دورية أكاديمية
Mitophagy-promoting agents and their ability to promote healthy-aging.
| العنوان: | Mitophagy-promoting agents and their ability to promote healthy-aging. |
|---|---|
| المؤلفون: | Srivastava V; Faculty of Medicine, IMRIC Department of Biochemistry and Molecular Biology, The Hebrew University of Jerusalem, PO Box 12271, Jerusalem, Israel., Gross E; Faculty of Medicine, IMRIC Department of Biochemistry and Molecular Biology, The Hebrew University of Jerusalem, PO Box 12271, Jerusalem, Israel. |
| المصدر: | Biochemical Society transactions [Biochem Soc Trans] 2023 Oct 31; Vol. 51 (5), pp. 1811-1846. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Portland Press On The Behalf Of The Biochemical Society Country of Publication: England NLM ID: 7506897 Publication Model: Print Cited Medium: Internet ISSN: 1470-8752 (Electronic) Linking ISSN: 03005127 NLM ISO Abbreviation: Biochem Soc Trans Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Portland Press On The Behalf Of The Biochemical Society |
| مواضيع طبية MeSH: | Mitophagy* , Autophagy*, Animals ; Humans ; Mitochondria ; Aging ; Longevity |
| مستخلص: | The removal of damaged mitochondrial components through a process called mitochondrial autophagy (mitophagy) is essential for the proper function of the mitochondrial network. Hence, mitophagy is vital for the health of all aerobic animals, including humans. Unfortunately, mitophagy declines with age. Many age-associated diseases, including Alzheimer's and Parkinson's, are characterized by the accumulation of damaged mitochondria and oxidative damage. Therefore, activating the mitophagy process with small molecules is an emerging strategy for treating multiple aging diseases. Recent studies have identified natural and synthetic compounds that promote mitophagy and lifespan. This article aims to summarize the existing knowledge about these substances. For readers' convenience, the knowledge is presented in a table that indicates the chemical data of each substance and its effect on lifespan. The impact on healthspan and the molecular mechanism is reported if known. The article explores the potential of utilizing a combination of mitophagy-inducing drugs within a therapeutic framework and addresses the associated challenges of this strategy. Finally, we discuss the process that balances mitophagy, i.e. mitochondrial biogenesis. In this process, new mitochondrial components are generated to replace the ones cleared by mitophagy. Furthermore, some mitophagy-inducing substances activate biogenesis (e.g. resveratrol and metformin). Finally, we discuss the possibility of combining mitophagy and biogenesis enhancers for future treatment. In conclusion, this article provides an up-to-date source of information about natural and synthetic substances that activate mitophagy and, hopefully, stimulates new hypotheses and studies that promote healthy human aging worldwide. (© 2023 The Author(s).) |
