose tissue between the spleen and the intestinal loops. Several telocytes and melanomacrophages were detected within the disseminated pancreatic nodules. Moreover, dendritic cells were found in a close association to the exocrine pancreatic acini. The pancreatic acinar cells showed strong immunoreactivity to APG5, TGF-β, IL-1β, NF-κB, Nrf2, and SOX9 in both hepatopancreas and disseminated pancreas of Molly fish. S100 protein revealed a strong expression in the exocrine pancreatic acinar cells of disseminated pancreas and also in the endocrine cells of the compact pancreas. In conclusion, findings of this study suggest the potential role of the pancreas of the Molly fish in cell proliferation and differentiation, proinflammatory cytokines stimulation, and regulation of both innate and adaptive immunity. RESEARCH HIGHLIGHTS: Telocytes and melanomacrophages were detected in the disseminated pancreatic nodules of the Molly fish. In Molly fish, dendritic cells were found in a close association to the exocrine pancreatic acini. Strong immunoreactivity of the pancreatic acinar cells of the Molly fish to APG5, TGF-β, IL-1β, NF-κB, Nrf2, SOX9, and S100.
(© 2023 Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: Brockmann bodies; IL-1β; SOX9; lymphocytes; pancreatic acini
المشرفين على المادة: 0 (NF-kappa B)
0 (NF-E2-Related Factor 2)
0 (Transforming Growth Factor beta)
تواريخ الأحداث: Date Created: 20230823 Date Completed: 20240214 Latest Revision: 20240214
رمز التحديث: 20240214
DOI: 10.1002/jemt.24407
PMID: 37610072
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-0029
DOI:10.1002/jemt.24407