دورية أكاديمية
Changes in Left Ventricular Global Longitudinal Strain in Patients With Heart Failure and Secondary Mitral Regurgitation: The COAPT Trial.
العنوان: | Changes in Left Ventricular Global Longitudinal Strain in Patients With Heart Failure and Secondary Mitral Regurgitation: The COAPT Trial. |
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المؤلفون: | Pio SM; Department of Cardiology Leiden University Medical Center Leiden the Netherlands., Medvedofsky D; MedStar Health Research Institute Washington DC USA., Stassen J; Department of Cardiology Leiden University Medical Center Leiden the Netherlands.; Department of Cardiology Jessa Hospital Hasselt Belgium., Delgado V; Department of Cardiology Leiden University Medical Center Leiden the Netherlands.; Hospital University Germans Trias i Pujol Badalona Spain., Namazi F; Department of Cardiology Leiden University Medical Center Leiden the Netherlands., Weissman NJ; MedStar Health Research Institute Washington DC USA., Grayburn P; Baylor Scott & White Health Plano TX., Kar S; Los Robles Regional Medical Center Thousand Oaks CA.; Bakersfield Heart Hospital Bakersfield CA., Lim DS; University of Virginia Charlottesville VA., Zhou Z; Cardiovascular Research Foundation New York NY., Alu MC; Cardiovascular Research Foundation New York NY., Redfors B; Cardiovascular Research Foundation New York NY.; Department of Cardiology Sahlgrenska University Hospital Gothenburg Sweden., Kapadia S; Cleveland Clinic Cleveland OH., Lindenfeld J; Vanderbilt University Medical Center Nashville TN., Abraham WT; Ohio State University Medical Center Columbus OH., Mack MJ; Baylor Scott & White Health Plano TX., Asch FM; MedStar Health Research Institute Washington DC USA., Stone GW; The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai New York NY., Bax JJ; Department of Cardiology Leiden University Medical Center Leiden the Netherlands.; Turku Heart Center, University of Turku and Turku University Hospital Turku Finland. |
المصدر: | Journal of the American Heart Association [J Am Heart Assoc] 2023 Sep 05; Vol. 12 (17), pp. e029956. Date of Electronic Publication: 2023 Aug 30. |
نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Oxford : Wiley-Blackwell |
مواضيع طبية MeSH: | Heart Failure*/therapy , Mitral Valve Insufficiency*/diagnostic imaging , Mitral Valve Insufficiency*/etiology , Mitral Valve Insufficiency*/surgery, Humans ; Global Longitudinal Strain ; Hospitalization ; Outcome Assessment, Health Care |
مستخلص: | Background Left ventricular (LV) global longitudinal strain (GLS) provides incremental prognostic information over LV ejection fraction in patients with heart failure (HF) and secondary mitral regurgitation. We examined the prognostic impact of LV GLS improvement in this population. Methods and Results The COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation) trial randomized symptomatic patients with HF with severe (3+/4+) mitral regurgitation to transcatheter edge-to-edge repair with the MitraClip device plus maximally tolerated guideline-directed medical therapy (GDMT) versus GDMT alone. LV GLS was measured at baseline and 6-month follow-up. The relationship between the improvement in LV GLS from baseline to 6 months and the composite of all-cause death or HF hospitalization between 6- and 24-month follow-up were assessed. Among 383 patients, 174 (45.4%) had improved LV GLS at 6-month follow-up (83/195 [42.6%] with transcatheter edge-to-edge repair+GDMT and 91/188 [48.4%] with GDMT alone; P =0.25). Improvement in LV GLS was strongly associated with reduced death or HF hospitalization between 6 and 24 months ( P <0.009), with similar risk reduction in both treatment arms ( P |
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فهرسة مساهمة: | Keywords: COAPT trial; heart failure; left ventricular global longitudinal strain; secondary mitral regurgitation; transcatheter edge‐to‐edge repair |
سلسلة جزيئية: | ClinicalTrials.gov NCT01626079 |
تواريخ الأحداث: | Date Created: 20230830 Date Completed: 20230906 Latest Revision: 20231005 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC10547326 |
DOI: | 10.1161/JAHA.122.029956 |
PMID: | 37646214 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2047-9980 |
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DOI: | 10.1161/JAHA.122.029956 |