دورية أكاديمية
أعرض في EDS

Development and validation of a peripheral cell ratio and lactate score for differentiating status epilepticus from prolonged psychogenic nonepileptic seizures.

التفاصيل البيبلوغرافية
العنوان: Development and validation of a peripheral cell ratio and lactate score for differentiating status epilepticus from prolonged psychogenic nonepileptic seizures.
المؤلفون: Tan THL; Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.; Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia., Sanfilippo P; Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia., Colman B; Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.; Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia., Perucca P; Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.; Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Department of Neurology, Bladin-Berkovic Comprehensive Epilepsy Program, Austin Health, Melbourne, Victoria, Australia.; Epilepsy Research Centre, Department of Medicine (Austin Health), The University of Melbourne, Melbourne, Victoria, Australia., Kwan P; Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia., O'Brien TJ; Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.; Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia., Monif M; Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.; Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
المصدر: Epilepsia open [Epilepsia Open] 2023 Dec; Vol. 8 (4), pp. 1460-1473. Date of Electronic Publication: 2023 Sep 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101692036 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9239 (Electronic) Linking ISSN: 24709239 NLM ISO Abbreviation: Epilepsia Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hoboken, New Jersey : John Wiley & Sons, Inc., [2016]-
مواضيع طبية MeSH: Lactic Acid* , Status Epilepticus*/diagnosis, Humans ; Psychogenic Nonepileptic Seizures ; Retrospective Studies ; Leukocyte Count
مستخلص: Objective: Differentiating status epilepticus (SE) from prolonged psychogenic nonepileptic seizures (pPNES) can be difficult clinically. We aimed to define the utility of peripheral cell counts, cell ratios, and lactate levels in distinguishing SE from pPNES.
Methods: Retrospective two-center study investigating the sensitivity and specificity of acute (≤12 h of event offset) peripheral cell counts, cell ratios (neutrophil-lymphocyte ratio, neutrophil-monocyte ratio, monocyte-lymphocyte ratio, platelet-lymphocyte ratio, systemic immune-inflammatory index [SII], systemic inflammatory response index [SIRI]), and lactate levels in differentiating SE from pPNES. Patients were identified from two tertiary hospitals, with one forming the development cohort and the other the validation cohort. Using generalized additive models to generate biomarker vs time curves, optimal blood collection times were defined for set parameters. Three diagnostic scores combining neutrophil count, SII, or SIRI with lactate levels were developed and validated in separate cohorts.
Results: For the development cohort, 1262 seizure-like events were reviewed and 79 SE and 44 pPNES events were included. For the validation cohort, 241 events were reviewed and 20 SE and 11 pPNES events were included. Individually, the biomarkers generally had low sensitivity and reasonable specificity for differentiating SE from pPNES, with the neutrophil count, SIRI, and SII performing best with sensitivities of 0.65-0.84, specificities of 0.64-0.89, and ROC AUCs of 0.78-0.79. Lactate levels peaked at 60 min, while cell counts and ratios peaked after 240 min. Combining early peaking lactate levels and later peaking neutrophil count, SIRI or SII resulted in three scores that improved predictive potential with sensitivities of between 0.75 and 0.79, specificities between 0.93 and 1.00, and ROC AUCs of 0.89-0.91.
Significance: Lactate levels peak early post-SE, whereas cell counts and ratios do so later. The differing post-event time profiles of lactate levels vs neutrophil count, SIRI, and SII allow incorporation into three separate scores which can assist in differentiating SE from pPNES.
(© 2023 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)
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فهرسة مساهمة: Keywords: PNES; lactate; lymphocyte; monocyte; neutrophil; seizures
المشرفين على المادة: 33X04XA5AT (Lactic Acid)
تواريخ الأحداث: Date Created: 20230828 Date Completed: 20231204 Latest Revision: 20231205
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10690667
DOI: 10.1002/epi4.12822
PMID: 37641168
قاعدة البيانات: MEDLINE
الوصف
تدمد:2470-9239
DOI:10.1002/epi4.12822