دورية أكاديمية
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Analysis of the Effect of the TRPC4/TRPC5 Blocker, ML204, in Sucrose-Induced Metabolic Imbalance.

التفاصيل البيبلوغرافية
العنوان: Analysis of the Effect of the TRPC4/TRPC5 Blocker, ML204, in Sucrose-Induced Metabolic Imbalance.
المؤلفون: Araújo MC; Programa de Pós-Graduação, Universidade CEUMA, São Luís 65075-120, MA, Brazil., Soczek SHS; Programa de Pós-Graduação em Biotecnologia Aplicada à Saúde da Criança e do Adolescente, Faculdades Pequeno Príncipe, Curitiba 80230-020, PR, Brazil.; Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba 80250-060, PR, Brazil., Pontes JP; Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Maranhão, São Luís 565085-080, MA, Brazil., Pinto BAS; Departamento de Ciências Fisiológicas, Universidade Federal do Maranhão, São Luís 565085-080, MA, Brazil., França LM; Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Maranhão, São Luís 565085-080, MA, Brazil., Soley BDS; Departamento de Farmacologia, Universidade Federal do Paraná, Curitiba 81531-980, PR, Brazil., Santos GS; Programa de Pós-Graduação, Universidade CEUMA, São Luís 65075-120, MA, Brazil., Saminez WFS; Programa de Pós-Graduação, Universidade CEUMA, São Luís 65075-120, MA, Brazil., Fernandes FKM; Programa de Pós-Graduação, Universidade CEUMA, São Luís 65075-120, MA, Brazil., Lima JLDC; Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Maranhão, São Luís 565085-080, MA, Brazil., Maria-Ferreira D; Programa de Pós-Graduação em Biotecnologia Aplicada à Saúde da Criança e do Adolescente, Faculdades Pequeno Príncipe, Curitiba 80230-020, PR, Brazil.; Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba 80250-060, PR, Brazil., Rodrigues JFS; Programa de Pós-Graduação, Universidade CEUMA, São Luís 65075-120, MA, Brazil., Quintão NLM; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai, Itajaí 88302-901, SC, Brazil., Monteiro-Neto V; Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Maranhão, São Luís 565085-080, MA, Brazil., Paes AMA; Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Maranhão, São Luís 565085-080, MA, Brazil., Fernandes ES; Programa de Pós-Graduação em Biotecnologia Aplicada à Saúde da Criança e do Adolescente, Faculdades Pequeno Príncipe, Curitiba 80230-020, PR, Brazil.; Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba 80250-060, PR, Brazil.
المصدر: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 Aug 03; Vol. 16 (8). Date of Electronic Publication: 2023 Aug 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c2004-
مستخلص: Sugar-induced metabolic imbalances are a major health problem since an excessive consumption of saccharides has been linked to greater obesity rates at a global level. Sucrose, a disaccharide composed of 50% glucose and 50% fructose, is commonly used in the food industry and found in a range of fast, restaurant, and processed foods. Herein, we investigated the effects of a TRPC4/TRPC5 blocker, ML204, in the metabolic imbalances triggered by early exposure to sucrose-enriched diet in mice. TRPC4 and TRPC5 belong to the family of non-selective Ca +2 channels known as transient receptor potential channels. High-sucrose (HS)-fed animals with hyperglycaemia and dyslipidaemia, were accompanied by increased body mass index. mesenteric adipose tissue accumulation with larger diameter cells and hepatic steatosis in comparison to those fed normal diet. HS mice also exhibited enhanced adipose, liver, and pancreas TNFα and VEGF levels. ML204 exacerbated hyperglycaemia, dyslipidaemia, fat tissue deposition, hepatic steatosis, and adipose tissue and liver TNFα in HS-fed mice. Normal mice treated with the blocker had greater hepatic steatosis and adipose tissue cell numbers/diameter than those receiving vehicle, but showed no significant changes in tissue inflammation, glucose, and lipid levels. The results indicate that TRPC4/TRPC5 protect against the metabolic imbalances caused by HS ingestion.
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معلومات مُعتمدة: grant numbers: 305676/2019-9 and 408053/2018-6 to E.S.F; 315072/2020-2 to V.M.-N.; and 302195/2022-0 to D.M-F National Council for Scientific and Technological Development; grant numbers: IECT-05738/18 to E.S.F.; and ACT-05691/21, and ACT 01784-21 to V.M.-N. Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão; Programa Pró-Amazônia; grant number: 3325/2013; finance code 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior; na Instituto de Pesquisa Pelé Pequeno Príncipe; na INCT-INOVAMED
فهرسة مساهمة: Keywords: TRPC4 and TRPC5 channels; fat deposition; hepatic steatosis; high sucrose intake; metabolic changes
تواريخ الأحداث: Date Created: 20230826 Latest Revision: 20230829
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10459798
DOI: 10.3390/ph16081100
PMID: 37631015
قاعدة البيانات: MEDLINE
الوصف
تدمد:1424-8247
DOI:10.3390/ph16081100