دورية أكاديمية
Neurological Impairment in Critically Ill Patients on Dialysis: Research Letter for the INCOGNITO-AKI Feasibility Study.
العنوان: | Neurological Impairment in Critically Ill Patients on Dialysis: Research Letter for the INCOGNITO-AKI Feasibility Study. |
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المؤلفون: | Jawa NA; Centre for Neuroscience Studies, School of Medicine, Queen's Health Sciences, Queen's University, Kingston, ON, Canada., Silver SA; Division of Nephrology, Department of Medicine, Queen's University, Kingston, ON, Canada., Holden RM; Division of Nephrology, Department of Medicine, Queen's University, Kingston, ON, Canada., Scott SH; Centre for Neuroscience Studies, School of Medicine, Queen's Health Sciences, Queen's University, Kingston, ON, Canada.; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada., Day AG; Kingston General Health Research Institute, Kingston, ON, Canada.; Department of Public Health Sciences, Queen's University, Kingston, ON, Canada., Norman PA; Kingston General Health Research Institute, Kingston, ON, Canada., Kwan BYM; Department of Diagnostic Radiology, Queen's University, Kingston, ON, Canada., Maslove DM; Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada.; Department of Critical Care Medicine, Kingston Health Sciences Centre, Kingston, ON, Canada., Muscedere J; Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada.; Department of Critical Care Medicine, Kingston Health Sciences Centre, Kingston, ON, Canada., Boyd JG; Centre for Neuroscience Studies, School of Medicine, Queen's Health Sciences, Queen's University, Kingston, ON, Canada.; Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada.; Department of Critical Care Medicine, Kingston Health Sciences Centre, Kingston, ON, Canada.; Division of Neurology, Department of Medicine, Queen's University, Kingston, ON, Canada. |
المصدر: | Canadian journal of kidney health and disease [Can J Kidney Health Dis] 2023 Aug 24; Vol. 10, pp. 20543581231192743. Date of Electronic Publication: 2023 Aug 24 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: SAGE Publications Country of Publication: England NLM ID: 101640242 Publication Model: eCollection Cited Medium: Print ISSN: 2054-3581 (Print) Linking ISSN: 20543581 NLM ISO Abbreviation: Can J Kidney Health Dis Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: London : SAGE Publications Original Publication: London : BioMed Central, 2014- |
مستخلص: | Background: Acute kidney injury (AKI) resulting in kidney replacement therapy is rising among critically ill adults. Long-term kidney replacement therapy and critical illness are independently linked to acute and prolonged cognitive impairment, and structural brain pathology. Poor regional cerebral oxygenation (rSO Objective: To assess the feasibility of testing the association between intradialytic rSO Design: Longitudinal observational study. Setting and Participants: We enrolled patients initiating continuous kidney replacement therapy or intermittent hemodialysis in the Kingston Health Sciences Centre (KHSC) Intensive Care Unit (ICU). Measurements and Methods: rSO Results: Of 484 ICU patients, 26 met the screening criteria. Two declined, and 13 met at least one exclusion criteria. Eleven patients were enrolled. Eight died in ICU, one died 2 months after discharge, and one declined follow-up. Data capture rates were high: rSO Limitations: Enrollment was low due to a variety of factors, limiting our ability to evaluate long-term outcomes. Conclusion: rSO Competing Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: S.H.S. is cofounder and CSO of Kinarm (Kingston, Ontario, Canada), which commercializes the Kinarm End-Point Lab robotic technology used in the present study. S.A.S. has received speaking fees from Baxter Canada. N.A.J., R.M.H., A.G.D., P.A.N., B.Y.M.K., D.M.M., J.M., and J.G.B. have no conflicts of interest to declare. (© The Author(s) 2023.) |
فهرسة مساهمة: | Keywords: cerebral oxygenation; critical illness; kidney replacement therapy; neurocognitive impairment; neuroimaging Local Abstract: [Publisher, French] L’insuffisance rénale aiguë (IRA) menant à une thérapie de remplacement rénal est en augmentation chez les adultes aux soins intensifs. Un séjour aux soins intensifs et la thérapie de remplacement rénal à long terme sont indépendamment liés à des déficits cognitifs aigus et prolongés ainsi qu’à des pathologies structurelles du cerveau. La faible saturation régionale du cerveau en oxygène (rSO2) pourrait être un facteur contributif. [Publisher, French] Évaluer la possibilité de tester l’association entre la rSO |
سلسلة جزيئية: | ClinicalTrials.gov NCT04722939 |
تواريخ الأحداث: | Date Created: 20230830 Latest Revision: 20230918 |
رمز التحديث: | 20230919 |
مُعرف محوري في PubMed: | PMC10461308 |
DOI: | 10.1177/20543581231192743 |
PMID: | 37644980 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2054-3581 |
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DOI: | 10.1177/20543581231192743 |