دورية أكاديمية
Cognitive comorbidities of experimental absence seizures are independent of anxiety.
| العنوان: | Cognitive comorbidities of experimental absence seizures are independent of anxiety. |
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| المؤلفون: | Neuparth-Sottomayor M; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Lisbon, Portugal; Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Pina CC; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Lisbon, Portugal; Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Morais TP; School of Psychology, Cardiff University, Cardiff, United Kingdom; Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, United Kingdom., Farinha-Ferreira M; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Lisbon, Portugal; Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Abreu DS; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Lisbon, Portugal; Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Solano F; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Lisbon, Portugal; Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Mouro F; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Lisbon, Portugal; Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Good M; School of Psychology, Cardiff University, Cardiff, United Kingdom., Sebastião AM; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Lisbon, Portugal; Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Di Giovanni G; Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, United Kingdom; Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta., Crunelli V; Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, United Kingdom., Vaz SH; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Lisbon, Portugal; Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal. Electronic address: svaz@medicina.ulisboa.pt. |
| المصدر: | Neurobiology of disease [Neurobiol Dis] 2023 Oct 01; Vol. 186, pp. 106275. Date of Electronic Publication: 2023 Aug 28. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: San Diego, CA : Academic Press Original Publication: Oxford : Blackwell Science, c1994- |
| مواضيع طبية MeSH: | Anxiety* , Seizures*, Humans ; Child ; Adolescent ; Rats ; Animals ; Rats, Wistar ; Cognition ; Memory Disorders |
| مستخلص: | Typical absence seizures (ASs) are brief periods of lack of consciousness, associated with 2.5-4 Hz spike-wave discharges (SWDs) in the EEG, which are highly prevalent in children and teenagers. The majority of probands in these young epileptic cohorts show neuropsychological comorbidities, including cognitive, memory and mood impairments, even after the seizures are pharmacologically controlled. Similar cognition and memory deficits have been reported in different, but not all, genetic animal models of ASs. However, since these impairments are subtle and highly task-specific their presence may be confounded by an anxiety-like phenotype and no study has tested anxiety and memory in the same animals. Moreover, the majority of studies used non-epileptic inbred animals as the only control strain and this may have contributed to a misinterpretation of these behavioural results. To overcome these issues, here we used a battery of behavioural tests to compare anxiety and memory in the same animals from the well-established inbred model of Genetic Absence Epilepsy Rats from Strasbourg (GAERS), their inbred strain of Non-Epileptic Control (NEC) strain (that lack ASs) and normal outbred Wistar rats. We found that GAERS do not exhibit increased anxiety-like behavior and neophobia compared to both NEC and Wistar rats. In contrast, GAERS show decreased spontaneous alternation, spatial working memory and cross-modal object recognition compared to both NEC and Wistar rats. Furthermore, GAERS preferentially used egocentric strategies to perform spatial memory tasks. In summary, these results provide solid evidence of memory deficits in GAERS rats that do not depend on an anxiety or neophobic phenotype. Moreover, the presence of differences between NEC and Wistar rats stresses the need of using both outbred and inbred control rats in behavioural studies involving genetic models of ASs. Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Absence seizures; Anxiety; Attention deficits; GAERS; Memory impairment; NEC; Neuropsychological comorbidities; Wistar |
| تواريخ الأحداث: | Date Created: 20230830 Date Completed: 20230922 Latest Revision: 20231002 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.nbd.2023.106275 |
| PMID: | 37648038 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1095-953X |
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| DOI: | 10.1016/j.nbd.2023.106275 |