| References: | Cell Calcium. 2011 Sep;50(3):242-50. (PMID: 21571367) Nat Med. 2016 Aug;22(8):879-88. (PMID: 27400265) Antioxidants (Basel). 2021 Mar 12;10(3):. (PMID: 33809299) Rejuvenation Res. 2021 Jun;24(3):198-205. (PMID: 33115330) Int J Mol Sci. 2020 Apr 08;21(7):. (PMID: 32276415) Mech Ageing Dev. 2009 Jul;130(7):461-5. (PMID: 19442682) Cell Metab. 2012 May 2;15(5):713-24. (PMID: 22560223) Age (Dordr). 2015;37(2):31. (PMID: 25833406) Front Neurol. 2022 Feb 14;12:646817. (PMID: 35237220) Br J Pharmacol. 2007 Aug;151(8):1154-65. (PMID: 17519949) Aging Cell. 2017 Apr;16(2):401-413. (PMID: 28054425) Cell Death Dis. 2010;1:e10. (PMID: 21364612) Int J Biomed Sci. 2006 Dec;2(4):402-5. (PMID: 23675008) FASEB J. 2021 May;35(5):e21537. (PMID: 33817834) Nature. 2003 Sep 11;425(6954):191-6. (PMID: 12939617) Mol Metab. 2013 Feb 14;2(2):92-102. (PMID: 24199155) Food Funct. 2020 Jun 24;11(6):5621-5634. (PMID: 32530444) Age (Dordr). 2014 Jun;36(3):9628. (PMID: 24535708) Nat Commun. 2013;4:2192. (PMID: 23900241) PLoS Pathog. 2020 May 28;16(5):e1008470. (PMID: 32463825) Aging Cell. 2014 Apr;13(2):206-15. (PMID: 24134630) Cancer Cell Int. 2021 Jul 5;21(1):350. (PMID: 34225732) Eur J Nutr. 2011 Aug;50(5):387-9. (PMID: 21301855) Cell Calcium. 2012 Jul;52(1):44-51. (PMID: 22459281) Biochem Soc Trans. 2020 Apr 29;48(2):709-717. (PMID: 32129826) Cell Death Dis. 2022 Nov 5;13(11):928. (PMID: 36335091) PLoS Biol. 2009 Nov;7(11):e1000245. (PMID: 19924292) EMBO J. 2005 Nov 16;24(22):3846-58. (PMID: 16237459) Exp Gerontol. 2013 May;48(5):499-506. (PMID: 23485446) Antioxid Redox Signal. 2011 Dec 15;15(12):3003-19. (PMID: 21545274) J Gerontol A Biol Sci Med Sci. 2014 Jul;69(7):810-20. (PMID: 24398558) WormBook. 2013 Dec 26;:1-43. (PMID: 24395814) Geroscience. 2022 Jun;44(3):1505-1524. (PMID: 35445360) J Neurosci Res. 2010 Mar;88(4):896-904. (PMID: 19798750) Adv Gerontol. 2013;26(1):111-6. (PMID: 24003736) PLoS One. 2020 Nov 5;15(11):e0241122. (PMID: 33151963) Cell Cycle. 2008 Sep 1;7(17):2769-73. (PMID: 18728386) Front Genet. 2018 May 04;9:160. (PMID: 29780405) Autophagy. 2018;14(10):1665-1673. (PMID: 29895192) PLoS Comput Biol. 2023 Mar 23;19(3):e1010200. (PMID: 36952569) Neuroimage. 2018 Jul 1;174:177-190. (PMID: 29548848) J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. (PMID: 20974732) JCI Insight. 2022 Oct 24;7(20):. (PMID: 36278487) Cell Rep. 2016 Apr 19;15(3):638-650. (PMID: 27068460) J Agric Food Chem. 2013 Aug 14;61(32):7800-4. (PMID: 23879808) Metabolites. 2022 Nov 17;12(11):. (PMID: 36422268) Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12980-5. (PMID: 15328413) JAMA Netw Open. 2022 Jan 4;5(1):e2144279. (PMID: 35050355) Arch Gerontol Geriatr. 1982 Sep;1(2):159-65. (PMID: 6821144) Mech Ageing Dev. 2012 Jan;133(1):1-10. (PMID: 22155175) Oxid Med Cell Longev. 2016;2016:6705621. (PMID: 26770656) Aging Cell. 2023 Feb;22(2):e13774. (PMID: 36670049) Sci Rep. 2017 Apr 25;7(1):1131. (PMID: 28442745) Comp Biochem Physiol C Toxicol Pharmacol. 2023 Sep;271:109676. (PMID: 37269918) Cell Metab. 2008 Aug;8(2):157-68. (PMID: 18599363) Aging (Albany NY). 