دورية أكاديمية
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Determination of drug-related problems among type 2 diabetes outpatients in a hospital in Vietnam: A cross-sectional study.

التفاصيل البيبلوغرافية
العنوان: Determination of drug-related problems among type 2 diabetes outpatients in a hospital in Vietnam: A cross-sectional study.
المؤلفون: Huong DTL; Faculty of Pharmacy, PHENIKAA University, Ha Dong, Hanoi, Vietnam., Hang NT; Faculty of Pharmacy, PHENIKAA University, Ha Dong, Hanoi, Vietnam., Ly NK; Faculty of Pharmacy, PHENIKAA University, Ha Dong, Hanoi, Vietnam., Nhat NH; Faculty of Pharmacy, PHENIKAA University, Ha Dong, Hanoi, Vietnam., Huong NTL; Thanh Nhan Hospital, Hai Ba Trung, Hanoi, Vietnam., Hue LTP; Thanh Nhan Hospital, Hai Ba Trung, Hanoi, Vietnam., Anh DTL; Thanh Nhan Hospital, Hai Ba Trung, Hanoi, Vietnam., Dung BTK; Thanh Nhan Hospital, Hai Ba Trung, Hanoi, Vietnam., Phuong PM; Faculty of Pharmacy, PHENIKAA University, Ha Dong, Hanoi, Vietnam., Lan LT; Faculty of Pharmacy, PHENIKAA University, Ha Dong, Hanoi, Vietnam., Tung TT; Faculty of Pharmacy, PHENIKAA University, Ha Dong, Hanoi, Vietnam., Hieu NN; Faculty of Pharmacy, PHENIKAA University, Ha Dong, Hanoi, Vietnam., Ly NH; Faculty of Pharmacy, PHENIKAA University, Ha Dong, Hanoi, Vietnam.
المصدر: PloS one [PLoS One] 2023 Aug 23; Vol. 18 (8), pp. e0289825. Date of Electronic Publication: 2023 Aug 23 (Print Publication: 2023).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/epidemiology , Drug-Related Side Effects and Adverse Reactions*/epidemiology, Humans ; Outpatients ; Cross-Sectional Studies ; Vietnam/epidemiology ; Hospitals ; Medication Adherence
مستخلص: Introduction: Drug-related problems (DRPs) are common in clinical practice and occur at all stages of the medication process. The major factor contributing to DRPs is prescription, although patients' poor adherence to treatment is also a significant factor. This study evaluated type 2 diabetes outpatients in a hospital in Vietnam for drug-related problems (DRPs) and related variables.
Methods: A cross-sectional descriptive study was conducted on 495 outpatients who met the criteria and 157 people agreed to participate in the interview. Medication order review and medication adherence review were used to identify DRPs. The types of DRP were based on the Pharmaceutical Care Network Europe (PCNE) categories version 9.0. The identification and assessment DRPs were carried out by clinical pharmacists and get agreed upon by physicians who had not directly prescribed patients who participated in the study.
Results: A total of 762 DRPs were identified via prescribing review process, the average number of DRP on each prescription was 1.54±1.07, while 412 DRPs were determined through patient interviewing. The most frequent DRPs were "ADR (Adverse Drug Reaction) occurring" (68.8%). The main causes were "patient is unable to understand instructions properly" or "patient is not properly instructed", "patient stores insulin inappropriately", "patient decides to use unnecessary drugs" and "patient intentionally uses/takes less drug than prescribed or does not take the drug at all for whatever reason" which accounted for 65.0%, 41.4%, 38.2%, and 28.7%, respectively. From the prescribing review, the most observed DRPs were "Inappropriate drug according to guidelines/formulary" and "No or incomplete drug treatment in spite of existing indication", accounting for 45.0% and 42.9%, respectively. There was a significant association between age (OR 3.38, 95% CI: 1.01-11.30), duration of diabetes (OR 3.61, 95%CI: 1.11-11.74), presence of comorbidity (OR 5.31, 95%CI: 1.97-14.30), polypharmacy (OR: 2.95, 95%CI: 1.01-8.72) and DRPs. In patients, poor knowledge of antidiabetic agents was the main reason to lack adherence and occurring ADR (OR 2.73, 95%CI: 1.32-5.66, p = 0.007 and OR 2.49, 95%CI: 1.54-4.03, p = 0.001 respectively).
Conclusion: DRPs occurred in the prescribing stage and relating to patient's behavior of drug administration was high. Clear identification of DRPs and the associated factors are essential for building the intervention process to improve effectiveness and safety in the treatment of type 2 diabetes mellitus patients.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Huong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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تواريخ الأحداث: Date Created: 20230823 Date Completed: 20230825 Latest Revision: 20230828
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10446199
DOI: 10.1371/journal.pone.0289825
PMID: 37611036
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0289825