دورية أكاديمية
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Genetic contribution of synapse-associated protein 97 to cerebellar functional connectivity changes in first-episode schizophrenia.

التفاصيل البيبلوغرافية
العنوان: Genetic contribution of synapse-associated protein 97 to cerebellar functional connectivity changes in first-episode schizophrenia.
المؤلفون: Xu X; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Maternal and Children's Health Research Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan, 528300, China., Luo S; Department of Radiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China., Wang X; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.; Institute of Neurology, Longjiang Hospital, the Third Affiliated Hospital of Guangdong Medical University, Shunde, 528300, China., Wen X; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China., Yin J; Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China., Luo X; Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China., He B; Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China., Liang C; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China., Xiong S; Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China., Zhu D; Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China., Lv D; Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China., Dai Z; Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China., Lin J; Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China., Li Y; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China., Lin Z; Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China., Chen W; Department of Radiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China., Luo Z; Department of Radiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China. gdmcfsjd@163.com., Wang Y; Maternal and Children's Health Research Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan, 528300, China. wangyajuny1977@aliyun.com., Ma G; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China. sihan1107@126.com.; Maternal and Children's Health Research Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan, 528300, China. sihan1107@126.com.
المصدر: BMC psychiatry [BMC Psychiatry] 2023 Aug 29; Vol. 23 (1), pp. 630. Date of Electronic Publication: 2023 Aug 29.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X (Electronic) Linking ISSN: 1471244X NLM ISO Abbreviation: BMC Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Discs Large Homolog 1 Protein*/genetics , Schizophrenia*/diagnostic imaging , Schizophrenia*/genetics, Humans ; Alleles ; Asian People ; Cerebellum/diagnostic imaging
مستخلص: Our previous study data suggested that the synapse-associated protein 97 (SAP97) rs3915512 polymorphism is significantly related to clinical performance in schizophrenia. The cerebellum exhibits abundant expression of SAP97, which is involved with negative symptoms, cognition and emotion in schizophrenia. As functional dysconnectivity with the cortical-subcortical-cerebellar circuitry has been widely shown in patients with schizophrenia, cortical-subcortical-cerebellar dysconnectivity can therefore be considered a possible intermediate phenotype that connects risk genes with schizophrenia. In this study, resting-state functional magnetic resonance imaging (fMRI) was applied to evaluate whether the SAP97 rs3915512 polymorphism changes cortical/subcortical-cerebellar resting-state functional connectivity (RSFC) in 104 Han Chinese subjects (52 first-episode schizophrenia (FES) patients and 52 matched healthy controls (HCs)). To examine RSFC between cortical/subcortical regions and the cerebellum, a ROI (region of interest)-wise functional connectivity analysis was conducted. The association between abnormal cortical/subcortical-cerebellar connectivity and clinical manifestation was further assessed in FES patients with different genotypes. The interactive effect of disease and genotype on RSFC was found between the frontal gyrus (rectus) and cerebellum. A positive correlation was suggested between RSFC in the cerebellum and the hostility scores in FES patients with the A allele, and no correlation was found in FES patients with the TT genotype. The current findings identified that SAP97 may be involved in the process of mental symptoms in FES patients via cerebellar connectivity depending on the rs3915512 polymorphism genotype.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
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فهرسة مساهمة: Keywords: Cerebellum; Resting-state functional connectivity; Rs3915512; SAP97; Schizophrenia
المشرفين على المادة: 0 (Discs Large Homolog 1 Protein)
0 (DLG1 protein, human)
تواريخ الأحداث: Date Created: 20230829 Date Completed: 20230831 Latest Revision: 20231123
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10464201
DOI: 10.1186/s12888-023-05036-9
PMID: 37644438
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-244X
DOI:10.1186/s12888-023-05036-9