دورية أكاديمية
Real-world study on microsatellite instability and mismatch repair deficiency testing patterns among patients with metastatic colorectal cancer in Spain.
العنوان: | Real-world study on microsatellite instability and mismatch repair deficiency testing patterns among patients with metastatic colorectal cancer in Spain. |
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المؤلفون: | Garcia-Carbonero R; Medical Oncology Department, Hospital Universitario 12 de Octubre, IIS Imas12, UCM, Av Cordoba S/N, 28041, Madrid, Spain. rgcarbonero@gmail.com., González Astorga B; Medical Oncology Department, Hospital Universitario Clínico San Cecilio, Granada, Spain., Vidal Tocino R; Medical Oncology Department, Complejo Asistencial Universitario de Salamanca, IBSAL, Salamanca, Spain., Contreras Toledo D; Medical Oncology Department, Hospital Universitario Central de Asturias, ISPA, Programa Doctorado en Ciencias de la Salud, Universidad de Oviedo, Oviedo, Spain., Pericay C; Medical Oncology Department, Hospital Universitari Parc Taulí, Sabadell, Spain., Fernández Montes A; Medical Oncology Department, Complexo Hospitalario Universitario de Ourense, Ourense, Spain., Falcó E; Medical Oncology Department, Hospital Son Llatzer, Palma, Spain., González Cordero M; Medical Oncology Department, Hospital Universitario de Badajoz, Badajoz, Spain., Reina Zoilo JJ; Medical Oncology Department, Hospital Universitario Virgen Macarena, Sevilla, Spain., Alonso V; Medical Oncology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain., Rodríguez Salas N; Medical Oncology Department, Hospital Universitario La Paz, Madrid, Spain., Gil-Raga M; Medical Oncology Department, Hospital General Universitario de Valencia, Valencia, Spain., Santos C; Medical Oncology Department, Institute Català d'Oncologia IDIBELL, L'Hospitalet, Barcelona, Spain., Páez D; Medical Oncology Department, U705 (CIBERER), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Anton-Pascual B; Medical Oncology Department, Hospital Universitario 12 de Octubre, IIS Imas12, UCM, Av Cordoba S/N, 28041, Madrid, Spain., Aguilar F; Medical Affairs Department, MSD Spain, C/Josefa Valcarcel, 38, 28027, Madrid, Spain. fernando.aguilar@merck.com., Morales P; Medical Affairs Department, MSD Spain, C/Josefa Valcarcel, 38, 28027, Madrid, Spain. |
المصدر: | Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2024 Apr; Vol. 26 (4), pp. 864-871. Date of Electronic Publication: 2023 Aug 31. |
نوع المنشور: | Journal Article; Multicenter Study; Observational Study |
اللغة: | English |
بيانات الدورية: | Publisher: Country of Publication: Italy NLM ID: 101247119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1699-3055 (Electronic) Linking ISSN: 1699048X NLM ISO Abbreviation: Clin Transl Oncol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2010- >: Milan : Springer Italia Original Publication: Barcelona, Spain : Doyma, c2005- |
مواضيع طبية MeSH: | Brain Neoplasms* , Colonic Neoplasms*/pathology , Colorectal Neoplasms*/diagnosis , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/drug therapy , Neoplastic Syndromes, Hereditary* , Rectal Neoplasms*, Aged ; Humans ; Microsatellite Instability ; Retrospective Studies ; Spain |
مستخلص: | Purpose: Clinical practice guidelines recommend that all patients with metastatic colorectal cancer (mCRC) should be tested for mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H). We aimed to describe the dMMR/MSI-H testing practice in patients with mCRC in Spanish centers. Methods: Multicenter, observational retrospective study that included patients newly diagnosed with mCRC or who progressed to a metastatic stage from early/localized stages. Results: Three hundred patients were included in the study from May 2020 through May 2021, with a median age of 68 years, and two hundred twenty-five (75%) had stage IV disease at initial diagnosis; two hundred eighty-four patients received first-line treatment, and dMMR/MSI-H testing was performed in two hundred fifty-one (84%) patients. The results of the dMMR/MSI-H tests were available in 61 (24%) of 251 patients before the diagnosis of metastatic disease and in 191 (81%) of 236 evaluable patients for this outcome before the initiation of first-line treatment. Among the 244 patients who were tested for dMMR/MSI-H with IHC or PCR, 14 (6%) were MMR deficient. The most frequent type of first-line treatment was the combination of chemotherapy and biological agent, that was received by 71% and 50% of patients with MMR proficient and deficient tumors, respectively, followed by chemotherapy alone, received in over 20% of patients in each subgroup. Only 29% of dMMR/MSI-H tumors received first-line immunotherapy. Conclusion: Our study suggests that a high proportion of patients with mCRC are currently tested for dMMR/MSI-H in tertiary hospitals across Spain. However, there is still room for improvement until universal testing is achieved. Trial Registration: Not applicable. (© 2023. The Author(s).) |
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فهرسة مساهمة: | Keywords: Metastatic colorectal cancer; Microsatellite instability; Microsatellite stable; Mismatch repair deficiency; Real-world evidence |
SCR Disease Name: | Turcot syndrome |
تواريخ الأحداث: | Date Created: 20230831 Date Completed: 20240401 Latest Revision: 20240708 |
رمز التحديث: | 20240708 |
مُعرف محوري في PubMed: | PMC10981578 |
DOI: | 10.1007/s12094-023-03309-z |
PMID: | 37651021 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1699-3055 |
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DOI: | 10.1007/s12094-023-03309-z |