دورية أكاديمية
Structured Framework for Multidisciplinary Parent Counseling and Medical Interventions for Fetuses and Infants with Trisomy 13 or Trisomy 18.
| العنوان: | Structured Framework for Multidisciplinary Parent Counseling and Medical Interventions for Fetuses and Infants with Trisomy 13 or Trisomy 18. |
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| المؤلفون: | Kim AJH; Department of Pediatrics, Oregon Health and Science University, Portland, Oregon., Marshall M; Department of Pediatrics, Oregon Health and Science University, Portland, Oregon., Gievers L; Department of Pediatrics, Oregon Health and Science University, Portland, Oregon., Tate T; Department of Pediatrics, Oregon Health and Science University, Portland, Oregon., Taub S; Department of Pediatrics, Oregon Health and Science University, Portland, Oregon., Dukhovny S; Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon., Ronai C; Department of Pediatrics, Oregon Health and Science University, Portland, Oregon., Madriago EJ; Department of Pediatrics, Oregon Health and Science University, Portland, Oregon. |
| المصدر: | American journal of perinatology [Am J Perinatol] 2024 May; Vol. 41 (S 01), pp. e2666-e2673. Date of Electronic Publication: 2023 Aug 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Thieme-Stratton Country of Publication: United States NLM ID: 8405212 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-8785 (Electronic) Linking ISSN: 07351631 NLM ISO Abbreviation: Am J Perinatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Thieme-Stratton, 1983- |
| مواضيع طبية MeSH: | Trisomy 18 Syndrome*/therapy , Trisomy 18 Syndrome*/diagnosis , Trisomy 13 Syndrome*/therapy , Trisomy 13 Syndrome*/diagnosis , Chromosomes, Human, Pair 18* , Trisomy*/diagnosis , Parents* , Chromosomes, Human, Pair 13* , Chromosome Disorders*/diagnosis , Chromosome Disorders*/therapy, Humans ; Infant, Newborn ; Female ; Pregnancy ; Counseling ; Genetic Counseling |
| مستخلص: | Objective: Trisomy 13 (T13) and 18 (T18) are aneuploidies associated with multiple structural congenital anomalies and high rates of fetal demise and neonatal mortality. Historically, patients with either one of these diagnoses have been treated similarly with exclusive comfort care rather than invasive interventions or intensive care, despite a wide phenotypic variation and substantial variations in survival length. However, surgical interventions have been on the rise in this population in recent years without clearly elucidated selection criterion. Our objective was to create a standardized approach to counseling expectant persons and parents of newborns with T13/T18 in order to provide collaborative and consistent counseling and thoughtful approach to interventions such as surgery. Study Design: This article describes our process and presents our resulting clinical care guideline. Results: We formed a multi- and interdisciplinary committee. We used published literature when available and otherwise expert opinion to develop an approach to care featuring individualized assessment of the patient to estimate qualitative mortality risk and potential to benefit from intensive care and/or surgeries centered within an ethical framework. Conclusion: Through multidisciplinary collaboration, we successfully created a patient-centered approach for counseling families facing a diagnosis of T13/T18. Other institutions may use our approach as a model for developing their own standardized approach. Key Points: · Trisomy 13 and trisomy 18 are associated with high but variable morbidity and mortality.. · Research on which patients are most likely to benefit from surgery is lacking.. · We present our institution's framework to counsel families with fetal/neonatal T13/T18.. Competing Interests: None declared. (Thieme. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20230824 Date Completed: 20240605 Latest Revision: 20240730 |
| رمز التحديث: | 20240730 |
| DOI: | 10.1055/s-0043-1772748 |
| PMID: | 37619598 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-8785 |
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| DOI: | 10.1055/s-0043-1772748 |