دورية أكاديمية
An Animal Model of Functional Tricuspid Regurgitation by Leaflet Tethering Using Image-Guided Chordal Encircling Snares.
العنوان: | An Animal Model of Functional Tricuspid Regurgitation by Leaflet Tethering Using Image-Guided Chordal Encircling Snares. |
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المؤلفون: | Onohara D; Structural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center at the Emory University Hospital Midtown, Atlanta, GA, USA.; Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA, USA., Silverman M; Structural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center at the Emory University Hospital Midtown, Atlanta, GA, USA.; Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA, USA., Suresh KS; Structural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center at the Emory University Hospital Midtown, Atlanta, GA, USA.; Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA, USA., Xu D; Structural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center at the Emory University Hospital Midtown, Atlanta, GA, USA.; Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA, USA., He Q; Structural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center at the Emory University Hospital Midtown, Atlanta, GA, USA.; Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA, USA., King CL; Structural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center at the Emory University Hospital Midtown, Atlanta, GA, USA.; Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA, USA., Tom SK; Structural Heart Research and Innovation Laboratory, Carlyle Fraser Heart Center at the Emory University Hospital Midtown, Atlanta, GA, USA.; Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA, USA., Kalra K; Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA, USA., Padala M; Nyra Medical, Inc., Decatur, GA, USA. psmuralidhar@gmail.com. |
المصدر: | Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2024 Apr; Vol. 17 (2), pp. 417-425. Date of Electronic Publication: 2023 Aug 24. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 101468585 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-5395 (Electronic) Linking ISSN: 19375387 NLM ISO Abbreviation: J Cardiovasc Transl Res Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: New York, NY : Springer |
مواضيع طبية MeSH: | Tricuspid Valve Insufficiency*/physiopathology , Tricuspid Valve Insufficiency*/diagnostic imaging , Tricuspid Valve Insufficiency*/surgery , Tricuspid Valve*/physiopathology , Tricuspid Valve*/diagnostic imaging , Tricuspid Valve*/surgery , Disease Models, Animal* , Chordae Tendineae*/physiopathology , Chordae Tendineae*/diagnostic imaging , Chordae Tendineae*/surgery, Animals ; Sus scrofa ; Ultrasonography, Interventional ; Swine ; Cardiac Catheterization/instrumentation ; Echocardiography, Doppler, Color |
مستخلص: | Several interventional therapies are in development to treat functional tricuspid regurgitation. Most have failed to achieve adequate efficacy, as animal models of this lesion are lacking. We developed a new image-guided technique in swine, by tethering the tricuspid valve chordae using echo-guided chordal encircling snares. Five swine underwent baseline echocardiographic assessment of tricuspid valve function, followed by echo-guided placement of snares that encircle the chordae inserting into the anterior and posterior tricuspid valve leaflets. Tethering these snares and stabilizing them on the right ventricle caused the regurgitant fraction to increase from 8.48±5.38% to 48.76±12.5%, and the valve tenting area to increase from 60.26±52.19 to 160.9±86.92 mm 2 . Image-guided chordal encircling snares could reproducibly induce clinically significant levels of functional tricuspid regurgitation and create a valve geometry like that seen in patients, providing a new animal model for use to study novel interventional devices. (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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معلومات مُعتمدة: | R01 HL133667 United States HL NHLBI NIH HHS; R01 HL135145 United States HL NHLBI NIH HHS; R01 HL140325 United States HL NHLBI NIH HHS |
فهرسة مساهمة: | Keywords: Right heart failure; Transcatheter tricuspid valve repair; Transcatheter tricuspid valve replacement; Tricuspid regurgitation |
تواريخ الأحداث: | Date Created: 20230824 Date Completed: 20240426 Latest Revision: 20240430 |
رمز التحديث: | 20240430 |
DOI: | 10.1007/s12265-023-10424-3 |
PMID: | 37615887 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1937-5395 |
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DOI: | 10.1007/s12265-023-10424-3 |