2011 Feb;3(2):148-57. (PMID: 21386129) Dev Cell. 2005 Nov;9(5):605-15. (PMID: 16256736) J Biol Chem. 2008 May 16;283(20):13501-5. (PMID: 18372247) Nat Rev Drug Discov. 2009 Feb;8(2):111-28. (PMID: 19180105) Annu Rev Physiol. 2016;78:23-44. (PMID: 26474213) Mech Ageing Dev. 2011 Oct;132(10):480-7. (PMID: 21855561) Biochemistry (Mosc). 2005 Sep;70(9):986-9. (PMID: 16266268) Food Funct. 2023 Aug 14;14(16):7347-7360. (PMID: 37490309) Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):E2501-9. (PMID: 24889636) Nat Neurosci. 2019 Mar;22(3):401-412. (PMID: 30742114) J Biol Chem. 2012 Jun 1;287(23):19094-104. (PMID: 22505714) Cell. 2017 Jan 12;168(1-2):224-238.e10. (PMID: 28017329) J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):6-16. (PMID: 22451473) Nat Cell Biol. 2012 Jan 22;14(2):177-85. (PMID: 22267086) J Biol Chem. 2006 May 5;281(18):12580-6. (PMID: 16407196) Aging Cell. 2022 Apr;21(4):e13583. (PMID: 35263007) FASEB J. 1999 Aug;13(11):1385-93. (PMID: 10428762) Respir Res. 2019 Nov 27;20(1):264. (PMID: 31775876) Neuroscience. 2010 Aug 11;169(1):23-38. (PMID: 20438809) Neurobiol Dis. 2021 Jul;154:105359. (PMID: 33798740) Food Funct. 2019 Mar 20;10(3):1398-1410. (PMID: 30758000) PLoS One. 2020 Sep 3;15(9):e0238528. (PMID: 32881908) Autophagy. 2023 Feb;19(2):474-504. (PMID: 35579620) Autophagy. 2022 Jan;18(1):24-39. (PMID: 33570005) PLoS Biol. 2010 Dec 07;8(12):e1000556. (PMID: 21151885) Int J Mol Sci. 2010 Mar 31;11(4):1321-42. (PMID: 20480022) Dev Biol. 2019 Oct 1;454(1):15-20. (PMID: 31233739) PLoS Genet. 2008 Feb;4(2):e24. (PMID: 18282106) Brain Res. 2017 May 15;1663:184-193. (PMID: 28322751) Nature. 2015 May 28;521(7553):525-8. (PMID: 25896323) PLoS One. 2011;6(11):e27762. (PMID: 22114686) Exp Gerontol. 2017 Sep;95:54-62. (PMID: 28457986) Trends Biochem Sci. 2010 Sep;35(9):505-13. (PMID: 20430626) Annu Rev Physiol. 2019 Feb 10;81:453-482. (PMID: 30485761) Aging (Albany NY). 2020 Feb 12;12(3):2840-2856. (PMID: 32074508) Exp Gerontol. 2002 May;37(5):629-38. (PMID: 11909680) Rejuvenation Res. 2010 Oct;13(5):561-70. (PMID: 20645870) Plants (Basel). 2023 Mar 07;12(6):. (PMID: 36986905) PLoS One. 2009 Jul 27;4(7):e6348. (PMID: 19633713) Cell Rep Med. 2022 May 17;3(5):100633. (PMID: 35584623) Aging Cell. 2017 Oct;16(5):1191-1194. (PMID: 28612944) Eur Rev Med Pharmacol Sci. 2022 Nov;26(21):8039-8056. (PMID: 36394755) J Gerontol A Biol Sci Med Sci. 2001 Jul;56(7):B311-23. (PMID: 11445596) Aging Cell. 2008 Aug;7(4):552-60. (PMID: 18505478) Exp Gerontol. 2014 Aug;56:182-8. (PMID: 24486129) FEBS J. 2021 Oct;288(19):5737-5754. (PMID: 33837631) Cell Metab. 2018 Mar 6;27(3):667-676.e4. (PMID: 29514072) Nature. 2015 Aug 20;524(7565):370-4. (PMID: 26161729) Front Bioeng Biotechnol. 2021 Jul 01;9:635768. (PMID: 34327192) Front Med (Lausanne). 2022 Sep 06;9:951889. (PMID: 36148467) Biol Chem. 2017 Dec 20;399(1):29-45. (PMID: 28976890) Geroscience. 2021 Apr;43(2):629-644. (PMID: 33462708) Mol Neurobiol. 2018 Mar;55(3):2085-2101. (PMID: 28283884) EBioMedicine. 