دورية أكاديمية
أعرض في EDS

Polyhexamethylene guanidine hydrochloride as promising active ingredient for oral antiseptic products to eliminate microorganisms threatening the health of endangered wild cats: a comparative study with chlorhexidine digluconate.

التفاصيل البيبلوغرافية
العنوان: Polyhexamethylene guanidine hydrochloride as promising active ingredient for oral antiseptic products to eliminate microorganisms threatening the health of endangered wild cats: a comparative study with chlorhexidine digluconate.
المؤلفون: de Barros RA; Department of Postgraduate Program in Animal Science, University of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, CEP 14, Franca, SP, 404-600, Brazil., Rodrigues MA; Department of Postgraduate Program in Animal Science, University of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, CEP 14, Franca, SP, 404-600, Brazil., Ambrósio SR; Department of Postgraduate Program in Animal Science, University of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, CEP 14, Franca, SP, 404-600, Brazil., SolaVeneziani RC; Department of Postgraduate Program in Animal Science, University of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, CEP 14, Franca, SP, 404-600, Brazil., Júnior DP; Department of Postgraduate Program in Animal Science, University of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, CEP 14, Franca, SP, 404-600, Brazil., Parreira RLT; Department of Postgraduate Program in Sciences, University of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, CEP 14, Franca, SP, 404-600, Brazil., Ambrósio MALV; Department of Postgraduate Program in Sciences, University of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, CEP 14, Franca, SP, 404-600, Brazil., de Souza Silva T; Department of Postgraduate Program in Sciences, University of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, CEP 14, Franca, SP, 404-600, Brazil., de Freitas Pereira L; Department of Veterinary Medicine, University of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, CEP 14, Franca, SP, 404-600, Brazil., Pessinato MG; Department of Veterinary Medicine, University of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, CEP 14, Franca, SP, 404-600, Brazil., da Silva Cardoso de Brito VJ; Department of Postgraduate Program in Animal Science in the Tropics, Federal University of Bahia (UFBA), Av. Milton Santos, s/n° - Ondina, CEP, Salvador, BA, 40170-110, Brazil., Branco CH; Fábio Barreto Municipal Zoo Forest, Rua da Liberdade, s/n°, Campos Elísios, CEP, Ribeirão Preto, SP, 14085-250, Brazil., Dias FGG; Department of Postgraduate Program in Animal Science, University of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, CEP 14, Franca, SP, 404-600, Brazil. fernanda.dias@unifran.edu.br.
المصدر: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2023 Dec; Vol. 54 (4), pp. 3211-3220. Date of Electronic Publication: 2023 Aug 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Brazil NLM ID: 101095924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4405 (Electronic) Linking ISSN: 15178382 NLM ISO Abbreviation: Braz J Microbiol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2019- : Switzerland, AG : Springer International Publishing
Original Publication: Rio de Janeiro, RJ, Brasil : Sociedade Brasileira de Microbiologia
مواضيع طبية MeSH: Anti-Infective Agents, Local*/pharmacology, Guanidine ; Chlorhexidine/pharmacology ; Guanidines/pharmacology ; Microbial Sensitivity Tests
مستخلص: The aim of this study was to evaluate the antimicrobial efficacy of polyhexamethylene hydrochloride guanidine (PHMGH) compared to chlorhexidine digluconate (CLX) for use as an oral antiseptic during dental procedures in wild cats. This research is crucial due to limited information on the diversity of oral microorganisms in wild cats and the detrimental local and systemic effects of oral diseases, which highlights the importance of improving prevention and treatment strategies. Samples were collected from the oral cavities of four Puma concolor, one Panthera onca, and one Panthera leo, and the number of colony-forming units per milliliter (CFU/mL) was counted and semi-automatically identified. The antimicrobial susceptibility profile of bacterial isolates was determined using minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and time-kill kinetics of PHMGH and CLX. A total of 16 bacterial isolates were identified, consisting of six Gram-positive and 10 Gram-negative. PHMGH displayed MIC and MBC from 0.24 to 125.00 μg/mL, lower than those of CLX against three isolates. Time-kill kinetics showed that PHMGH reduced the microbial load by over 90% for all microorganisms within 30 min, whereas CLX did not. Only two Gram-positive isolates exposed to the polymer showed incomplete elimination after 60 min of contact. The results could aid in the development of effective prevention and treatment strategies for oral diseases in large felids. PHMGH showed promising potential at low concentrations and short contact times compared to the commercial product CLX, making it a possible active ingredient in oral antiseptic products for veterinary use in the future.
(© 2023. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.)
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فهرسة مساهمة: Keywords: Antiseptic; Microbiology; Synthetic polymer; System stomatognathic; Wildlife medicine
المشرفين على المادة: MOR84MUD8E (chlorhexidine gluconate)
0 (Anti-Infective Agents, Local)
JU58VJ6Y3B (Guanidine)
R4KO0DY52L (Chlorhexidine)
31961-54-3 (polyhexamethyleneguanidine)
0 (Guanidines)
تواريخ الأحداث: Date Created: 20230831 Date Completed: 20231204 Latest Revision: 20231205
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10689303
DOI: 10.1007/s42770-023-01107-x
PMID: 37651088
قاعدة البيانات: MEDLINE
الوصف
تدمد:1678-4405
DOI:10.1007/s42770-023-01107-x