دورية أكاديمية
أعرض في EDS

Trimethylamine N-Oxide and White Matter Hyperintensity Volume Among Patients With Acute Ischemic Stroke.

التفاصيل البيبلوغرافية
العنوان: Trimethylamine N-Oxide and White Matter Hyperintensity Volume Among Patients With Acute Ischemic Stroke.
المؤلفون: Kijpaisalratana N; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston.; Department of Neurology, Massachusetts General Hospital, Boston.; Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Ament Z; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston.; Department of Neurology, Massachusetts General Hospital, Boston., Bevers MB; Divisions of Stroke, Cerebrovascular and Critical Care Neurology, Brigham and Women's Hospital, Boston, Massachusetts., Bhave VM; Harvard Medical School, Boston, Massachusetts., Garcia Guarniz AL; Department of Neurology, Massachusetts General Hospital, Boston., Couch CA; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham., Irvin MR; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham., Kimberly WT; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston.; Department of Neurology, Massachusetts General Hospital, Boston.; Harvard Medical School, Boston, Massachusetts.
المصدر: JAMA network open [JAMA Netw Open] 2023 Aug 01; Vol. 6 (8), pp. e2330446. Date of Electronic Publication: 2023 Aug 01.
نوع المنشور: Observational Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Chicago, IL : American Medical Association, [2018]-
مواضيع طبية MeSH: Ischemic Stroke*/diagnostic imaging , Stroke, Lacunar* , White Matter*/diagnostic imaging , Stroke*/diagnostic imaging , Stroke*/epidemiology , Cerebral Small Vessel Diseases*, Humans ; Female ; Male ; Aged ; Betaine ; Cross-Sectional Studies ; Carnitine ; Choline
مستخلص: Importance: Although increasing evidence suggests that trimethylamine N-oxide (TMAO) is associated with atherosclerosis, little is known about whether TMAO and its related metabolites (ie, choline, betaine, and carnitine) are associated with small vessel disease.
Objective: To evaluate the association between TMAO and its related metabolites with features of cerebral small vessel disease, including white matter hyperintensity volume (WMHV) and acute lacunar infarction.
Design, Setting, and Participants: This cross-sectional study included patients enrolled in the Specialized Programs of Translational Research in Acute Stroke biorepository. The registry included 522 patients with acute ischemic stroke who were 18 years or older who presented at the Massachusetts General Hospital or Brigham and Women's Hospital within 9 hours after onset between January 2007 and April 2010. The analyses in this study were conducted between November 2022 and April 2023.
Exposures: Plasma TMAO, choline, betaine, and carnitine were measured by liquid chromatography-tandem mass spectrometry.
Main Outcomes and Measures: WMHV was quantified by a semiautomated approach using signal intensity threshold with subsequent manual editing. Ischemic stroke subtype was classified using the Causative Classification System.
Results: Among 351 patients included in this study, the mean (SD) age was 69 (15) years; 209 patients (59.5%) were male and had a median (IQR) admission National Institute of Health Stroke Scale of 6 (3-13). The magnetic resonance imaging subgroup consisted of 291 patients with a mean (SD) age of 67 (15) years. Among these, the median (IQR) WMHV was 3.2 (1.31-8.4) cm3. TMAO was associated with WMHV after adjustment for age and sex (β, 0.15; 95% CI, 0.01-0.29; P < .001). TMAO remained significant in a multivariate analysis adjusted for age, sex, hypertension, diabetes, and smoking (β, 0.14; 95% CI, 0-0.29; P = .05). TMAO was associated with lacunar stroke but not other ischemic stroke subtypes in a model adjusted for age, sex, hypertension, diabetes, and smoking (OR, 1.67; 95% CI, 1.05-2.66; P = .03).
Conclusions and Relevance: In this observational study, TMAO was associated with cerebral small vessel disease determined by WMHV and acute lacunar infarction. The association was independent of traditional vascular risk factors.
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معلومات مُعتمدة: K23 NS112474 United States NS NINDS NIH HHS; T32 HL007457 United States HL NHLBI NIH HHS
المشرفين على المادة: FLD0K1SJ1A (trimethyloxamine)
3SCV180C9W (Betaine)
S7UI8SM58A (Carnitine)
N91BDP6H0X (Choline)
تواريخ الأحداث: Date Created: 20230823 Date Completed: 20230824 Latest Revision: 20240314
رمز التحديث: 20240314
مُعرف محوري في PubMed: PMC10448304
DOI: 10.1001/jamanetworkopen.2023.30446
PMID: 37610752
قاعدة البيانات: MEDLINE
الوصف
تدمد:2574-3805
DOI:10.1001/jamanetworkopen.2023.30446