2018 Oct;36:18-28. (PMID: 30279143) Alzheimers Dement. 2017 May;13(5):582-591. (PMID: 27599210) Sci Rep. 2017 Apr 11;7:46208. (PMID: 28397803) EMBO J. 2016 Aug 1;35(15):1677-93. (PMID: 27334614) Oxid Med Cell Longev. 2017;2017:9028435. (PMID: 28626500) Mol Genet Metab. 2019 Nov;128(3):198-203. (PMID: 30709775) Trends Parasitol. 2021 Jan;37(1):48-64. (PMID: 33189582) Arch Biochem Biophys. 2007 Jun 15;462(2):245-53. (PMID: 17475204) Aging (Albany NY). 2021 Apr 20;13(8):11738-11751. (PMID: 33878030) Cell. 2007 May 4;129(3):473-84. (PMID: 17482543) Int Rev Cell Mol Biol. 2018;340:169-208. (PMID: 30072091) Toxins (Basel). 2023 Mar 06;15(3):. (PMID: 36977093) EMBO Rep. 2010 Jan;11(1):45-51. (PMID: 20010802) Cannabis Cannabinoid Res. 2021 Dec;6(6):522-527. (PMID: 33998871) EMBO J. 2021 Feb 1;40(3):e104705. (PMID: 33438778) Autophagy. 2009 Aug;5(6):847-9. (PMID: 19458476) Nat Rev Mol Cell Biol. 2018 Jan 23;19(2):93-108. (PMID: 29358684) Br J Pharmacol. 2023 Jun;180(12):1542-1561. (PMID: 36792062) Elife. 2016 Aug 23;5:. (PMID: 27549339) Protein Cell. 2019 Oct;10(10):770-775. (PMID: 31325157) Nat Rev Mol Cell Biol. 2023 Mar;24(3):167-185. (PMID: 36302887) Nature. 2019 Oct;574(7778):359-364. (PMID: 31619788) Free Radic Biol Med. 2006 Dec 1;41(11):1662-9. (PMID: 17145554) Integr Biol (Camb). 2014 Jan;6(1):35-43. (PMID: 24305800) Comp Biochem Physiol B Biochem Mol Biol. 2008 Feb;149(2):314-23. (PMID: 18024103) Rejuvenation Res. 2016 Mar 15;19(5):414-422. (PMID: 26778291) Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):633-640. (PMID: 28017650) Cell. 2013 Jul 18;154(2):430-41. (PMID: 23870130) Int J Mol Sci. 2013 Jun 04;14(6):11895-914. (PMID: 23736695) J Pineal Res. 1997 Oct;23(3):123-30. (PMID: 9406982) Int J Mol Sci. 2018 Jan 11;19(1):. (PMID: 29324667) Nature. 2004 Aug 5;430(7000):686-9. (PMID: 15254550) Autophagy. 2017 Jun 3;13(6):1080-1081. (PMID: 28323531) Autophagy. 2009 Jul;5(5):690-8. (PMID: 19363302) Exp Gerontol. 2012 Dec;47(12):940-9. (PMID: 22960591) NPJ Aging Mech Dis. 2020 Jun 10;6:6. (PMID: 32566245) Biogerontology. 2011 Jun;12(3):195-209. (PMID: 21153705) Redox Biol. 2022 Jul;53:102342. (PMID: 35605453) Autophagy. 2015;11(8):1259-79. (PMID: 26114658) J Biol Chem. 2013 Jan 11;288(2):1099-113. (PMID: 23209295) Cell Metab. 2010 Jan;11(1):35-46. (PMID: 20074526) Oxid Med Cell Longev. 2019 Jun 24;2019:5958043. (PMID: 31341531) Exp Gerontol. 2013 Feb;48(2):229-39. (PMID: 23063786) PLoS One. 2014 Nov 11;9(11):e112825. (PMID: 25386805) Aging Cell. 2013 Jun;12(3):508-17. (PMID: 23534459) Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt A):1115-1128. (PMID: 29366775) Cell Metab. 2016 Oct 11;24(4):566-581. (PMID: 27732836) FEMS Yeast Res. 2019 Jan 1;19(1):. (PMID: 30312390) Nat Cell Biol. 2009 Nov;11(11):1305-14. (PMID: 19801973) Cell. 2013 Mar 28;153(1):228-39. (PMID: 23540700) Cell Death Dis. 2019 Sep 10;10(9):653. (PMID: 31506428) Circ Res. 2016 May 13;118(10):1563-76. (PMID: 27174950) Nat Med. 2016 Dec;22(12):1428-1438. (PMID: 27841876) Front Pharmacol. 