دورية أكاديمية
Prognostic value of myocardial performance index in individuals with type 1 and type 2 diabetes: Thousand&1 and Thousand&2 studies.
| العنوان: | Prognostic value of myocardial performance index in individuals with type 1 and type 2 diabetes: Thousand&1 and Thousand&2 studies. |
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| المؤلفون: | Bahrami HSZ; Department of Cardiology, Copenhagen University Hospital, Amager & Hvidovre, Kettegård Alle 30, 2650 Hvidovre, Denmark.; Department of Clinical Research, Steno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730 Herlev, Denmark., Jørgensen PG; Department of Clinical Research, Steno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730 Herlev, Denmark.; Department of Cardiology, Copenhagen University Hospital, Herlev & Gentofte, Borgmester Ib Juuls Vej 1, 2730 Herlev, Denmark., Hove JD; Department of Cardiology, Copenhagen University Hospital, Amager & Hvidovre, Kettegård Alle 30, 2650 Hvidovre, Denmark.; Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen, Denmark., Dixen U; Department of Cardiology, Copenhagen University Hospital, Amager & Hvidovre, Kettegård Alle 30, 2650 Hvidovre, Denmark.; Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen, Denmark., Biering-Sørensen T; Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Gentofte Hospitalsvej 1, 2900 Hellerup, Denmark., Rossing P; Department of Clinical Research, Steno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730 Herlev, Denmark.; Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen, Denmark., Jensen MT; Department of Cardiology, Copenhagen University Hospital, Amager & Hvidovre, Kettegård Alle 30, 2650 Hvidovre, Denmark.; Department of Clinical Research, Steno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730 Herlev, Denmark.; William Harvey Research Institute, NIHR Barts Biomedical Centre, Queen Mary University London, Charterhouse Square, London EC1M 6BQ, UK. |
| المصدر: | European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2023 Oct 27; Vol. 24 (11), pp. 1555-1562. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101573788 Publication Model: Print Cited Medium: Internet ISSN: 2047-2412 (Electronic) Linking ISSN: 20472404 NLM ISO Abbreviation: Eur Heart J Cardiovasc Imaging Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Oxford University Press |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 1*/complications , Diabetes Mellitus, Type 1*/diagnostic imaging , Heart Failure*/etiology, Humans ; Male ; Female ; Prognosis ; Prospective Studies ; Risk Factors |
| مستخلص: | Aims: Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in type 1 (T1D) and type 2 diabetes (T2D). Despite diabetes affects the myocardium, risk prediction models do not include myocardial function parameters. Myocardial performance index (MPI) reflects left ventricular function. The prognostic value of MPI has not been evaluated in large-scale diabetes populations. Methods and Results: We evaluated two prospective cohort studies: Thousand&1 (1093 individuals with T1D) and Thousand&2 (1030 individuals with T2D). Clinical data, including echocardiography, were collected at baseline. We collected follow-up data from national registries. We defined major adverse cardiovascular events (MACE) as incident events of hospital admission for acute coronary syndrome, heart failure, stroke, or all-cause mortality. For included individuals (56% male, 54 ± 15 years, MPI 0.51 ± 0.1, 63% T1D), follow-up was 100% after median of 5.3 years (range: 4.8-6.3). MPI was associated with MACE (HR 1.2, 95%CI 1.0-1.3, P = 0.012, per 0.10-unit increase) and heart failure (HR 1.3, 95%CI 1.1-1.6, P = 0.005, per 0.10-unit increase) after adjusting for clinical and echocardiographic variables. MPI predicted MACE and heart failure better in T1D than T2D (P = 0.031 for interaction). MPI added discriminatory power to the Steno T1 Risk Engine, based on clinical characteristics, in predicting MACE [area under the curve (AUC) from 0.77 to 0.79, P = 0.030] and heart failure (AUC from 0.77 to 0.83, P = 0.009) in T1D. Conclusion: MPI is independently associated with MACE and heart failure in T1D but not T2D and improves prediction in T1D. Echocardiographic assessment in T1D may enhance risk prediction. Competing Interests: Conflict of interest: P.G.J. reports lecture fees from Astra Zeneca. U.D. has been an invited speaker for and received research grants from Bayer. T.B.-S. reports grants to his institution from Amgen, AstraZeneca, Boehringer, GE Healthcare, Novo Nordisk, and Sanofi Pasteur; has been on the advisory board of Amgen, GSK, and Sanofi Pasteur; and has received honoraria from Bayer, GSK, Novartis, and Sanofi Pasteur. P.R. reports grants to his institution from Astra Zeneca, Bayer, and Novo Nordisk and has received honoraria from Abbott, Astellas, Astra Zeneca, Bayer, Boehringer Ingelheim, Eli Lilly, Novo Nordisk, and Sanofi (all fees to the institution). M.T.J. has been a consultant, on advisory boards, or invited speaker for Astra Zeneca, GE, Novo Nordisk, and Novartis. All other authors have declared no conflict of interest. (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| معلومات مُعتمدة: | European Foundation for the Study of Diabetes; Danish Heart Foundation; Novo Nordisk |
| فهرسة مساهمة: | Keywords: algorithms; cardiovascular diseases; diabetes; echocardiography |
| تواريخ الأحداث: | Date Created: 20230828 Date Completed: 20231030 Latest Revision: 20231203 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1093/ehjci/jead178 |
| PMID: | 37638773 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2047-2412 |
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| DOI: | 10.1093/ehjci/jead178 |