دورية أكاديمية
Understanding Fibroblast Heterogeneity in Form and Function.
| العنوان: | Understanding Fibroblast Heterogeneity in Form and Function. |
|---|---|
| المؤلفون: | Parker JB; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Valencia C; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA., Akras D; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA., DiIorio SE; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Griffin MF; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA., Longaker MT; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA., Wan DC; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA. |
| المصدر: | Biomedicines [Biomedicines] 2023 Aug 14; Vol. 11 (8). Date of Electronic Publication: 2023 Aug 14. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, [2013]- |
| مستخلص: | Historically believed to be a homogeneous cell type that is often overlooked, fibroblasts are more and more understood to be heterogeneous in nature. Though the mechanisms behind how fibroblasts participate in homeostasis and pathology are just beginning to be understood, these cells are believed to be highly dynamic and play key roles in fibrosis and remodeling. Focusing primarily on fibroblasts within the skin and during wound healing, we describe the field's current understanding of fibroblast heterogeneity in form and function. From differences due to embryonic origins to anatomical variations, we explore the diverse contributions that fibroblasts have in fibrosis and plasticity. Following this, we describe molecular techniques used in the field to provide deeper insights into subpopulations of fibroblasts and their varied roles in complex processes such as wound healing. Limitations to current work are also discussed, with a focus on future directions that investigators are recommended to take in order to gain a deeper understanding of fibroblast biology and to develop potential targets for translational applications in a clinical setting. |
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| معلومات مُعتمدة: | T32 GM145402 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: dermis; fibroblast; fibrosis; heterogeneity; wound healing |
| تواريخ الأحداث: | Date Created: 20230826 Latest Revision: 20231024 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10452440 |
| DOI: | 10.3390/biomedicines11082264 |
| PMID: | 37626760 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2227-9059 |
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| DOI: | 10.3390/biomedicines11082264 |