2023 Jun 06;14:1195490. (PMID: 37346299) Int J Food Sci Nutr. 2022 Mar;73(2):274-283. (PMID: 34551650) J Appl Physiol (1985). 2006 Dec;101(6):1685-92. (PMID: 16902066) Genes Dev. 2006 Jan 15;20(2):174-84. (PMID: 16418483) Mech Ageing Dev. 2021 Sep;198:111518. (PMID: 34139214) Genetics. 2007 Jul;176(3):1567-77. (PMID: 17483415) Biogerontology. 2020 Feb;21(1):109-123. (PMID: 31659616) Biochem Biophys Res Commun. 2019 Aug 13;516(1):202-208. (PMID: 31204051) J Gerontol A Biol Sci Med Sci. 2020 Oct 15;75(11):2042-2050. (PMID: 32361753) Cells. 2022 Aug 27;11(17):. (PMID: 36078067) Oxid Med Cell Longev. 2020 Jul 31;2020:6069354. (PMID: 32832002) J Agric Food Chem. 2013 Mar 6;61(9):2158-64. (PMID: 23339711) Nature. 2015 Aug 20;524(7565):309-314. (PMID: 26266977) Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9082-7. (PMID: 10922063) Curr Neuropharmacol. 2021;19(2):170-192. (PMID: 32442087) J Pharm Pharmacol. 2023 Aug 1;75(8):1066-1075. (PMID: 37203217) Front Chem. 2022 Jun 08;10:918116. (PMID: 35755259) FEBS Lett. 2004 Jan 30;558(1-3):3-6. (PMID: 14982062) J Biol Chem. 2004 Nov 26;279(48):49883-8. (PMID: 15383542) Mol Neurobiol. 2017 Apr;54(3):1661-1676. (PMID: 26873850) Nat Commun. 2013;4:2267. (PMID: 23925298) Circ Res. 2012 Oct 12;111(9):1208-21. (PMID: 23065344) Mol Cell. 2019 Mar 7;73(5):1028-1043.e5. (PMID: 30733118) Biochim Biophys Acta. 2016 Apr;1860(4):727-45. (PMID: 26802309) Cell Mol Life Sci. 2021 Apr;78(8):3817-3851. (PMID: 33580835) Toxicol Pathol. 2003 Nov-Dec;31(6):589-603. (PMID: 14585727) Br J Pharmacol. 2014 May;171(9):2351-63. (PMID: 24428821) Nat Metab. 2021 Jan;3(1):33-42. (PMID: 33462515) Front Pharmacol. 2017 Dec 07;8:884. (PMID: 29375370) Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23760-23771. (PMID: 31676548) Cannabis Cannabinoid Res. 2023 May 9;:. (PMID: 37158809) Aging Cell. 2019 Dec;18(6):e13039. (PMID: 31557380) J Biol Chem. 2008 Jan 4;283(1):350-357. (PMID: 17959600) J Gerontol A Biol Sci Med Sci. 2023 Jul 8;78(7):1100-1107. (PMID: 36941756) Comp Biochem Physiol C Toxicol Pharmacol. 2021 Apr;242:108944. (PMID: 33278594) Biogerontology. 2018 Apr;19(2):145-157. (PMID: 29340835) Int J Mol Sci. 2021 Apr 09;22(8):. (PMID: 33918863) J Agric Food Chem. 2007 Mar 21;55(6):2446-51. (PMID: 17323973) Geroscience. 2020 Jun;42(3):937-949. (PMID: 32285289) Aging Cell. 2008 Oct;7(5):641-50. (PMID: 18631321) Theranostics. 2023 Jan 1;13(2):736-766. (PMID: 36632220) J Neurosci. 2019 Mar 27;39(13):2369-2382. (PMID: 30692222) Nature. 2006 May 25;441(7092):437-43. (PMID: 16724055) |
| فهرسة مساهمة: | Keywords: aging; lifespan; mitochondria; mitochondrial autophagy; mitochondrial biogenesis; mitophagy |
| تواريخ الأحداث: | Date Created: 20230831 Date Completed: 20231101 Latest Revision: 20231121 |
| رمز التحديث: | 20231121 |
| مُعرف محوري في PubMed: | PMC10657188 |
| DOI: | 10.1042/BST20221363 |
| PMID: | 37650304 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1470-8752 |
|---|---|
| DOI: | 10.1042/BST20221363 |