دورية أكاديمية
Mitophagy-promoting agents and their ability to promote healthy-aging.
العنوان: | Mitophagy-promoting agents and their ability to promote healthy-aging. |
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المؤلفون: | Srivastava V; Faculty of Medicine, IMRIC Department of Biochemistry and Molecular Biology, The Hebrew University of Jerusalem, PO Box 12271, Jerusalem, Israel., Gross E; Faculty of Medicine, IMRIC Department of Biochemistry and Molecular Biology, The Hebrew University of Jerusalem, PO Box 12271, Jerusalem, Israel. |
المصدر: | Biochemical Society transactions [Biochem Soc Trans] 2023 Oct 31; Vol. 51 (5), pp. 1811-1846. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Portland Press On The Behalf Of The Biochemical Society Country of Publication: England NLM ID: 7506897 Publication Model: Print Cited Medium: Internet ISSN: 1470-8752 (Electronic) Linking ISSN: 03005127 NLM ISO Abbreviation: Biochem Soc Trans Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Portland Press On The Behalf Of The Biochemical Society |
مواضيع طبية MeSH: | Mitophagy* , Autophagy*, Animals ; Humans ; Mitochondria ; Aging ; Longevity |
مستخلص: | The removal of damaged mitochondrial components through a process called mitochondrial autophagy (mitophagy) is essential for the proper function of the mitochondrial network. Hence, mitophagy is vital for the health of all aerobic animals, including humans. Unfortunately, mitophagy declines with age. Many age-associated diseases, including Alzheimer's and Parkinson's, are characterized by the accumulation of damaged mitochondria and oxidative damage. Therefore, activating the mitophagy process with small molecules is an emerging strategy for treating multiple aging diseases. Recent studies have identified natural and synthetic compounds that promote mitophagy and lifespan. This article aims to summarize the existing knowledge about these substances. For readers' convenience, the knowledge is presented in a table that indicates the chemical data of each substance and its effect on lifespan. The impact on healthspan and the molecular mechanism is reported if known. The article explores the potential of utilizing a combination of mitophagy-inducing drugs within a therapeutic framework and addresses the associated challenges of this strategy. Finally, we discuss the process that balances mitophagy, i.e. mitochondrial biogenesis. In this process, new mitochondrial components are generated to replace the ones cleared by mitophagy. Furthermore, some mitophagy-inducing substances activate biogenesis (e.g. resveratrol and metformin). Finally, we discuss the possibility of combining mitophagy and biogenesis enhancers for future treatment. In conclusion, this article provides an up-to-date source of information about natural and synthetic substances that activate mitophagy and, hopefully, stimulates new hypotheses and studies that promote healthy human aging worldwide. (© 2023 The Author(s).) |
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فهرسة مساهمة: | Keywords: aging; lifespan; mitochondria; mitochondrial autophagy; mitochondrial biogenesis; mitophagy |
تواريخ الأحداث: | Date Created: 20230831 Date Completed: 20231101 Latest Revision: 20231121 |
رمز التحديث: | 20231121 |
مُعرف محوري في PubMed: | PMC10657188 |
DOI: | 10.1042/BST20221363 |
PMID: | 37650304 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1470-8752 |
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DOI: | 10.1042/BST20221363 |