دورية أكاديمية
أعرض في EDS

Long-Term Impact of Direct-Acting Antivirals on Liver Fibrosis and Survival in HCV-Infected Liver Transplant Recipients.

التفاصيل البيبلوغرافية
العنوان: Long-Term Impact of Direct-Acting Antivirals on Liver Fibrosis and Survival in HCV-Infected Liver Transplant Recipients.
المؤلفون: Gambato M; Multivisceral Transplant and Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, Azienda Ospedale-Università Padova, Via Giustiniani 2, 35100 Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35100 Padova, Italy., Manuli C; Multivisceral Transplant and Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, Azienda Ospedale-Università Padova, Via Giustiniani 2, 35100 Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35100 Padova, Italy., Lynch EN; Multivisceral Transplant and Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, Azienda Ospedale-Università Padova, Via Giustiniani 2, 35100 Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35100 Padova, Italy., Battistella S; Multivisceral Transplant and Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, Azienda Ospedale-Università Padova, Via Giustiniani 2, 35100 Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35100 Padova, Italy., Germani G; Multivisceral Transplant and Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, Azienda Ospedale-Università Padova, Via Giustiniani 2, 35100 Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35100 Padova, Italy., Senzolo M; Multivisceral Transplant and Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, Azienda Ospedale-Università Padova, Via Giustiniani 2, 35100 Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35100 Padova, Italy., Zanetto A; Multivisceral Transplant and Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, Azienda Ospedale-Università Padova, Via Giustiniani 2, 35100 Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35100 Padova, Italy., Ferrarese A; Multivisceral Transplant and Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, Azienda Ospedale-Università Padova, Via Giustiniani 2, 35100 Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35100 Padova, Italy., Vitale A; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35100 Padova, Italy.; Hepatobiliary Urgery and Liver Transplantation, Department of Surgery, Oncology and Gastroenterology, Azienda Ospedale-Università Padova, 35100 Padova, Italy., Gringeri E; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35100 Padova, Italy.; Hepatobiliary Urgery and Liver Transplantation, Department of Surgery, Oncology and Gastroenterology, Azienda Ospedale-Università Padova, 35100 Padova, Italy., Cillo U; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35100 Padova, Italy.; Hepatobiliary Urgery and Liver Transplantation, Department of Surgery, Oncology and Gastroenterology, Azienda Ospedale-Università Padova, 35100 Padova, Italy., Burra P; Multivisceral Transplant and Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, Azienda Ospedale-Università Padova, Via Giustiniani 2, 35100 Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35100 Padova, Italy., Russo FP; Multivisceral Transplant and Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, Azienda Ospedale-Università Padova, Via Giustiniani 2, 35100 Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, 35100 Padova, Italy.
المصدر: Viruses [Viruses] 2023 Aug 07; Vol. 15 (8). Date of Electronic Publication: 2023 Aug 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Hepatitis C*/drug therapy , Hepatitis C*/therapy , Liver Transplantation* , Antiviral Agents*/administration & dosage , Liver*/drug effects , Liver*/pathology , Liver*/physiology, Humans ; Fibrosis ; Retrospective Studies ; Male ; Female ; Middle Aged ; Survival Analysis ; Hypertension, Portal/therapy
مستخلص: (1) Background: Little is known about the long-term impact of sustained virological response (SVR) on fibrosis progression and patient survival in liver transplantation (LT) recipients treated with direct-acting antivirals (DAAs). We investigated liver fibrosis evolution and patient survival in hepatitis C virus (HCV)-infected patients receiving DAAs after LT. (2) Methods: All consecutive HCV-infected patients treated with DAAs after LT between May 2014 and January 2019 were considered. The clinical and virological features were registered at the baseline and during the follow-up. The liver fibrosis was assessed by liver biopsy and/or transient elastography (TE) at the baseline and at least 1 year after the end of treatment (EoT). (3) Results: A total of 136 patients were included. The SVR12 was 78% after the first treatment and 96% after retreatment. After the SVR12, biochemical tests improved at the EoT and remained stable throughout the 3-year follow-up. Liver fibrosis improved after the SVR12 ( p < 0.001); nearly half of the patients with advanced liver fibrosis experienced an improvement of an F ≤ 2. The factors associated with lower survival in SVR12 patients were the baseline platelet count ( p = 0.04) and creatinine level ( p = 0.04). (4) Conclusions: The long-term follow-up data demonstrated that SVR12 was associated with an improvement in hepatic function, liver fibrosis, and post-LT survival, regardless of the baseline liver fibrosis. The presence of portal hypertension before the DAAs has an impact on patient survival, even after SVR12.
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فهرسة مساهمة: Keywords: DAAs; hepatitis C virus; liver transplantation
المشرفين على المادة: 0 (Antiviral Agents)
تواريخ الأحداث: Date Created: 20230826 Date Completed: 20230830 Latest Revision: 20230907
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10458217
DOI: 10.3390/v15081702
PMID: 37632044
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4915
DOI:10.3390/v15081702