Personalized chronic adaptive deep brain stimulation outperforms conventional stimulation in Parkinson's disease.
| العنوان: | Personalized chronic adaptive deep brain stimulation outperforms conventional stimulation in Parkinson's disease. |
|---|---|
| المؤلفون: | Oehrn CR; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Cernera S; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Hammer LH; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Shcherbakova M; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Yao J; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.; University of California, Berkeley - University of California, San Francisco Graduate Program in Bioengineering, Berkeley, CA, USA., Hahn A; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Wang S; Department of Neurology, University of California, San Francisco, San Francisco, California, USA.; Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Ostrem JL; Department of Neurology, University of California, San Francisco, San Francisco, California, USA.; Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Little S; Department of Neurology, University of California, San Francisco, San Francisco, California, USA.; University of California, Berkeley - University of California, San Francisco Graduate Program in Bioengineering, Berkeley, CA, USA.; Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Starr PA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.; University of California, Berkeley - University of California, San Francisco Graduate Program in Bioengineering, Berkeley, CA, USA.; Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. |
| المصدر: | MedRxiv : the preprint server for health sciences [medRxiv] 2023 Aug 08. Date of Electronic Publication: 2023 Aug 08. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | Deep brain stimulation is a widely used therapy for Parkinson's disease (PD) but currently lacks dynamic responsiveness to changing clinical and neural states. Feedback control has the potential to improve therapeutic effectiveness, but optimal control strategy and additional benefits of "adaptive" neurostimulation are unclear. We implemented adaptive subthalamic nucleus stimulation, controlled by subthalamic or cortical signals, in three PD patients (five hemispheres) during normal daily life. We identified neurophysiological biomarkers of residual motor fluctuations using data-driven analyses of field potentials over a wide frequency range and varying stimulation amplitudes. Narrowband gamma oscillations (65-70 Hz) at either site emerged as the best control signal for sensing during stimulation. A blinded, randomized trial demonstrated improved motor symptoms and quality of life compared to clinically optimized standard stimulation. Our approach highlights the promise of personalized adaptive neurostimulation based on data-driven selection of control signals and may be applied to other neurological disorders. |
| References: | J Neurosci. 1995 May;15(5 Pt 1):3526-38. (PMID: 7751928) IEEE Trans Biomed Circuits Syst. 2018 Dec;12(6):1230-1245. (PMID: 30418885) J Neurosci. 2008 Jun 11;28(24):6165-73. (PMID: 18550758) Front Neurosci. 2021 Nov 11;15:734186. (PMID: 34858126) Mov Disord. 2020 Apr;35(4):555-561. (PMID: 32039501) NPJ Parkinsons Dis. 2021 Sep 28;7(1):88. (PMID: 34584095) J Neural Eng. 2021 Nov 16;18(6):. (PMID: 34678794) Epilepsia. 2014 Mar;55(3):432-41. (PMID: 24621228) Neurobiol Dis. 2021 May;152:105287. (PMID: 33549721) Brain Stimul. 