دورية أكاديمية
Hippocampal functional connectivity mediates the association between cardiorespiratory fitness and cognitive function in healthy young adults.
| العنوان: | Hippocampal functional connectivity mediates the association between cardiorespiratory fitness and cognitive function in healthy young adults. |
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| المؤلفون: | Won J; Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, USA.; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Kinesiology, University of Maryland, College Park, MD, USA., Callow DD; Department of Kinesiology, University of Maryland, College Park, MD, USA.; Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD, USA., Purcell JJ; Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD, USA., Smith JC; Department of Kinesiology, University of Maryland, College Park, MD, USA.; Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD, USA. |
| المصدر: | Journal of the International Neuropsychological Society : JINS [J Int Neuropsychol Soc] 2024 Mar; Vol. 30 (3), pp. 199-208. Date of Electronic Publication: 2023 Aug 30. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cambridge University Press Country of Publication: England NLM ID: 9503760 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7661 (Electronic) Linking ISSN: 13556177 NLM ISO Abbreviation: J Int Neuropsychol Soc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge : Cambridge University Press Original Publication: New York, NY : Cambridge University Press, |
| مواضيع طبية MeSH: | Cardiorespiratory Fitness*/physiology, Humans ; Young Adult ; Hippocampus ; Cognition/physiology ; Temporal Lobe ; Brain ; Magnetic Resonance Imaging |
| مستخلص: | Objective: Higher cardiorespiratory fitness (CRF) induces neuroprotective effects in the hippocampus, a key brain region for memory and learning. We investigated the association between CRF and functional connectivity (FC) of the hippocampus in healthy young adults. We also examined the association between hippocampal FC and neurocognitive function. Lastly, we tested whether hippocampal FC mediates the association between 2-Min Walk Test (2MWT) and neurocognitive function. Methods: 913 young adults (28.7 ± 3.7 years) from the Human Connectome Project were included in the analyses. The 2MWT performance result was used as a proxy for cardiovascular endurance. Fluid and crystalized composite neurocognitive scores were used to assess cognition. Resting-state functional MRI data were processed to measure hippocampal FC. Linear regression was used to examine the association between 2MWT, hippocampal FC, and neurocognitive outcomes after controlling for age, sex, years of education, body mass index, systolic blood pressure, and gait speed. Results: Better 2MWT performance was associated with greater FC between the anterior hippocampus and right posterior cingulate and left middle temporal gyrus. No associations between 2MWT and posterior hippocampal FC, whole hippocampal FC, and caudate FC (control region) were observed. Greater anterior hippocampal FC was associated with better crystalized cognition scores. Lastly, greater FC between the anterior hippocampus and right posterior cingulate mediated the association between better 2MWT scores and higher crystalized cognition scores. Conclusions: Anterior hippocampal FC may be one underlying neurophysiological mechanism that promotes the association between 2MWT performance and crystalized composite cognitive function in healthy young adults. |
| معلومات مُعتمدة: | U54 MH091657 United States MH NIMH NIH HHS |
| فهرسة مساهمة: | Keywords: 2-Minute Walk Test; anterior hippocampus; cardiorespiratory fitness; functional connectivity; hippocampus; neurocognitive function; physical activity; posterior hippocampus; young adults |
| تواريخ الأحداث: | Date Created: 20230830 Date Completed: 20240305 Latest Revision: 20240611 |
| رمز التحديث: | 20240611 |
| DOI: | 10.1017/S1355617723000498 |
| PMID: | 37646336 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1469-7661 |
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| DOI: | 10.1017/S1355617723000498 |