دورية أكاديمية
Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization.
| العنوان: | Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization. |
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| المؤلفون: | Jang KK; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA., Heaney T; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA., London M; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA., Ding Y; Department of Laboratory Medicine, Geisinger Health, Danville, PA 17822, USA., Putzel G; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA; Antimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York, NY 10016, USA., Yeung F; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA., Ercelen D; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA., Chen YH; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA., Axelrad J; Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA., Gurunathan S; Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA., Zhou C; Cell and Molecular Biology Graduate Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Podkowik M; Antimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York, NY 10016, USA; Division of Infectious Diseases and Immunology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA., Arguelles N; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA; Antimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York, NY 10016, USA., Srivastava A; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA; Antimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York, NY 10016, USA., Shopsin B; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA; Antimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York, NY 10016, USA; Division of Infectious Diseases and Immunology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA., Torres VJ; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA; Antimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York, NY 10016, USA., Keestra-Gounder AM; Department of Immunology and Microbiology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA., Pironti A; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA; Antimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York, NY 10016, USA., Griffin ME; Department of Immunology and Microbiology, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Hang HC; Department of Immunology and Microbiology, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Cadwell K; Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: ken.cadwell@pennmedicine.upenn.edu. |
| المصدر: | Cell host & microbe [Cell Host Microbe] 2023 Sep 13; Vol. 31 (9), pp. 1450-1468.e8. Date of Electronic Publication: 2023 Aug 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, Mass. : Cell Press |
| مواضيع طبية MeSH: | Anti-Infective Agents* , Enterococcus faecium* , Inflammatory Bowel Diseases*, Animals ; Mice ; Immunity, Innate ; Lymphocytes ; Inflammation |
| مستخلص: | Loss of antimicrobial proteins such as REG3 family members compromises the integrity of the intestinal barrier. Here, we demonstrate that overproduction of REG3 proteins can also be detrimental by reducing a protective species in the microbiota. Patients with inflammatory bowel disease (IBD) experiencing flares displayed heightened levels of secreted REG3 proteins that mediated depletion of Enterococcus faecium (Efm) from the gut microbiota. Efm inoculation of mice ameliorated intestinal inflammation through activation of the innate immune receptor NOD2, which was associated with the bacterial DL-endopeptidase SagA that generates NOD2-stimulating muropeptides. NOD2 activation in myeloid cells induced interleukin-1β (IL-1β) secretion to increase the proportion of IL-22-producing CD4 + T helper cells and innate lymphoid cells that promote tissue repair. Finally, Efm was unable to protect mice carrying a NOD2 gene variant commonly found in IBD patients. Our findings demonstrate that inflammation self-perpetuates by causing aberrant antimicrobial activity that disrupts symbiotic relationships with gut microbes. Competing Interests: Declaration of interests K.C. has received research support from Pfizer, Takeda, Pacific Biosciences, Genentech, and Abbvie. K.C. has consulted for or received an honoraria from Puretech Health, Genentech, and Abbvie. K.C. is an inventor on U.S. patent 10,722,600 and provisional patent 62/935,035 and 63/157,225. H.C.H. has received research support from Rise Therapeutics and LISCure Biosciences. U.S. patents PCT/US16/28836 (H.C.H.) and PCT/US2020/019038 (H.C.H. and M.E.G.) were obtained for the commercial use of SagA-engineered bacteria. Rise Therapeutics has licensed these patents to develop SagA-probiotics as therapeutics. J.A. reports consultancy fees, honoraria, or advisory board fees from Abbvie, Adiso, Bristol Myers Squibb, Janssen, Pfizer, Fresnius, and BioFire Diagnostics. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| التعليقات: | Update of: bioRxiv. 2023 Feb 01;:. (PMID: 36778381) |
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| معلومات مُعتمدة: | F32 DK132908 United States DK NIDDK NIH HHS; P30 CA016087 United States CA NCI NIH HHS; F30 DK122698 United States DK NIDDK NIH HHS; R01 DK093668 United States DK NIDDK NIH HHS; S10 OD018338 United States OD NIH HHS; R01 AI140754 United States AI NIAID NIH HHS; R01 AI130945 United States AI NIAID NIH HHS; R01 DK124336 United States DK NIDDK NIH HHS; R01 AI121244 United States AI NIAID NIH HHS; R21 AI164154 United States AI NIAID NIH HHS; R01 AI137336 United States AI NIAID NIH HHS; R01 AI173121 United States AI NIAID NIH HHS; R01 HL123340 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: NOD2; REG3; antimicrobial proteins; enterococci; inflammatory bowel disease |
| المشرفين على المادة: | 0 (Anti-Infective Agents) |
| تواريخ الأحداث: | Date Created: 20230831 Date Completed: 20230918 Latest Revision: 20240216 |
| رمز التحديث: | 20240216 |
| مُعرف محوري في PubMed: | PMC10502928 |
| DOI: | 10.1016/j.chom.2023.08.002 |
| PMID: | 37652008 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1934-6069 |
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| DOI: | 10.1016/j.chom.2023.08.002 |