2020 Sep - Oct;13(5):1414-1415. (PMID: 32745654) IEEE Trans Neural Syst Rehabil Eng. 2012 Jul;20(4):410-21. (PMID: 22275720) Neuroimage. 2015 Feb 15;107:127-135. (PMID: 25498389) Brain Stimul. 2020 Nov - Dec;13(6):1507-1516. (PMID: 32738409) Neuroimage. 2019 Jan 1;184:293-316. (PMID: 30179717) Front Neurosci. 2018 Sep 07;12:619. (PMID: 30245616) J Neurosci. 2016 Jun 15;36(24):6445-58. (PMID: 27307233) Parkinsonism Relat Disord. 2014 Jun;20(6):578-83. (PMID: 24674770) Brain Stimul. 2020 Nov - Dec;13(6):1784-1792. (PMID: 33038597) Front Neurosci. 2021 Dec 09;15:769872. (PMID: 34955721) PLoS One. 2015 Apr 30;10(4):e0124522. (PMID: 25928634) Arch Neurol. 2011 Feb;68(2):165. (PMID: 20937936) Expert Rev Neurother. 2022 Sep;22(9):789-803. (PMID: 36228575) N Engl J Med. 1984 Feb 23;310(8):483-8. (PMID: 6694694) Lancet Neurol. 2012 Feb;11(2):140-9. (PMID: 22239915) Brain Stimul. 2019 Jul - Aug;12(4):868-876. (PMID: 30833216) Front Hum Neurosci. 2016 Feb 03;10:10. (PMID: 26869898) Nat Biotechnol. 2021 Sep;39(9):1078-1085. (PMID: 33941932) BMJ Open. 2022 Jan 03;12(1):e049955. (PMID: 34980610) Clin Neurophysiol. 2016 Jan;127(1):277-284. (PMID: 25907415) Front Neurosci. 2021 Oct 18;15:732499. (PMID: 34733132) Neuroimage. 2018 Apr 15;170:271-282. (PMID: 28536045) Nat Med. 2021 Oct;27(10):1696-1700. (PMID: 34608328) Lancet Neurol. 2020 Jun;19(6):491-501. (PMID: 32470421) Comput Intell Neurosci. 2011;2011:156869. (PMID: 21253357) Mov Disord. 2023 Jun;38(6):937-948. (PMID: 37148553) Front Neurosci. 2021 Dec 16;15:762097. (PMID: 34975374) Lancet Neurol. 2016 Nov;15(12):1257-1272. (PMID: 27751556) Nat Rev Neurol. 2019 Mar;15(3):148-160. (PMID: 30683913) Brain. 2017 Apr 1;140(4):1053-1067. (PMID: 28334851) Qual Life Res. 2011 Dec;20(10):1727-36. (PMID: 21479777) J Neural Eng. 2018 Aug;15(4):046006. (PMID: 29741160) Mov Disord. 2007 Jan;22(1):41-7. (PMID: 17115387) Eur J Neurosci. 2006 Apr;23(7):1956-60. (PMID: 16623853) J Neurosci. 2012 Nov 21;32(47):16541-51. (PMID: 23175810) Exp Neurol. 2022 May;351:113999. (PMID: 35143832) J Neurosci. 2001 Feb 1;21(3):1033-8. (PMID: 11157088) J Neurosci Methods. 2010 Jan 15;185(2):293-8. (PMID: 19836416) J Neurol. 2019 Feb;266(2):289-297. (PMID: 29909467) N Engl J Med. 2006 Aug 31;355(9):896-908. (PMID: 16943402) J Neural Eng. 2022 Mar 31;19(2):. (PMID: 35234664) J Neurosci Methods. 2007 Aug 15;164(1):177-90. (PMID: 17517438) Stereotact Funct Neurosurg. 2022;100(3):168-183. (PMID: 35130555) Handb Clin Neurol. 2022;184:259-271. (PMID: 35034740) Neurology. 2018 Mar 13;90(11):e971-e976. (PMID: 29444973) Brain Stimul. 2021 Nov-Dec;14(6):1434-1443. (PMID: 34547503) Curr Biol. 2018 Sep 24;28(18):3016-3022.e4. (PMID: 30197086) Brain Stimul. 2021 Sep-Oct;14(5):1301-1306. (PMID: 34428554) Ann Neurol. 2013 Sep;74(3):449-57. (PMID: 23852650) NPJ Parkinsons Dis. 2022 Apr 19;8(1):44. (PMID: 35440571) Exp Neurol. 2022 May;351:113993. (PMID: 35104499) JAMA. 2009 Jan 7;301(1):63-73. (PMID: 19126811) J Neural Eng. 2021 Aug 31;18(4):. (PMID: 34388744) Front Hum Neurosci. 2021 Aug 13;15:702961. (PMID: 34483867) |
| معلومات مُعتمدة: | R25 NS070680 United States NS NINDS NIH HHS; K23 NS120037 United States NS NINDS NIH HHS; F32 NS129627 United States NS NINDS NIH HHS; R01 NS131405 United States NS NINDS NIH HHS; UH3 NS100544 United States NS NINDS NIH HHS |
| تواريخ الأحداث: | Date Created: 20230831 Latest Revision: 20230907 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10463549 |
| DOI: | 10.1101/2023.08.03.23293450 |
| PMID: | 37649907 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2023.08.03.23293450 |
|---|