دورية أكاديمية
أعرض في EDS

Schizophrenia Patients Discharged on Clozapine Plus Long-Acting Injectable Antipsychotics From a Public Psychiatric Hospital in Taiwan, 2006-2021.

التفاصيل البيبلوغرافية
العنوان: Schizophrenia Patients Discharged on Clozapine Plus Long-Acting Injectable Antipsychotics From a Public Psychiatric Hospital in Taiwan, 2006-2021.
المؤلفون: Lin TC; Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan., Lin CH; Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan.; Department of Psychiatry, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.
المصدر: The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2023 Nov 24; Vol. 26 (11), pp. 808-816.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9815893 Publication Model: Print Cited Medium: Internet ISSN: 1469-5111 (Electronic) Linking ISSN: 14611457 NLM ISO Abbreviation: Int J Neuropsychopharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Oxford Oxford University Press
Original Publication: Cambridge, [England] : Cambridge University Press,
مواضيع طبية MeSH: Antipsychotic Agents*/therapeutic use , Clozapine*/therapeutic use , Schizophrenia*/drug therapy , Schizophrenia*/chemically induced, Humans ; Administration, Oral ; Delayed-Action Preparations/therapeutic use ; Hospitals, Psychiatric ; Patient Discharge ; Taiwan
مستخلص: Background: Some schizophrenia patients treated with clozapine experience an inadequate response and adherence problems. The purpose of this study was to compare time to rehospitalization within 6 months in schizophrenia patients discharged on 3 clozapine regimens. Additionally, the temporal trend of prescription rate in each group was also explored.
Methods: Schizophrenia patients discharged from the study hospital from January 1, 2006, to December 31, 2021, (n = 3271) were included in the analysis. The type of clozapine prescribed at discharge was divided into 3 groups: clozapine plus long-acting injectable antipsychotics (clozapine + LAIs), clozapine plus other oral antipsychotics (clozapine + OAPs), and clozapine monotherapy. Survival analysis was used to compare time to rehospitalization within 6 months after discharge among the 3 groups. The temporal trend in the prescription rate of each group was analyzed using the Cochran-Armitage Trend test.
Results: Patients discharged on clozapine + LAIs had a significantly longer time to rehospitalization than those on clozapine + OAPs or clozapine monotherapy. The prescription rates of clozapine + LAIs and clozapine + OAPs significantly increased over time, whereas the prescription rates of clozapine monotherapy significantly decreased.
Conclusions: Compared with the clozapine + OAPs group, the clozapine + LAIs group had a lower risk of rehospitalization and a lower dose of clozapine prescribed. Therefore, if a second antipsychotic is required for patients who are taking clozapine alone, LAIs should be considered earlier.
(© The Author(s) 2023. Published by Oxford University Press on behalf of CINP.)
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فهرسة مساهمة: Keywords: Schizophrenia; clozapine; long-acting injectable antipsychotics; rehospitalization; temporal trend
المشرفين على المادة: 0 (Antipsychotic Agents)
J60AR2IKIC (Clozapine)
0 (Delayed-Action Preparations)
تواريخ الأحداث: Date Created: 20230824 Date Completed: 20231130 Latest Revision: 20231130
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10674076
DOI: 10.1093/ijnp/pyad053
PMID: 37616565
قاعدة البيانات: MEDLINE
الوصف
تدمد:1469-5111
DOI:10.1093/ijnp/pyad053