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Xanthine oxidase, α-glucosidase and α-amylase inhibitory activities of the essential oil from Piper lolot : In vitro and in silico studies.

التفاصيل البيبلوغرافية
العنوان: Xanthine oxidase, α-glucosidase and α-amylase inhibitory activities of the essential oil from Piper lolot : In vitro and in silico studies.
المؤلفون: Nguyen TK; Institute of Applied Life Sciences, Dong A University, 33 Xo Viet Nghe Tinh, Hai Chau District, Da Nang, Viet Nam.; Scientific Management Department, Dong A University, Da Nang, Viet Nam., Thuy Thi Tran L; Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue City, Thua Thien Hue, Viet Nam., Ho Viet D; Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue City, Thua Thien Hue, Viet Nam., Thai PH; Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, Vietnam Academy of Science and Technology, 321 Huynh Thuc Khang, Hue City, Thua Thien Hue, Viet Nam., Ha TP; Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, Vietnam Academy of Science and Technology, 321 Huynh Thuc Khang, Hue City, Thua Thien Hue, Viet Nam., Ty PV; Faculty of Chemistry, University of Education, Hue University, 34 Le Loi, Hue City, Thua Thien Hue, Viet Nam., Duc LP; Hue Medical College, People's Committee of Thua Thien Hue Province, 01 Nguyen Truong to, Hue City, Thua Thien Hue, Viet Nam., Ton That Huu D; Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, Vietnam Academy of Science and Technology, 321 Huynh Thuc Khang, Hue City, Thua Thien Hue, Viet Nam., Cuong LCV; Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, Vietnam Academy of Science and Technology, 321 Huynh Thuc Khang, Hue City, Thua Thien Hue, Viet Nam.; Centre for Conservation of Vietnam Natural Resources and Rescue of Animals and Plants, Vietnam National Museum of Nature, Vietnam Academy of Science and Technology, Phong My, Phong Dien, Thua Thien Hue, Viet Nam.
المصدر: Heliyon [Heliyon] 2023 Aug 15; Vol. 9 (8), pp. e19148. Date of Electronic Publication: 2023 Aug 15 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: Introduction: Piper lolot is a species of herb used as a popular food in Vietnam. Furthermore, the species has been used as a Vietnamese traditional medicine to treat many diseases.
Methods: Chemical constituents in the essential oil from leaves of Piper lolot were determined using GC/MS analysis. The anti-gout and anti-diabetic activities of the essential oil were determined through the inhibitory assays against xanthine oxidase, α-glucosidase and α-amylase enzymes. In addition, molecular docking simulations were used to elucidate the inhibitory mechanism between the main compounds and the enzymes.
Results: The dominant constituents of the Piper lolot essential oils were determined as β -caryophyllene (20.6%), β -bisabolene (11.6%), β -selinene (8.4%), β -elemene (7.7%), trans -muurola-4(14),5-diene (7.4%), and ( E )- β -ocimene (6.7%). The essential oil displayed xanthine oxidase, α -amylase, and α -glucosidase inhibitory activities with IC 50 values of 28.4, 130.6, and 59.1 μg/mL, respectively. The anti-gout and anti-diabetic activities of the essential oil from the P. lolot species are reported for the first time. Furthermore, molecular docking simulation was consistent to in vitro experiments.
Conclusion: The present study provides initial evidence that the essential oil of P. lolot may be a potential natural source to develop new diabetes preparations.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2023 The Authors. Published by Elsevier Ltd.)
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فهرسة مساهمة: Keywords: Essential oil; Piper lolot; Xanthine oxidase; α-amylase; α-glucosidase
تواريخ الأحداث: Date Created: 20230828 Latest Revision: 20230829
رمز التحديث: 20230830
مُعرف محوري في PubMed: PMC10458695
DOI: 10.1016/j.heliyon.2023.e19148
PMID: 37636421
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2023.e19148