دورية أكاديمية
أعرض في EDS

Developmental dynamics of homoarginine, ADMA and SDMA plasma levels from birth to adolescence.

التفاصيل البيبلوغرافية
العنوان: Developmental dynamics of homoarginine, ADMA and SDMA plasma levels from birth to adolescence.
المؤلفون: Baach F; Department of Paediatrics, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Meyer B; Department of Paediatrics, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Oh J; Department of Paediatrics, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Lezius S; Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Böger R; Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schwedhelm E; Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; German Centre for Cardiovascular Research (DZHK E.V.), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany., Choe CU; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Neurology, Klinikum Itzehoe, Robert-Koch-Strasse 2, 25524, Itzehoe, Germany., Neu A; Department of Paediatrics, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany. axel@enp.org.; VAMED Klinik Geesthacht, Johannes-Ritter-Strasse 100, 21502, Geesthacht, Germany. axel@enp.org.
المصدر: Amino acids [Amino Acids] 2023 Oct; Vol. 55 (10), pp. 1381-1388. Date of Electronic Publication: 2023 Aug 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 9200312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1438-2199 (Electronic) Linking ISSN: 09394451 NLM ISO Abbreviation: Amino Acids Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Wien ; New York : Springer-Verlag, c1991-
مواضيع طبية MeSH: Cardiovascular Diseases* , Renal Insufficiency, Chronic*, Adult ; Infant, Newborn ; Humans ; Adolescent ; Child ; Infant ; Child, Preschool ; Homoarginine ; Arginine ; Heart
مستخلص: Guanidino compounds such as dimethylarginines (SDMA, ADMA) and L-homoarginine ((L-)hArg) can interfere with bioavailability and function of the main NO-donor L-arginine (L-Arg). High ADMA and SDMA but low L-hArg concentrations have been associated with cardio- and cerebrovascular events and mortality in adults. The role of guanidino compounds in paediatric patients remains less clear. We, therefore, compared guanidino compound levels in plasma samples of 57 individuals with chronic kidney disease (CKD) and 141 individuals without CKD from the age of 0 to 17 years, including patients with different comorbidities by correlation and regression analyses. We found highest hArg, SDMA and ADMA concentrations in neonates (Kruskal-Wallis, p < 0.001 for all). From the age of 1 year on, hArg levels increased, whereas SDMA und ADMA levels further decreased in children. SDMA and ADMA are higher in children with CKD independent of GFR (mean factor 1.92 and 1.38, respectively, p < 0.001 for both), and SDMA is strongly correlated with creatinine concentration in children with CKD (Spearman's rho 0.74, p < 0.001). We provide guanidino compound levels in a large sample covering all paediatric age groups for the first time. Our data can be used to assess the role of guanidino compounds such as hArg in disease states, i.e. cerebro- and cardiovascular disorders in childhood and adolescence.
(© 2023. The Author(s).)
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معلومات مُعتمدة: 2018-EKES.04 Else Kröner-Fresenius-Stiftung
فهرسة مساهمة: Keywords: Guanidino compound; L-arginine; Paediatric
المشرفين على المادة: 156-86-5 (Homoarginine)
94ZLA3W45F (Arginine)
تواريخ الأحداث: Date Created: 20230830 Date Completed: 20231204 Latest Revision: 20231205
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10689515
DOI: 10.1007/s00726-023-03318-w
PMID: 37648945
قاعدة البيانات: MEDLINE
الوصف
تدمد:1438-2199
DOI:10.1007/s00726-023-03318-w